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2-Chloro-N-phenyl-isonicotinamide

Product Name
2-Chloro-N-phenyl-isonicotinamide
CAS No.
80194-83-8
Chemical Name
2-Chloro-N-phenyl-isonicotinamide
Synonyms
2-chloroisonicotinanilide;2-Chloro-N-phenyl-isonicotimide;2-Chloro-N-phenyl-isonicotinamide;4-Pyridinecarboxamide, 2-chloro-N-phenyl-
CBNumber
CB92445682
Molecular Formula
C12H9ClN2O
Formula Weight
232.67
MOL File
80194-83-8.mol
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2-Chloro-N-phenyl-isonicotinamide Property

Boiling point:
310.5±27.0 °C(Predicted)
Density 
1.341±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
11.19±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
2510AC
Product name
2-Chloro-N-phenylisonicotinamide
Packaging
250mg
Price
$92
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0069800
Product name
2-CHLORO-N-PHENYLPYRIDINE-4-CARBOXAMIDE
Purity
95.00%
Packaging
1G
Price
$765.23
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0069800
Product name
2-CHLORO-N-PHENYLPYRIDINE-4-CARBOXAMIDE
Purity
95.00%
Packaging
2.5G
Price
$1065.66
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0069800
Product name
2-CHLORO-N-PHENYLPYRIDINE-4-CARBOXAMIDE
Purity
95.00%
Packaging
5G
Price
$1295.03
Updated
2021/12/16
Ambeed
Product number
A121197
Product name
2-Chloro-N-phenylisonicotinamide
Purity
97%
Packaging
250mg
Price
$11
Updated
2021/12/16
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2-Chloro-N-phenyl-isonicotinamide Chemical Properties,Usage,Production

Synthesis

65287-34-5

62-53-3

80194-83-8

General procedure for the synthesis of 2-chloro-N-phenylisonicotinamide: 2-chloroisonicotinoyl chloride (10 g, 56.8 mmol) was dissolved in 1,2-dichloroethane (100 mL) and cooled to 0 °C. A mixed solution of aniline (5.70 mL, 62.5 mmol) and N,N-diisopropylethylamine (DIPEA, 10.2 mL, 59.6 mmol) in 1,2-dichloroethane (10 mL) was added slowly over about 1 hour. The reaction mixture was stirred at 0 °C for 1 h, then warmed up to 95 °C and kept for 1 h. The reaction was carried out at 0 °C. Upon completion of the reaction, it was cooled to room temperature, the reaction was quenched by the addition of water (30 mL) and the mixture was filtered. The filtrate was extracted with dichloromethane (200 mL) and the organic phases were combined. The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was recrystallized with methanol/water (1:10, 110 mL) to afford the target product 2-chloro-N-phenylisonicotinamide (12.12 g, 92% yield).LC-MS analysis: retention time (RT) = 0.87 min; electrospray ionization mass spectrometry (ES+) = 233.1.

References

[1] Patent: WO2005/40120, 2005, A1. Location in patent: Page/Page column 23
[2] Patent: WO2005/40165, 2005, A1. Location in patent: Page/Page column 22
[3] Patent: WO2005/40173, 2005, A1. Location in patent: Page/Page column 33-34
[4] Patent: WO2005/54243, 2005, A1. Location in patent: Page/Page column 24-25
[5] Patent: WO2005/54244, 2005, A2. Location in patent: Page/Page column 23

2-Chloro-N-phenyl-isonicotinamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-N-phenyl-isonicotinamide Suppliers

China 40 Germany 1 India 1 Switzerland 1 United States 4 Global 47
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
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China
ProdList
2809
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Chiba Pharmaceutical Science and technology Co, Ltd.
Tel
0531-81313138 13066006660
Fax
QQ: 3366077777
Email
chibapharm@foxmail.com
Country
China
ProdList
3992
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Tianjin Englon Technology Co., LTD
Tel
010-010-1234567 17526513758
Email
2062435649@qq.com
Country
China
ProdList
97
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Synchem OHG
Tel
+49 5662 408730
Fax
+49 5662 4087320
Email
info@synchem.de
Country
Germany
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Accela ChemBio Inc.
Tel
+1(858) 699-3322
Fax
+1(858) 876-1948
Email
marketing@accelachem.com
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United States
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6024
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Shanghai Uchem Inc.
Tel
15618758386; 15618758386
Fax
QQ:3004479444
Email
sales3@myuchem.com
Country
China
ProdList
1999
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55
Zhengzhou kangnuochenrui Chemical Technology Co.,Ltd
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18210788515
Fax
18210788515
Email
zhuzixin999@163.c0m
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China
ProdList
2998
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55
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
3495
Advantage
58
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
028-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
7218
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58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
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View Lastest Price from 2-Chloro-N-phenyl-isonicotinamide manufacturers

Career Henan Chemica Co
Product
2-Chloro-N-phenyl-isonicotinamide 80194-83-8
Price
US $1.00/g
Min. Order
1g
Purity
85.0-99.8%
Supply Ability
20ton
Release date
2020-10-28

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