SIRT1 ACTIVATOR 3
- Product Name
- SIRT1 ACTIVATOR 3
- CAS No.
- 839699-72-8
- Chemical Name
- SIRT1 ACTIVATOR 3
- Synonyms
- CAY10591;SIRT1 ACTIVATOR 3;CAY10591 Exclusive;SIRTUIN 1 ACTIVATOR 3;1H-Pyrrolo[2,3-b]quinoxaline-3-carboxamide, 2-amino-N-cyclopentyl-1-(3-methoxypropyl)-
- CBNumber
- CB92448234
- Molecular Formula
- C20H25N5O2
- Formula Weight
- 367.44
- MOL File
- 839699-72-8.mol
SIRT1 ACTIVATOR 3 Property
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml).
- form
- solid
- color
- Olive green
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
N-Bromosuccinimide Price
- Product number
- 10009797
- Product name
- CAY10591
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2026/04/30
- Product number
- 10009797
- Product name
- CAY10591
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $88
- Updated
- 2026/04/30
- Product number
- 10009797
- Product name
- CAY10591
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $160
- Updated
- 2026/04/30
- Product number
- 10009797
- Product name
- CAY10591
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $359
- Updated
- 2026/04/30
- Product number
- 10009797
- Product name
- CAY10591
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $64
- Updated
- 2024/03/01
SIRT1 ACTIVATOR 3 Chemical Properties,Usage,Production
Description
SirtAct (839699-72-8) is a Sirt1 activator (233% at 10 μM)1 Suppresses TNFα release from THP-1 cells and stimulates adipogenesis in 3T3L1 cells.1 SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in mice.2 SirtAct inhibits NFκB activation and reduces inflammatory cytokine production in lamina propria mononuclear cells from IBD patients.3 Prevents and cures experimental colitis in a mouse model.3
Uses
SIRT1 Activator 3 is a SIRT1 activator which also inhibits TNF-α.
Definition
ChEBI: CAY10591 is a quinoxaline derivative.
References
[1] VASANTHA M. NAYAGAM . SIRT1 Modulating Compounds from High-Throughput Screening as Anti-Inflammatory and Insulin-Sensitizing Agents[J]. SLAS Discovery, 2006, 11 8: Pages 959-967. DOI:10.1177/1087057106294710
[2] SILVIA S BARBIERI. Cyclooxygenase-2-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor in a sirtuin-1-dependent-manner.[J]. Circulation, 2012, 126 11: 1373-1384. DOI:10.1161/circulationaha.112.097295
[3] R CARUSO. Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut[J]. Mucosal Immunology, 2014, 7 6: 1467-1479. DOI:10.1038/mi.2014.35
SIRT1 ACTIVATOR 3 Preparation Products And Raw materials
Raw materials
Preparation Products
SIRT1 ACTIVATOR 3 Suppliers
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