ChemicalBook > CAS DataBase List > LINDERANE

LINDERANE

Product Name: LINDERANE
CAS No.: 13476-25-0
Chemical Name: LINDERANE
Synonyms: linerane;LINDERANE;Linderane-RM;LINDERANE(RG);wuyaomineizhi;Linderane ,98%;Linderane, 98%, from Lindera aggregata (Sims) Kosterm.;(1aS,4E,10S,10aS)-3,6,10,10a-Tetrahydro-5,9-dimethyl-2H-10,1a-(epoxymethano)oxireno[4,5]cyclodeca[1,2-b]furan-12-one;(1aS,4E,10S,10aS)-3,6,10,10a-Tetrahydro-5,9-dimethyl-10,1a-(epoxymethano)-2H-oxireno[4,5]cyclodeca[1,2-b]furan-12-one;2H-10,1a-(Epoxymethano)oxireno[4,5]cyclodeca[1,2-b]furan-12-one,3,6,10,10a-tetrahydro-5,9-dimethyl-, (1aS,4E,10S,10aS)-
CBNumber: CB9243408
Molecular Formula: C15H16O4
Formula Weight: 260.29
MOL File: 13476-25-0.mol

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LINDERANE Property

Melting point:: 190～191℃
Boiling point:: 434.5±45.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
Stability:: Hygroscopic

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Safety

Safety Statements: 24/25
HS Code: 29322090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL80489
Product name: Linderane
Purity: phyproof? Reference Substance
Packaging: 10mg
Price: $499
Updated: 2025/07/31

Cayman Chemical

Product number: 27479
Product name: Linderane
Packaging: 5mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 27479
Product name: Linderane
Packaging: 10mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 27479
Product name: Linderane
Packaging: 25mg
Price: $151
Updated: 2024/03/01

Cayman Chemical

Product number: 27479
Product name: Linderane
Packaging: 50mg
Price: $278
Updated: 2024/03/01

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LINDERANE Chemical Properties,Usage,Production

Description

Linderane is a sesquiterpene that has been found in L. aggregata. It inhibits the cytochrome P450 (CYP) isoform CYP2C9 (K_i = 1.26 μM) in an irreversible and NADPH-dependent manner. Linderane decreases phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) gene expression, cAMP concentration, and CREB phosphorylation, increases phosphodiesterase 3 (PDE3) activity, and inhibits gluconeogenesis in rat primary hepatocytes. In vivo, linderane (50 mg/kg twice per day) decreases serum and hepatic triglyceride levels, as well as random-fed and fasting blood glucose levels in ob/ob mice.

Chemical Properties

It is derived from Lindera aggregata (Sims) Kosterm, a plant of the genus Lindera in the Lauraceae family.

Uses

Linderane is a sequiterpene lactone extract from Lindera strychnifolia compound used as a cytotoxic agent against hepaic stellate cells.

Definition

ChEBI: Linderane is a member of dioxanes.

IC 50

CYP2

References

[1] HUI WANG. Mechanism-based inactivation of CYP2C9 by linderane.[J]. Xenobiotica, 2015, 45 12: 1037-1046. DOI: 10.3109/00498254.2015.1041002
[2] WEI XIE. Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3.[J]. Frontiers in Pharmacology, 2018: 476. DOI: 10.3389/fphar.2018.00476

LINDERANE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from LINDERANE manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Linderane 13476-25-0
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-22

Shanghai Standard Technology Co., Ltd.

Product: Linderane 13476-25-0
Price: US $0.00/mg
Min. Order: 5mg
Purity: Analytical Standard
Supply Ability: 10 g
Release date: 2019-10-22

Career Henan Chemical Co

Product: LINDERANE 13476-25-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-05-25

13476-25-0, LINDERANERelated Search:

Vindoline SCHIZANDRIN B Evodiamine Schisantherin A IMPERIALINE Schisandrin WUWEIZISU C Crocin 1-[(2E,4E,6E,8E,10E,12E,14E)-b-D-glucopyranosyl 2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate] 6-O-b-D-glucopyranosyl-b-D-Glucopyranose 2α,19α－Dihydroxyursolic acid 6-(2-O-alpha-L-Arabinopyranosyl-beta-D-glucopyranosyl)-2-[4-(beta-D-glucopyranosyloxy)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one Rutaecarpine schisanhenol LAUROLITSINE HEXABROMOBENZENE 1,4-Dioxan-2-one LINDERANE 3,4-Epoxytetrahydrofuran

LINDERANE

2H-10,1a-(Epoxymethano)oxireno[4,5]cyclodeca[1,2-b]furan-12-one,3,6,10,10a-tetrahydro-5,9-dimethyl-, (1aS,4E,10S,10aS)-

(1aS,4E,10S,10aS)-3,6,10,10a-Tetrahydro-5,9-dimethyl-10,1a-(epoxymethano)-2H-oxireno[4,5]cyclodeca[1,2-b]furan-12-one

(1aS,4E,10S,10aS)-3,6,10,10a-Tetrahydro-5,9-dimethyl-2H-10,1a-(epoxymethano)oxireno[4,5]cyclodeca[1,2-b]furan-12-one

LINDERANE(RG)

Linderane ,98%

Linderane, 98%, from Lindera aggregata (Sims) Kosterm.

wuyaomineizhi

linerane

Linderane-RM

13476-25-0

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract