ChemicalBook > CAS DataBase List > N-(2-Hydroxyethyl)adenosine

N-(2-Hydroxyethyl)adenosine

Product Name
N-(2-Hydroxyethyl)adenosine
CAS No.
4338-48-1
Chemical Name
N-(2-Hydroxyethyl)adenosine
Synonyms
NSC 54251;6-Hydroxyethyladenosine;N-(2-Hydroxyethyl)adenosine;N6-(2-Hydroxyethyl)adenosine;Adenosine, N-(2-hydroxyethyl)-;N6-(2-Hydroxyethyl)adenosine, 10 mM in DMSO;(2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)amino)-9H-purin-9-yl);(2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4;(2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-di;(2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)aMino)-9H-purin-9-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol
CBNumber
CB92431540
Molecular Formula
C12H17N5O5
Formula Weight
311.29
MOL File
4338-48-1.mol
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N-(2-Hydroxyethyl)adenosine Property

Melting point:
194-195℃
Boiling point:
725.8±70.0 °C(Predicted)
Density 
1.88
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
13.11±0.70(Predicted)
color 
White to Off-White
InChI
InChI=1S/C12H17N5O5/c18-2-1-13-10-7-11(15-4-14-10)17(5-16-7)12-9(21)8(20)6(3-19)22-12/h4-6,8-9,12,18-21H,1-3H2,(H,13,14,15)/t6-,8-,9-,12-/m1/s1
InChIKey
BBOCDRLDMQHWJP-WOUKDFQISA-N
SMILES
OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)NCCO)N=C2)[C@H](O)[C@@H]1O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
H998120
Product name
N-(2-Hydroxyethyl)adenosine
Packaging
25mg
Price
$95
Updated
2021/12/16
TRC
Product number
H998120
Product name
N-(2-Hydroxyethyl)adenosine
Packaging
250mg
Price
$305
Updated
2021/12/16
TRC
Product number
H998120
Product name
N-(2-Hydroxyethyl)adenosine
Packaging
1g
Price
$880
Updated
2021/12/16
Matrix Scientific
Product number
096144
Product name
(2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Purity
95+%
Packaging
1g
Price
$1647
Updated
2021/12/16
AK Scientific
Product number
5992AB
Product name
(2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Packaging
1g
Price
$2273
Updated
2021/12/16
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N-(2-Hydroxyethyl)adenosine Chemical Properties,Usage,Production

Uses

N-(2-Hydroxyethyl)adenosine has been studied as an anticonvulsant through the activation of adenosine A1 receptor (AA1R).

in vivo

N6-(2-Hydroxyethyl)adenosine (20-40 mg/kg, ip, once daily for 6 weeks) reduces the blood glucose level and diabetes-induced kidney damage, increases the activities of antioxidant enzymes (such as SOD, catalase CAT and GSH) in renal tissue, reduces the level of malondialdehyde (MDA), exhibits anti-inflammatory and antioxidant activities, and ameliorates Alloxan (HY-W017227)-induced diabetes in rats models[2].
N6-(2-Hydroxyethyl)adenosine (75-150 mg/kg, po, once daily for 19 days) exhibits antitumor effect in SGC-7901 xenograft mouse models[4].

Animal Model:Alloxan-induced diabetes in rats models[2]
Dosage:20-40 mg/kg
Administration:ip, once daily for 6 weeks
Result:Reduced the levels of blood glucose, serum creatinine (Scr), blood urea nitrogen (BUN) and urine protein.
Reduced the levels of TNF-α, IL-1β, IL-6, TGF-β1 and NF-κB in kidney tissue.
Alleviated the damage of glomeruli and renal tubules.
Animal Model:SGC-7901 xenograft mouse models[4]
Dosage:75-150 mg/kg
Administration:po, once daily for 19 days
Result:Reduced tumor volume and weight.

N-(2-Hydroxyethyl)adenosine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-(2-Hydroxyethyl)adenosine manufacturers

Shenzhen Nexcon Pharmatechs Ltd.
Product
N-(2-Hydroxyethyl)adenosine 4338-48-1
Price
US $0.00-0.00/G
Min. Order
1G
Purity
97%
Supply Ability
2000
Release date
2025-06-04
Henan Aochuang Chemical Co.,Ltd.
Product
N-(2-Hydroxyethyl)adenosine 4338-48-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26
Career Henan Chemical Co
Product
N-(2-Hydroxyethyl)adenosine 4338-48-1
Price
US $5.00/KG
Min. Order
5KG
Purity
99%
Supply Ability
1ton
Release date
2019-08-02

4338-48-1, N-(2-Hydroxyethyl)adenosineRelated Search:

ADP Hydroxyethyl urea

  • NSC 54251
  • (2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-di
  • N-(2-Hydroxyethyl)adenosine
  • 6-Hydroxyethyladenosine
  • N6-(2-Hydroxyethyl)adenosine
  • (2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)aMino)-9H-purin-9-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4
  • Adenosine, N-(2-hydroxyethyl)-
  • N6-(2-Hydroxyethyl)adenosine, 10 mM in DMSO
  • (2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)amino)-9H-purin-9-yl)
  • 4338-48-1