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Muramyl Dipeptide

Product Name
Muramyl Dipeptide
CAS No.
53678-77-6
Chemical Name
Muramyl Dipeptide
Synonyms
MDP;n-acetylmuramyl-l-alanyl-d-isoglutamine hydrate;HRDP;DPEP1;L-18-MDP;Aids000724;Aids-000724;Dipeptidase 1;ADJUVANT PEPTIDE;MURAMYL DIPEPTIDE
CBNumber
CB9237089
Molecular Formula
C19H32N4O11
Formula Weight
492.48
MOL File
53678-77-6.mol
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Muramyl Dipeptide Property

Boiling point:
1071.8±65.0 °C(Predicted)
alpha 
D25 +44° (acetic acid)
Density 
1.390±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
H2O: 10 mg/mL, clear, colorless
pka
4.44±0.10(Predicted)
form 
buffered aqueous solution
color 
White to off-white
Merck 
13,6329
BRN 
4220745
InChIKey
BSOQXXWZTUDTEL-HYUMGUTENA-N
SMILES
[C@H]1(O[C@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(=O)N)CCC(=O)O)[C@H](O)[C@H](OC(O)[C@@H]1NC(=O)C)CO |&1:0,2,7,12,21,23,27,r|
CAS DataBase Reference
53678-77-6(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
MA2275260
F 
10
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A9519
Product name
N-Acetylmuramyl-L-alanyl-D-isoglutamine hydrate
Purity
≥98% (TLC)
Packaging
1mg
Price
$108
Updated
2025/07/31
Sigma-Aldrich
Product number
A9519
Product name
N-Acetylmuramyl-L-alanyl-D-isoglutamine hydrate
Purity
≥98% (TLC)
Packaging
5mg
Price
$307
Updated
2025/07/31
Sigma-Aldrich
Product number
SAB1306896
Product name
ANTI-DPEP1 (N-TERM) antibody produced in rabbit
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
400μl
Price
$461
Updated
2023/01/07
Sigma-Aldrich
Product number
A9519
Product name
N-Acetylmuramyl-L-alanyl-D-isoglutamine hydrate
Purity
≥98% (TLC)
Packaging
10mg
Price
$537
Updated
2025/07/31
Sigma-Aldrich
Product number
A9519
Product name
N-Acetylmuramyl-L-alanyl-D-isoglutamine hydrate
Purity
≥98% (TLC)
Packaging
25mg
Price
$786
Updated
2025/07/31
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Muramyl Dipeptide Chemical Properties,Usage,Production

Uses

N-Acetylmuramyl-L-alanyl-D-isoglutamine hydrate has been used in staphylococcal cell wall preparation to induce the release of TNF from human monocytes.

Uses

Immunological adjuvant.

Biochem/physiol Actions

Muramyl peptides are monomeric components that make up the bacterial cell wall peptidoglycan. It is generally produced by mammalian macrophages, as an immune response in the breakdown of bacterial cell wall. MDP promotes the production of interleukin-1 and tumor necrosis factor (TNF), which increase slow-wave sleep.

in vivo

Muramyl dipeptide (1.25 mg/kg; i.p.; twice) alleviates bone loss induced by osteoporosis[1].

Animal Model:RANKL-induced osteoporosis model (Five-week-old C57BL/6 mice)[1]
Dosage:1.25 mg/kg
Administration: i.p.; twice (RANKL-induced osteoporosis for 3 weeks and euthanized at 4 weeks)
Result:Significantly enhanced the trabecular bone volume (BV/TV) and trabecular number (Tb.N).

IC 50

p38 MAPK; NLRP1

Muramyl Dipeptide Preparation Products And Raw materials

Raw materials

Preparation Products

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Muramyl Dipeptide Suppliers

China 133 France 1 Germany 2 India 1 Japan 4 Switzerland 1 United Kingdom 4 United States 18 Global 164
Hubei kangen Pharmaceutical Chemical Co., Ltd
Tel
153-15337215803 15337215803
Fax
027-89771658
Email
3357312443@qq.com
Country
China
ProdList
695
Advantage
56
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17987
Advantage
58
Shanghai Gukang Biotechnology Co., LTD
Tel
13564510648
Fax
021-54301252
Email
2985380065@qq.com
Country
China
ProdList
111
Advantage
58
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
7247
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
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58
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15873
Advantage
55
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9858
Advantage
58
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View Lastest Price from Muramyl Dipeptide manufacturers

Career Henan Chemical Co
Product
Muramyl Dipeptide 53678-77-6
Price
US $6.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg, 5kg, 50kg
Release date
2020-01-09

53678-77-6, Muramyl DipeptideRelated Search:

N-ACETYLMURAMYL-D-ALANYL-D-ISOGLUTAMINE) N-ACETYLMURAMYL-L-ALANYL-L-ISOGLUTAMINE pro-val-gly-leu-lle-gly syn-coll FREUND'S COMPLETE ADJUVANT 1-ALPHA-O-BENZYL-N-ACETYLMURAMYL-ALA-D-ISOGLN-LYS(TRANS(M-NITROCINNAMOYL)-NH2)-NH2 Romurtide Temurtide N-ACETYLMURAMYL-L-ALANYL-D-ISOGLUTAMINE-6-O-STEAROYL Muramyl Dipeptide N-ACETYL-D-GLUCOSAMINYL-Β-(1→4)-N-ACETYLMURAMYL-L-ALANYL-D-ISOGLUTAMINE N-ACETYLMURAMYL-L-ALANYL-D-ISOGLUTAMINE-6-O-STEAR GMDP AC-(6-O-STEAROYL)-MURAMYL-ALA-D-GLU-NH2

  • acetylmuramyl-alanyl-isoglutamine
  • n(sup2)-(n-(n-acetylmuramoyl)-l-alanyl)-d-alpha-glutamin
  • n(sup2)-(n-(n-acetylmuramoyl)-l-alanyl)-d-alpha-glutamine
  • Ac-muramyl-Ala-D-Glu-NH
  • N-AC-MURAMYL-ALA-D-GLU-NH2
  • N-AC-MURAMYL-ALA-D-GLU-NH2 2H2O
  • N-ACETYL-MURAMYL-L-ALA-D-ISOGLN
  • N-ACETYLMURAMYL-L-ALA-D-ISOGLUTAMINE
  • N-ACETYLMURAMYL-L-ALANYL-D-ISOGLUTAMINE
  • MURAMYL DIPEPTIDE
  • N2-[N-(N-acetylmuramoyl)-L-alanyl]-D-alpha-glutamine
  • n-acetylmuramyl-l-alanyl-d-isoglutamine hydrate
  • Adjuvant Peptide, Muramyl dipeptide
  • L-18-MDP
  • N-(N-Acetylmuramoyl)-L-Ala-D-αGlu-NH2
  • N2-[N-(N-Acetylmuramoyl)-L-alanyl]-D-isoglutamine
  • N-Acetylmuramoylalanyl-D-isoglutamine
  • Aids000724
  • Aids-000724
  • D-.alpha.-Glutamine, N-(N-acetylmuramoyl)-L-alanyl-
  • Ac-MuraMyl-Ala-D-Isogln-OH, MDP, MuraMyl Dipeptide
  • Dipeptidase 1 (renal)
  • HRDP
  • ANTI-DPEP1 (N-TERM) antibody produced in rabbit
  • Dehydropeptidase-I
  • Dipeptidase 1
  • DPEP1
  • N-ACETYLMURAMYLL-ALANYL-D-ISOGLUTAMI
  • (4R)-4-{[(2S)-2-{[(2R)-2-{[(3R,4R,5S,6R)-3-Acetamido-2,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoyl]amino}propanoyl]amino}-5-amino-5-oxopentanoic acid
  • AC-MURAMYL-ALA-D-GLN
  • AC-MURAMYL-ALA-D-GLU-NH2
  • AC-MURAMYL-ALA-D-ISOGLN-OH
  • AC-MURAMYL-ALA-D-ISOGLUTAMINE
  • ADJUVANT PEPTIDE
  • N-Acetylmuramyl-L-alanyl-D-isoglnamine hydrate
  • MDP
  • N-Acetylmuramoyl-L-alanyl-D-α-glutamine
  • Muramyl dipeptide (MDP)
  • D-α-Glutamine, N-(N-acetylmuramoyl)-L-alanyl-
  • N-Acetylmuramyl-L-alanyl-D-isoglutamine hydrate >=98% (TLC)
  • Recombinant Human DPEP1 Protein, His Tag
  • Muramoyl dipeptide
  • Muramyl Dipeptide USP/EP/BP
  • Ac-muramyl-Ala-D-Glu-NH2 (G-1055.0005)
  • D-a-Glutamine,N-(N-acetylmuramoyl)-L-alanyl-
  • (4R,5R,7R,10S,13R)-13-Carbamoyl-4-formyl-7,10-dimethyl-2,8,11-trioxo-5-((1R,2R)-1,2,3-trihydroxypropyl)-6-oxa-3,9,12-triazahexadecan-16-oic acid
  • (4R,5R,7R,10S,13R)-13-Carbamoyl-4-formyl-7,10-dimethyl-2,8,11-trioxo-5-((1R,2R)-1,2,3-trihydroxypropyl)-6-oxa-3,9,12-triazahexadecan-16-oic acid , Muramyl dipeptide
  • Muramyl dipeptide, 10 mM in DMSO
  • N-Acetylmuramyl-<sc>L</sc>-alanyl-<sc>D</sc>-isoglutamine hydrate
  • N2-[N-(N-acetylmuramoyl)-L-alanyl]-D-α-glutamine
  • 53678-77-6
  • C19H32N4O11
  • C19H32N4O11xH2O
  • Biochemicals and Reagents
  • Dipeptides and Tripeptides
  • Peptides
  • Other Peptides
  • Amino Acids and Peptides