ChemicalBook > CAS DataBase List > 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE

Product Name
2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
CAS No.
265312-55-8
Chemical Name
2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
Synonyms
RYUVIDINE;Cdk4 Inhibitor III;2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione;2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE;2-methyl-5-[(4-methylphenyl)amino]benzothiazole-4,7-dione;4,7-Benzothiazoledione, 2-methyl-5-[(4-methylphenyl)amino]-
CBNumber
CB92453429
Molecular Formula
C15H12N2O2S
Formula Weight
284.33
MOL File
265312-55-8.mol
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2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Property

Boiling point:
463.8±45.0 °C(Predicted)
Density 
1.416±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
Soluble to 20 mM in DMSO and to 5 mM in ethanol
form 
Black-purple solid
pka
-1.63±0.20(Predicted)
color 
Brown to black
InChI
InChI=1S/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3
InChIKey
HFPLHASLIOXVGS-UHFFFAOYSA-N
SMILES
C12N=C(SC=1C(=O)C=C(NC1C=CC(C)=CC=1)C2=O)C
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
219478
Product name
Cdk4 Inhibitor III - CAS 265312-55-8 - Calbiochem
Packaging
5mg
Price
$252
Updated
2025/07/31
Cayman Chemical
Product number
16614
Product name
Ryuvidine
Purity
≥95%
Packaging
1mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
16614
Product name
Ryuvidine
Purity
≥95%
Packaging
5mg
Price
$96
Updated
2024/03/01
Cayman Chemical
Product number
16614
Product name
Ryuvidine
Purity
≥95%
Packaging
10mg
Price
$160
Updated
2024/03/01
Cayman Chemical
Product number
16614
Product name
Ryuvidine
Purity
≥95%
Packaging
25mg
Price
$317
Updated
2024/03/01
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2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Chemical Properties,Usage,Production

Uses

Ryuvidine is an antifungal agent used against pathogenic fungi.

Definition

ChEBI: 2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione is an aminotoluene.

General Description

A cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 μM for Cdk4/D1 and >200 μM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 μg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).

Biological Activity

Cyclin-dependent kinase (cdk) 4 inhibitor (IC 50 = 6.0 μ M at cdk4/cyclin D1) that displays > 33-fold selectivity over cdk2 (IC 50 > 200 μ M at cdk2/cyclin A). Cytotoxic against a range of human cancer cells (IC 50 values are 0.30, 0.61, 1.08 and 1.21 μ g/mL for HL-60, A549, Col 1 and HepG2 cells respectively).

Biochem/physiol Actions

Cell permeable: yes

storage

Store at +4°C

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Suppliers

China 53 United Kingdom 1 United States 7 Global 61
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265312-55-8, 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONERelated Search:

1-(2-METHYL-1,3-THIAZOL-4-YL)ETHANONE 4,5-THIAZOLEDICARBOXALDEHYDE 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE

  • 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
  • RYUVIDINE
  • Cdk4 Inhibitor III
  • 2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione
  • 4,7-Benzothiazoledione, 2-methyl-5-[(4-methylphenyl)amino]-
  • 2-methyl-5-[(4-methylphenyl)amino]benzothiazole-4,7-dione
  • 265312-55-8
  • C15H13N2O2S