5-Bromo-2,4-difluorobenzaldehyde
- Product Name
- 5-Bromo-2,4-difluorobenzaldehyde
- CAS No.
- 473416-91-0
- Chemical Name
- 5-Bromo-2,4-difluorobenzaldehyde
- Synonyms
- 5-BroMo-2,4-difluorobenzaldehyde;BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO
- CBNumber
- CB92451672
- Molecular Formula
- C7H3BrF2O
- Formula Weight
- 221
- MOL File
- 473416-91-0.mol
5-Bromo-2,4-difluorobenzaldehyde Property
- Boiling point:
- 229.4±35.0 °C(Predicted)
- Density
- 1.758±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- fused solid
- color
- Faint lemon
Safety
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B677795
- Product name
- 5-Bromo-2,4-difluorobenzaldehyde
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- PC52118
- Product name
- 5-Bromo-2,4-difluorobenzaldehyde
- Packaging
- 1g
- Price
- $19
- Updated
- 2021/12/16
- Product number
- 2615-B-28
- Product name
- 5-Bromo-2,4-difluorobenzaldehyde
- Packaging
- 1g
- Price
- $21
- Updated
- 2021/12/16
- Product number
- PC52118
- Product name
- 5-Bromo-2,4-difluorobenzaldehyde
- Packaging
- 5g
- Price
- $57
- Updated
- 2021/12/16
- Product number
- 2615-B-28
- Product name
- 5-Bromo-2,4-difluorobenzaldehyde
- Packaging
- 5G
- Price
- $63
- Updated
- 2021/12/16
5-Bromo-2,4-difluorobenzaldehyde Chemical Properties,Usage,Production
Uses
5-Bromo-2,4-difluorobenzaldehyde is a fluorobenzaldehyde analogue, commonly used as a pharmaceutical intermediate.
Synthesis
28342-75-8
68-12-2
473416-91-0
General procedure for the synthesis of 5-bromo-2,4-difluorobenzaldehyde from 1,5-dibromo-2,4-difluorobenzene and N,N-dimethylformamide: 1,5-dibromo-2,4-difluorobenzene (17.5 g, 64.2 mmol) was dissolved in ether (100 mL) at -78 °C, and n-butyllithium (2.5 M, 30.8 mL, 77 mmol) was added slowly (2.5 M, 30.8 mL, 77 mmol), over a period of 5 minutes. The reaction mixture was continued to be stirred at -78 °C for 30 min. Subsequently, N,N-dimethylformamide (9.94 mL, 148 mmol) was added all at once and the mixture was stirred at the same temperature for another 30 minutes. After completion of the reaction, the reaction mixture was treated with ethyl acetate and saturated sodium bicarbonate solution. The crude product was purified by silica gel column chromatography using 0-10% ethyl acetate/hexane as eluent to afford the target compound 5-bromo-2,4-difluorobenzaldehyde as a light yellow oil (8.5 g, 60% yield). The product was characterized by 1H NMR (400 MHz, chloroform-d): δ10.26 (s, 1H), 8.14 (t, J=7.5 Hz, 1H), 7.05 (dd, J=9.8,8.0 Hz, 1H).
References
[1] Patent: US2011/9395, 2011, A1. Location in patent: Page/Page column 22
[2] Patent: WO2012/162334, 2012, A1. Location in patent: Page/Page column 38-39
[3] Patent: WO2014/98831, 2014, A1. Location in patent: Page/Page column 27
5-Bromo-2,4-difluorobenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
5-Bromo-2,4-difluorobenzaldehyde Suppliers
- Tel
- --
- Fax
- --
- sales@apolloscientific.co.uk
- Country
- United Kingdom
- ProdList
- 6084
- Advantage
- 88
View Lastest Price from 5-Bromo-2,4-difluorobenzaldehyde manufacturers
- Product
- BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO 473416-91-0
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-17