7-HYDROXYFLAVONE

ChemicalBook > CAS DataBase List > 7-HYDROXYFLAVONE

Synthesis

Product Name: 7-HYDROXYFLAVONE
CAS No.: 6665-86-7
Chemical Name: 7-HYDROXYFLAVONE
Synonyms: NSC 94258;4]cycloocta[1;7-HYDROXYFLAVONE;13-tetramethoxy-6;7-dimethylbenzo[3;HYDROXYFLAVONE, 7-;7-Hydroxyflavone>TIMTEC-BB SBB005921;7-Hydroxyflavone,98%;7-Hydroxy Flavone 99%
CBNumber: CB9235797
Molecular Formula: C15H10O3
Formula Weight: 238.24
MOL File: 6665-86-7.mol

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7-HYDROXYFLAVONE Property

Melting point:: 245-247 °C (lit.)
Boiling point:: 320.83°C (rough estimate)
Density: 1.340±0.06 g/cm3 (20 ºC 760 Torr)
refractive index: 1.5740 (estimate)
Water Solubility: Insoluble in water
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: powder to crystal
pka: 7.02±0.40(Predicted)
color: White to Light yellow
BRN: 194089
LogP: 3.620
CAS DataBase Reference: 6665-86-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 41934
Product name: 7-Hydroxyflavone
Purity: analytical standard
Packaging: 50MG
Price: $113
Updated: 2024/03/01

Sigma-Aldrich

Product number: H4530
Product name: 7-Hydroxyflavone
Purity: ≥98%
Packaging: 1g
Price: $73.1
Updated: 2023/06/20

TCI Chemical

Product number: H0852
Product name: 7-Hydroxyflavone
Purity: >97.0%(T)
Packaging: 1g
Price: $63
Updated: 2024/03/01

TCI Chemical

Product number: H0852
Product name: 7-Hydroxyflavone
Purity: >97.0%(T)
Packaging: 5g
Price: $156
Updated: 2024/03/01

Alfa Aesar

Product number: A18538
Product name: 7-Hydroxyflavone, 98%
Packaging: 1g
Price: $48.65
Updated: 2024/03/01

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7-HYDROXYFLAVONE Chemical Properties,Usage,Production

Synthesis

Acetylation of resorcinol acetic acid yields 2,4-dihydroxyacetophenone, which is then subjected to benzoylation and transposition to obtain (2-hydroxy-4-benzoyloxy)benzoylacetophenone. 7-hydroxyflavone was obtained by further cyclization reaction in a mixture of acetic acid and hydrochloric acid at 103° C for 7 h.

Chemical Properties

off-white crystals

Uses

antifungal, analgesic

Uses

Reactant:

Acting as a biologically valuable acceptor in O-glycosidation reactions
Involved in synthesis of fully phosphorylated flavones for use as pancreatic cholesterol esterase inhibitors
For O-methylation with di-Me carbonate
Linked by a polymethylene chain for synthesis of α1-adrenoceptor antagonists
Involved in Baylis-Hillman reactions
Involved in phase-transfer catalyzed glucosylation for synthesis of glucosylated flavonoids

Definition

ChEBI: 7-hydroxyflavone is a hydroxyflavonoid in which the flavone nucleus is substituted at position 7 by a hydroxy group.

Synthesis Reference(s)

Tetrahedron Letters, 31, p. 6497, 1990 DOI: 10.1016/S0040-4039(00)97100-4

Biological Activity

7-Hydroxyflavone is a flavonoid isolated from M. indica with anti-inflammatory properties. It protects renal cells from nicotine (NIC)-induced cytotoxicity through the ERK/Nrf2/HO-1 pathway.

7-HYDROXYFLAVONE Preparation Products And Raw materials

Raw materials

2,4-Dihydroxyacetophenone Benzophenone

Preparation Products

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7-HYDROXYFLAVONE Suppliers

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View Lastest Price from 7-HYDROXYFLAVONE manufacturers

Shanghai Qyubiotech Co., Ltd.

Product: 7-Hydroxyflavone 6665-86-7
Price: US $0.00-0.00/g
Min. Order: 10g
Purity: 98%+
Supply Ability: 10000kgs per Month
Release date: 2023-08-17

Career Henan Chemical Co

Product: 7-HYDROXYFLAVONE 6665-86-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons
Release date: 2020-03-12

6665-86-7, 7-HYDROXYFLAVONERelated Search:

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7-Hydroxyflavone, ≥ 97.0%

6665-86-7

Building Blocks

Benzopyrans

Flavonoids

Heterocyclic Building Blocks

Mono-substituted Flavones

Biochemistry

Flavonoids