3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID
- Product Name
- 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID
- CAS No.
- 195457-70-6
- Chemical Name
- 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID
- Synonyms
- AKOS BAR-0024;RARECHEM AL BE 1367;4-[3-(trifluoromethyl)phenyl]benzoate;4-(3-(Trifluoromethyl)phenyl)benzoic acid;3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID;3'-(TRIFLUOROMETHYL)-1,1'-BIPHENYL-4-CARBOXYLIC ACID;3'-(Trifluoromethyl)[1,1'-biphenyl]-4-carboxylic acid;[1,1'-BIPHENYL]-4-CARBOXYLIC ACID, 3'-(TRIFLUOROMETHYL)-;3′-(Trifluoromethyl)-[1,1′-biphenyl]-4-carboxylic acid, CAS 195457-70-6
- CBNumber
- CB9228078
- Molecular Formula
- C14H9F3O2
- Formula Weight
- 266.22
- MOL File
- 195457-70-6.mol
3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID Property
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- color
- Yellow
- CAS DataBase Reference
- 195457-70-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T779085
- Product name
- 4-(3-Trifluoromethylphenyl)benzoicAcid
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- T779085
- Product name
- 4-(3-Trifluoromethylphenyl)benzoicAcid
- Packaging
- 1g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 014258
- Product name
- 3'-Trifluoromethyl-biphenyl-4-carboxylicacid
- Packaging
- 100mg
- Price
- $10
- Updated
- 2021/12/16
- Product number
- AMTDA072
- Product name
- 3'-Trifluromethylbiphenyl-4-carboxylicacid
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 2821-3-X2
- Product name
- 3'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid
- Packaging
- 250mg
- Price
- $40
- Updated
- 2021/12/16
3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
4-(3-Trifluoromethylphenyl)benzoic Acid is a reagent used in the synthesis of aryl-substituted aspartic acid and diaminopropionic acid derivatives as inhibitors of glutamate transporter EAAT-2 (Excitatory amino acid transporters 2).
Synthesis
586-76-5
1423-26-3
195457-70-6
The general procedure for the synthesis of 4-(3-trifluoromethylphenyl)benzoic acid from 4-bromobenzoic acid and 3-(trifluoromethyl)phenylboronic acid was as follows: Pd(dppf)Cl2 (1.49 mmol, 1.09 g) was added to a mixture containing 4-bromobenzoic acid (14.9 mmol, 3.0 g), 3-(trifluoromethyl)phenylboronic acid (17.9 mmol, 3.4 g), and Cs2CO3 (37.3 mmol, 12.2 g) in a suspension with the solvent being a mixture of 30 mL dioxane and 7.5 mL ethanol. The reaction mixture was stirred at 80 °C for 2 hours. After completion of the reaction, it was cooled to room temperature, the solid product was collected by filtration and washed with methanol. The filtrate was concentrated and the residue was partitioned between ethyl acetate and 1N aqueous hydrochloric acid. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated. To the concentrated residue was added dichloromethane, the resulting solid was collected by filtration, washed with dichloromethane and dried to give 4-(3-trifluoromethylphenyl)benzoic acid (3.58 g, 86% yield), which could be used in the next reaction without further purification.
References
[1] Patent: US2013/102584, 2013, A1. Location in patent: Paragraph 0307; 0308
[2] Journal of Medicinal Chemistry, 1997, vol. 40, # 20, p. 3144 - 3150
3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID Suppliers
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View Lastest Price from 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID manufacturers
- Product
- 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID 195457-70-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-26