4-(Trimethylsilyl)-3-butyn-2-one
- Product Name
- 4-(Trimethylsilyl)-3-butyn-2-one
- CAS No.
- 5930-98-3
- Chemical Name
- 4-(Trimethylsilyl)-3-butyn-2-one
- Synonyms
- DKSI102;DKFELEX0334;TIMTEC-BB SBB009031;4-TRIMETHYLSILYL-3-BUTYN-2-ONE;4-trimethylsilylbut-3-yn-2-one;4-(Trimethysilyl)-3-butyn-2-one;4-TriMethylsilanyl-but-3-yn-2-one;4-(trimehtylsilyl)-3-Butyne-2-one;3-Butyn-2-one, 4-(trimethylsilyl)-;4-(TRIMETHYLSILYL)-3-BUTYN-2-ONE 98%
- CBNumber
- CB9242865
- Molecular Formula
- C7H12OSi
- Formula Weight
- 140.26
- MOL File
- 5930-98-3.mol
4-(Trimethylsilyl)-3-butyn-2-one Property
- Melting point:
- 99 °C
- Boiling point:
- 156 °C(lit.)
- Density
- 0.854 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.442(lit.)
- Flash point:
- 83 °F
- storage temp.
- Flammables area
- form
- clear liquid
- color
- Colorless to Light yellow to Light orange
- Specific Gravity
- 0.854
- Hydrolytic Sensitivity
- 4: no reaction with water under neutral conditions
- InChI
- InChI=1S/C7H12OSi/c1-7(8)5-6-9(2,3)4/h1-4H3
- InChIKey
- NQEZDDPEJMKMOS-UHFFFAOYSA-N
- SMILES
- CC(=O)C#C[Si](C)(C)C
- CAS DataBase Reference
- 5930-98-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 10-36/37/38
- Safety Statements
- 16-26-36-37/39
- RIDADR
- UN 1224 3/PG 3
- WGK Germany
- 3
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29319090
- Storage Class
- 3 - Flammable liquids
- Hazard Classifications
- Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 418676
- Product name
- 4-(Trimethylsilyl)-3-butyn-2-one
- Purity
- 97%
- Packaging
- 5g
- Price
- $101
- Updated
- 2026/03/19
- Product number
- T2973
- Product name
- 4-(Trimethylsilyl)-3-butyn-2-one
- Purity
- >97.0%(GC)
- Packaging
- 5mL
- Price
- $72
- Updated
- 2026/03/19
- Product number
- T2973
- Product name
- 4-(Trimethylsilyl)-3-butyn-2-one
- Purity
- >97.0%(GC)
- Packaging
- 25mL
- Price
- $247
- Updated
- 2026/03/19
- Product number
- T896175
- Product name
- 4-(Trimethylsilyl)-3-butyn-2-one
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 83381
- Product name
- 4-TMS-3-BUTYN-2-ONE
- Packaging
- 10g
- Price
- $166.22
- Updated
- 2021/12/16
4-(Trimethylsilyl)-3-butyn-2-one Chemical Properties,Usage,Production
Chemical Properties
clear slightly yellow liquid
Uses
4-(Trimethylsilyl)-3-butyn-2-one (TMSB) has been used to investigate its asymmetric bioreduction to (S)-4-(trimethylsilyl)-3-butyn-2-ol {(S)-TMSBOL} by employing biocompatible water-immiscible ionic liquids (ILs). TMSB may be used for the synthesis of entecavir (BMS-200475).
General Description
4-(Trimethylsilyl)-3-butyn-2-one is a ketone. Its asymmetric bioreduction to enantiopure {(S)-TMSBOL in various hydrophilic ionic liquid (ILs) solvent systems has been reported.
Synthesis
Equipped with a thermometer, spherical condenser tube (the upper end of the connection of anhydrous calcium chloride drying tube and then pass into the NaOH aqueous solution) in a 100 ml three-necked bottle, according to a certain charging method, in accordance with a certain proportion of bis (trimethylsilyl) acetylene and methanol added to the reaction bottle, and constantly pass into the nitrogen to open the reaction, when the temperature rises to 60 ~ 80 , began to add acetyl chloride droplets, reaction of the resulting HCI from the continuous passage of nitrogen brought out by the condensation tube, in the drying tube by NaOH aqueous solution absorption, titration is complete, and then continue to reflux for a certain period of time until the reaction temperature is no longer elevated, stop the reaction, the reaction device was quickly converted to a decompression distillation extracted half an hour of the gas for the exclusion of residual trace HCI gas, and then converted to atmospheric distillation of the reaction device to collect the fractions of 185 or so, that is, the final The target product 4-trimethylsilyl-3-butyn-2-one (content higher than 97%).
4-(Trimethylsilyl)-3-butyn-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(Trimethylsilyl)-3-butyn-2-one manufacturers
- Product
- 4-(Trimethylsilyl)-3-butyn-2-one 5930-98-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 97.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-07-08
- Product
- 4-(Trimethylsilyl)-3-butyn-2-one 5930-98-3
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-27
- Product
- 4-(Trimethylsilyl)-3-butyn-2-one 5930-98-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10