2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE

ChemicalBook > CAS DataBase List > 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE

Product Name: 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
CAS No.: 265312-55-8
Chemical Name: 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
Synonyms: RYUVIDINE;Cdk4 Inhibitor III;2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione;2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE;2-methyl-5-[(4-methylphenyl)amino]benzothiazole-4,7-dione;4,7-Benzothiazoledione, 2-methyl-5-[(4-methylphenyl)amino]-
CBNumber: CB92453429
Molecular Formula: C15H12N2O2S
Formula Weight: 284.33
MOL File: 265312-55-8.mol

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2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Property

Boiling point:: 463.8±45.0 °C(Predicted)
Density: 1.416±0.06 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: Soluble to 20 mM in DMSO and to 5 mM in ethanol
form: Black-purple solid
pka: -1.63±0.20(Predicted)
color: Brown to black

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 219478
Product name: Cdk4 Inhibitor III - CAS 265312-55-8 - Calbiochem
Packaging: 5mg
Price: $245
Updated: 2024/03/01

Cayman Chemical

Product number: 16614
Product name: Ryuvidine
Purity: ≥95%
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 16614
Product name: Ryuvidine
Purity: ≥95%
Packaging: 5mg
Price: $96
Updated: 2024/03/01

Cayman Chemical

Product number: 16614
Product name: Ryuvidine
Purity: ≥95%
Packaging: 10mg
Price: $160
Updated: 2024/03/01

Cayman Chemical

Product number: 16614
Product name: Ryuvidine
Purity: ≥95%
Packaging: 25mg
Price: $317
Updated: 2024/03/01

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2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Chemical Properties,Usage,Production

Uses

Ryuvidine is an antifungal agent used against pathogenic fungi.

Definition

ChEBI: 2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione is an aminotoluene.

General Description

A cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC₅₀ = 6.0 μM for Cdk4/D1 and >200 μM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC₅₀ = 0.61, 1.08, 0.30, and 1.21 μg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).

Biological Activity

Cyclin-dependent kinase (cdk) 4 inhibitor (IC 50 = 6.0 μ M at cdk4/cyclin D1) that displays > 33-fold selectivity over cdk2 (IC 50 > 200 μ M at cdk2/cyclin A). Cytotoxic against a range of human cancer cells (IC 50 values are 0.30, 0.61, 1.08 and 1.21 μ g/mL for HL-60, A549, Col 1 and HepG2 cells respectively).

Biochem/physiol Actions

Cell permeable: yes

storage

Store at +4°C

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Preparation Products And Raw materials

Raw materials

Preparation Products

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265312-55-8, 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONERelated Search:

1-(2-METHYL-1,3-THIAZOL-4-YL)ETHANONE 4,5-THIAZOLEDICARBOXALDEHYDE 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE

RYUVIDINE

Cdk4 Inhibitor III

2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione

4,7-Benzothiazoledione, 2-methyl-5-[(4-methylphenyl)amino]-

2-methyl-5-[(4-methylphenyl)amino]benzothiazole-4,7-dione

265312-55-8

C15H13N2O2S