4-(4-CHLORO-6-(2-(DIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-1-YL)-1,3,5-TRIAZIN-2-YL)MORPHOLINE
- Product Name
- 4-(4-CHLORO-6-(2-(DIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-1-YL)-1,3,5-TRIAZIN-2-YL)MORPHOLINE
- CAS No.
- 475111-38-7
- Chemical Name
- 4-(4-CHLORO-6-(2-(DIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-1-YL)-1,3,5-TRIAZIN-2-YL)MORPHOLINE
- Synonyms
- EOS-60790;-1,3,5-triazin-2-yl);-1H-benzo[d]imidazol-1-yl);4-(4-Chloro-6-(2-(difluoromethyl);Oxazole,2-(chloromethyl)-8-methyl-;Ethanone,2-bromo-1-[7-(trifluoromethyl)phenyl]-;1-[4-chloro-6-(Morpholin-4-yl)-1,3,5-triazin-2-yl]-2-(difluoroMethyl)-1H-1,3-be;1-(4-chloro-6-Morpholino-1,3,5-triazin-2-yl)-2-(difluoroMethyl)-1H-benzo[d]iMidazole;1-[4-chloro-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-(difluoromethyl)-1H-Benzimidazole;1H-Benzimidazole, 1-[4-chloro-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-(difluoromethyl)-
- CBNumber
- CB92454709
- Molecular Formula
- C15H13ClF2N6O
- Formula Weight
- 366.75
- MOL File
- 475111-38-7.mol
4-(4-CHLORO-6-(2-(DIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-1-YL)-1,3,5-TRIAZIN-2-YL)MORPHOLINE Property
- Melting point:
- 230-231 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 583.0±60.0 °C(Predicted)
- Density
- 1.65±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.53±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P222Do not allow contact with air.
P231Handle under inert gas.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P422Store contents under …
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 092514
- Product name
- 4-(4-Chloro-6-(2-(difluoromethyl)-1H-benzo[d]-imidazol-1-yl)-1,3,5-triazin-2-yl)morpholine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $756
- Updated
- 2021/12/16
- Product number
- 092514
- Product name
- 4-(4-Chloro-6-(2-(difluoromethyl)-1H-benzo[d]-imidazol-1-yl)-1,3,5-triazin-2-yl)morpholine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $341
- Updated
- 2021/12/16
- Product number
- 6479AB
- Product name
- 4-(4-Chloro-6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazin-2-yl)morpholine
- Packaging
- 250mg
- Price
- $371
- Updated
- 2021/12/16
- Product number
- HCH0050020
- Product name
- 4-(4-CHLORO-6-(2-(DIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-1-YL)-1,3,5-TRIAZIN-2-YL)MORPHOLINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $3811.5
- Updated
- 2021/12/16
- Product number
- 61-2532
- Product name
- 4-(4-Chloro-6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazin-2-yl)morpholine
- Purity
- 95%-98%
- Packaging
- 0.25g
- Price
- $405
- Updated
- 2021/12/16
4-(4-CHLORO-6-(2-(DIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-1-YL)-1,3,5-TRIAZIN-2-YL)MORPHOLINE Chemical Properties,Usage,Production
Synthesis
6601-22-5
705-09-9
475111-38-7
The reaction was carried out with 2-(difluoromethyl)-1H-benzo[d]imidazole (67.0 g, 400 mmol) and 2,4-dichloro-6-morpholino-1,3,5-triazine (94.0 g, 400 mmol) as raw materials in the presence of anhydrous potassium carbonate (221.1 g, 1600 mmol), stirred for 4 hours at room temperature in DMF (1.60 L). Upon completion of the reaction, the mixture was poured into water and a white precipitate was precipitated. The precipitate was collected by filtration and washed sequentially with DMF and acetone. Subsequently, the solid was dried under reduced pressure to afford the white crystalline product 4-(4-chloro-6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazin-2-yl)morpholine (131.5 g, 358.6 mmol) in 90% yield. Mass spectral analysis showed m/z: 366 (M+). 1H-NMR (CDCl3) data were as follows: δ 3.80-3.87 (4H, m), 3.94-4.01 (4H, m), 7.38-7.53 (2H, m), 7.58 (1H, t, J=54 Hz), 7.90 (1H, d, J=7 Hz), 8.42 (1H, d J=7Hz).
References
[1] Patent: US2007/244110, 2007, A1. Location in patent: Page/Page column 4
[2] Patent: WO2014/164942, 2014, A1. Location in patent: Paragraph 0206-0207
[3] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 2, p. 206 - 210
[4] Patent: WO2014/5182, 2014, A1. Location in patent: Page/Page column 40
[5] Patent: WO2011/114275, 2011, A1. Location in patent: Page/Page column 74
4-(4-CHLORO-6-(2-(DIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-1-YL)-1,3,5-TRIAZIN-2-YL)MORPHOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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