5,6-DIPHENYLPYRAZIN-2-OL

Product Name: 5,6-DIPHENYLPYRAZIN-2-OL
CAS No.: 18591-57-6
Chemical Name: 5,6-DIPHENYLPYRAZIN-2-OL
Synonyms: Selexipag Impurity 30;Selexipag Impurity 10;5,6-Diphenylpyrazinol;5,6-diphenylpyrazin-2-yl;5,6-DIPHENYLPYRAZIN-2-OL;5,6-Diphenyl-2(1H)-pyrazinone;5,6-diphenylpyrazin-2(1H)-one;5,6-diphenyl-1H-pyrazin-2-one;5,6-Diphenyl-2-hydroxypyrazine;2(1H)-Pyrazinone, 5,6-diphenyl-
CBNumber: CB9225204
Molecular Formula: C16H12N2O
Formula Weight: 248.28
MOL File: Mol file

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5,6-DIPHENYLPYRAZIN-2-OL Property

Melting point:: 225-227 °C
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 10.55±0.60(Predicted)
Appearance: Light yellow to yellow Solid
InChI: InChI=1S/C16H12N2O/c19-14-11-17-15(12-7-3-1-4-8-12)16(18-14)13-9-5-2-6-10-13/h1-11H,(H,18,19)
InChIKey: LTWBZUZTTUVPIM-UHFFFAOYSA-N
SMILES: C1(=O)NC(C2=CC=CC=C2)=C(C2=CC=CC=C2)N=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D415285
Product name: 5,6-Diphenylpyrazinol
Packaging: 25g
Price: $180
Updated: 2021/12/16

AK Scientific

Product number: 8595BA
Product name: 5,6-Diphenylpyrazin-2-ol
Packaging: 5g
Price: $107
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0046125
Product name: SELEXIPAG EP IMPURITY B
Purity: 95.00%
Packaging: 5MG
Price: $455.23
Updated: 2021/12/16

Alichem

Product number: 18591576
Product name: 5,6-Diphenylpyrazin-2-ol
Packaging: 100g
Price: $543.51
Updated: 2021/12/16

Chemenu

Product number: CM250681
Product name: 5,6-Diphenylpyrazin-2-ol
Purity: 95%+
Packaging: 25g
Price: $119
Updated: 2021/12/16

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5,6-DIPHENYLPYRAZIN-2-OL Chemical Properties,Usage,Production

Uses

5,6-Diphenylpyrazinol is a diphenylpyrazine derivative which belongs to a class of prostacyclin receptor agonists. It is impurity of Selexipag (S253150) that is a potential drug for the treatment of various vascular disorders such as pulmonary arterial hypertension and arteriosclerosis obliterans.

Synthesis

1668-10-6

134-81-6

18591-57-6

General procedure for the synthesis of 5,6-diphenyl-2-hydroxypyrazine from glycinamide hydrochloride and biphenylformamide: Biphenylformamide (62.0 g, 0.29 mol), glycinamide hydrochloride (35.37 g, 0.32 mol), and NaOH (23.2 g, 0.58 mol) were added sequentially to 500 mL of methanol, and heated at reflux under nitrogen protection for 3 to 4 hours. The reaction progress was monitored by LC-MS until the ingredients were fully reacted. The reaction solution was cooled to 0-5 °C, and 12N HCl (38 mL) was added slowly and dropwise, followed by stirring for 30 min at room temperature. To the reaction solution was added 30 g of sodium bicarbonate and 350 mL of water, followed by washing with water (20 mL) and methanol (20 mL). The solid product was collected and dried under vacuum to give 65.5 g of 5,6-diphenyl-2-hydroxypyrazine as a white solid in 91.1% yield.

References

[1] Patent: CN108623541, 2018, A. Location in patent: Paragraph 0049-0051; 0069-0072; 0089-0091; 0108-0110; 0127
[2] Patent: US2015/147840, 2015, A1. Location in patent: Page/Page column
[3] Patent: WO2017/60827, 2017, A1. Location in patent: Page/Page column 11
[4] Patent: US2015/147840, 2015, A1. Location in patent: Page/Page column
[5] Patent: US2016/108006, 2016, A1. Location in patent: Paragraph 0173-0175

5,6-DIPHENYLPYRAZIN-2-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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5,6-DIPHENYLPYRAZIN-2-OL Suppliers

China 64 India 5 The Netherlands 1 United States 3 Global 73

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Synthonix Inc

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Email: info@synthonix.com
Country: United States
ProdList: 6872
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Combi-Blocks Inc.

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Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
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View Lastest Price from 5,6-DIPHENYLPYRAZIN-2-OL manufacturers

Henan Fengda Chemical Co., Ltd

Product: 5,6-DIPHENYLPYRAZIN-2-OL 18951-57-6
Price: US $3.00-0.20/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-26

Career Henan Chemical Co

Product: 5,6-DIPHENYLPYRAZIN-2-OL 18591-57-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-13

18591-57-6, 5,6-DIPHENYLPYRAZIN-2-OLRelated Search:

Diphenylsilanediol Ethambutol Pyrazinamide Pyridine Sulfachoropyrazine sodium Pyrazine ( 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid tert-butylester ) SELEXIPAG interMediate [4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID 2,3-DIPHENYLPYRAZINE Bromoacetic acid 2-T-BUTYL GLYCOLATE 4-(Isopropylamino)butanol 5-chloro-2,3-diphenylpyrazine 2,3-Dichloro-5,6-diphenylpyrazine N-(methylsulfonyl)glycine 1-Butanol, 4-[(5,6-diphenyl-2-pyrazinyl)oxy]- Acetamide, 2-[4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-

5,6-DIPHENYLPYRAZIN-2-OL

5,6-diphenylpyrazin-2(1H)-one

5,6-Diphenylpyrazinol

5,6-Diphenyl-2(1H)-pyrazinone

5,6-Diphenyl-2-hydroxypyrazine

5,6-diphenyl-1H-pyrazin-2-one

Selexipag Impurity 10

2(1H)-Pyrazinone, 5,6-diphenyl-

Selexipag Impurity 30

5,6-diphenylpyrazin-2-yl

18591-57-6

18951-57-6