ChemicalBook > CAS DataBase List > 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE

Product Name
2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
CAS No.
265312-55-8
Chemical Name
2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
Synonyms
RYUVIDINE;Cdk4 Inhibitor III;2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione;2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE;2-methyl-5-[(4-methylphenyl)amino]benzothiazole-4,7-dione;4,7-Benzothiazoledione, 2-methyl-5-[(4-methylphenyl)amino]-
CBNumber
CB92453429
Molecular Formula
C15H12N2O2S
Formula Weight
284.33
MOL File
265312-55-8.mol
More
Less

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Property

Boiling point:
463.8±45.0 °C(Predicted)
Density 
1.416±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
Soluble to 20 mM in DMSO and to 5 mM in ethanol
form 
Black-purple solid
pka
-1.63±0.20(Predicted)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
219478
Product name
Cdk4 Inhibitor III - CAS 265312-55-8 - Calbiochem
Packaging
5mg
Price
$245
Updated
2024/03/01
Cayman Chemical
Product number
16614
Product name
Ryuvidine
Purity
≥95%
Packaging
1mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
16614
Product name
Ryuvidine
Purity
≥95%
Packaging
5mg
Price
$96
Updated
2024/03/01
Cayman Chemical
Product number
16614
Product name
Ryuvidine
Purity
≥95%
Packaging
10mg
Price
$160
Updated
2024/03/01
Cayman Chemical
Product number
16614
Product name
Ryuvidine
Purity
≥95%
Packaging
25mg
Price
$317
Updated
2024/03/01
More
Less

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Chemical Properties,Usage,Production

Uses

Ryuvidine is an antifungal agent used against pathogenic fungi.

Definition

ChEBI: 2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione is an aminotoluene.

General Description

A cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 μM for Cdk4/D1 and >200 μM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 μg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).

Biological Activity

Cyclin-dependent kinase (cdk) 4 inhibitor (IC 50 = 6.0 μ M at cdk4/cyclin D1) that displays > 33-fold selectivity over cdk2 (IC 50 > 200 μ M at cdk2/cyclin A). Cytotoxic against a range of human cancer cells (IC 50 values are 0.30, 0.61, 1.08 and 1.21 μ g/mL for HL-60, A549, Col 1 and HepG2 cells respectively).

Biochem/physiol Actions

Cell permeable: yes

storage

Store at +4°C

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Suppliers

China 36 United Kingdom 1 United States 6 Global 43
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8449
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
Advantage
58
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
order@changyanchem.com
Country
China
ProdList
5008
Advantage
55
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9414
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11289
Advantage
58
Shanghai Jiegu Biotechnology Co., Ltd.
Tel
021-51698675
Email
jiejiegroup@126.com
Country
China
ProdList
4112
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
3696
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58

265312-55-8, 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONERelated Search:

1-(2-METHYL-1,3-THIAZOL-4-YL)ETHANONE 4,5-THIAZOLEDICARBOXALDEHYDE 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE

  • 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
  • RYUVIDINE
  • Cdk4 Inhibitor III
  • 2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione
  • 4,7-Benzothiazoledione, 2-methyl-5-[(4-methylphenyl)amino]-
  • 2-methyl-5-[(4-methylphenyl)amino]benzothiazole-4,7-dione
  • 265312-55-8
  • C15H13N2O2S