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2-(Trifluoromethyl)pyridin-4-ol

Product Name
2-(Trifluoromethyl)pyridin-4-ol
CAS No.
170886-13-2
Chemical Name
2-(Trifluoromethyl)pyridin-4-ol
Synonyms
BUTTPARK 182\50-50;4-Hydroxy-2-(trifL;2-(TRIFLUOROMETHYL)PYRIDIN-4-OL;2-(trifluoromethyl)-4-Pyridinol;4-Pyridinol, 2-(trifluoromethyl)-;4-hydro-2-(trifluoromethyl)pyridine;2-(trifluoromethyl)-1H-pyridin-4-one;2-(Trifluoromethyl)pyridin-4-ol, 4-H;2-(TrifluoroMethyl)pyridin-4(1H)-one;4-Hydroxy-2-(trifluoromethyl)pyridine
CBNumber
CB92446689
Molecular Formula
C6H4F3NO
Formula Weight
163.1
MOL File
170886-13-2.mol
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2-(Trifluoromethyl)pyridin-4-ol Property

Melting point:
120.0 to 124.0 °C
Boiling point:
324.4±37.0 °C(Predicted)
Density 
1.423
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
7.53±0.10(Predicted)
form 
Powder
color 
Off-white
InChI
InChI=1S/C6H4F3NO/c7-6(8,9)5-3-4(11)1-2-10-5/h1-3H,(H,10,11)
InChIKey
LKHCWMQMRXAPHX-UHFFFAOYSA-N
SMILES
C1(C(F)(F)F)=NC=CC(O)=C1
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
H1528
Product name
4-Hydroxy-2-(trifluoromethyl)pyridine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$102
Updated
2025/07/31
TCI Chemical
Product number
H1528
Product name
4-Hydroxy-2-(trifluoromethyl)pyridine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$469
Updated
2025/07/31
TRC
Product number
T895733
Product name
2-(Trifluoromethyl)pyridin-4-ol
Packaging
500mg
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
076827
Product name
4-Hydroxy-2-(trifluoromethyl)pyridine
Purity
98%
Packaging
5g
Price
$94
Updated
2021/12/16
AK Scientific
Product number
J99653
Product name
2-(Trifluoromethyl)pyridin-4-ol
Packaging
5g
Price
$95
Updated
2021/12/16
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2-(Trifluoromethyl)pyridin-4-ol Chemical Properties,Usage,Production

Uses

2-(Trifluoromethyl)pyridin-4-ol is a pyridine derivative. Its molecular structure contains trifluoromethyl and hydroxyl reactive groups, which have high reactivity and are prone to substitution reactions, and can be used to prepare 4-Chloro-2-(trifluoromethyl)pyridine, 2-(trifluoromethyl)isonicotinic acid and 4-Amino-2-( trifluoromethyl)pyridine.

Synthesis

1297137-35-9

1297137-78-0

170886-13-2

Step F4: Under dry conditions, 3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-2-carboxylic acid (0.092 g, 0.302 mmol) and 1-(3-methylcyclopentyl)-2-piperazinone (0.060 g, 0.274 mmol) were dissolved in DMF (3.07 mL). Subsequently, HATU (0.115 g, 0.302 mmol) and DIPEA (0.120 mL, 0.686 mmol) were added. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the reaction mixture was diluted with EtOAc and water. The organic phase was separated and washed sequentially with 5% LiCl aqueous solution (3 times), saturated NaHCO3 aqueous solution (3/4 v/v), brine, then dried with anhydrous MgSO4, filtered and concentrated. The crude product was purified by silica gel column chromatography (elution gradient: 0-2% MeOH/DCM) to afford the title compound (0.101 g, 79% yield) as a white solid.1H NMR (400 MHz, chloroform-d) δ ppm: 7.37-7.48 (m, 1H), 7.06 (br.s., 1H), 4.87-5.21 (m, 1H) , 4.42-4.51 (m, 1H), 4.34 (s, 1H), 3.90-4.12 (m, 2H), 3.43 (d, J = 5.66 Hz, 2H), 1.79-2.19 (m, 5H), 1.46-1.56 (m, 1H), 1.10-1.32 (m, 4H), 1.04 (ddd, J = 12.58, 6.44, 2.24 H 6.44, 2.24 Hz, 3H), 0.87 (d, J = 5.27 Hz, 2H). ES-LCMS m/z: 469.3 (M + 1).

References

[1] Patent: WO2011/50284, 2011, A1. Location in patent: Page/Page column 127

2-(Trifluoromethyl)pyridin-4-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(Trifluoromethyl)pyridin-4-ol Suppliers

Americas 1 China 182 Europe 1 Germany 1 India 2 Japan 1 United Kingdom 1 United States 11 Global 200
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
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View Lastest Price from 2-(Trifluoromethyl)pyridin-4-ol manufacturers

Henan Fengda Chemical Co., Ltd
Product
2-(Trifluoromethyl)-4-pyridinol 170886-13-2
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-30
Dideu Industries Group Limited
Product
2-(TRIFLUOROMETHYL)-4-HYDROXYPYRIDINE 170886-13-2
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-09-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-(TRIFLUOROMETHYL)-4-HYDROXYPYRIDINE 170886-13-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

170886-13-2, 2-(Trifluoromethyl)pyridin-4-olRelated Search:

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  • 2-(TRIFLUOROMETHYL)-4-HYDROXYPYRIDINE
  • 2-(TRIFLUOROMETHYL)PYRIDIN-4-OL
  • BUTTPARK 182\50-50
  • 4-Hydroxy-2-(trifluoromethyl)pyridine
  • 2-(TrifluoroMethyl)pyridin-4(1H)-one
  • 2-(Trifluoromethyl)pyridin-4-ol, 4-H
  • 2-(Trifluoromethyl)pyridin-4-ol, 4-Hydroxy-alpha,alpha,alpha-trifluoro-2-picoline
  • 2-(trifluoromethyl)-4-Pyridinol
  • 2-(trifluoromethyl)-1,4-dihydropyridin-4-one
  • 4-hydro-2-(trifluoromethyl)pyridine
  • 2-(trifluoromethyl)-1H-pyridin-4-one
  • 4-Hydroxy-2-(trifluoromethyl)pyridine&gt
  • 4-Hydroxy-2-(trifL
  • 4-Pyridinol, 2-(trifluoromethyl)-
  • 4-Hydroxy-2-(trifluoromethyl)pyridine,97%
  • 2-(TRIFLUOROMETHYL)-4-HYDROXYPYRIDINE ISO 9001：2015 REACH
  • 170886-13-2