ChemicalBook > CAS DataBase List > 4-(4-CHLORO-6-(2-(DIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-1-YL)-1,3,5-TRIAZIN-2-YL)MORPHOLINE

4-(4-CHLORO-6-(2-(DIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-1-YL)-1,3,5-TRIAZIN-2-YL)MORPHOLINE

Product Name: 4-(4-CHLORO-6-(2-(DIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-1-YL)-1,3,5-TRIAZIN-2-YL)MORPHOLINE
CAS No.: 475111-38-7
Chemical Name: 4-(4-CHLORO-6-(2-(DIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-1-YL)-1,3,5-TRIAZIN-2-YL)MORPHOLINE
Synonyms: EOS-60790;-1,3,5-triazin-2-yl);-1H-benzo[d]imidazol-1-yl);4-(4-Chloro-6-(2-(difluoromethyl);Oxazole,2-(chloromethyl)-8-methyl-;Ethanone,2-bromo-1-[7-(trifluoromethyl)phenyl]-;1-[4-chloro-6-(Morpholin-4-yl)-1,3,5-triazin-2-yl]-2-(difluoroMethyl)-1H-1,3-be;1-(4-chloro-6-Morpholino-1,3,5-triazin-2-yl)-2-(difluoroMethyl)-1H-benzo[d]iMidazole;1-[4-chloro-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-(difluoromethyl)-1H-Benzimidazole;1H-Benzimidazole, 1-[4-chloro-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-(difluoromethyl)-
CBNumber: CB92454709
Molecular Formula: C15H13ClF2N6O
Formula Weight: 366.75
MOL File: 475111-38-7.mol

Less

4-(4-CHLORO-6-(2-(DIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-1-YL)-1,3,5-TRIAZIN-2-YL)MORPHOLINE Property

Melting point:: 230-231 °C(Solv: ethanol (64-17-5))
Boiling point:: 583.0±60.0 °C(Predicted)
Density: 1.65±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 1.53±0.10(Predicted)
Appearance: White to off-white Solid

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P222Do not allow contact with air.

P231Handle under inert gas.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P422Store contents under …

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Matrix Scientific

Product number: 092514
Product name: 4-(4-Chloro-6-(2-(difluoromethyl)-1H-benzo[d]-imidazol-1-yl)-1,3,5-triazin-2-yl)morpholine
Purity: 95+%
Packaging: 1g
Price: $756
Updated: 2021/12/16

Matrix Scientific

Product number: 092514
Product name: 4-(4-Chloro-6-(2-(difluoromethyl)-1H-benzo[d]-imidazol-1-yl)-1,3,5-triazin-2-yl)morpholine
Purity: 95+%
Packaging: 250mg
Price: $341
Updated: 2021/12/16

AK Scientific

Product number: 6479AB
Product name: 4-(4-Chloro-6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazin-2-yl)morpholine
Packaging: 250mg
Price: $371
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0050020
Product name: 4-(4-CHLORO-6-(2-(DIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-1-YL)-1,3,5-TRIAZIN-2-YL)MORPHOLINE
Purity: 95.00%
Packaging: 5G
Price: $3811.5
Updated: 2021/12/16

Abosyn

Product number: 61-2532
Product name: 4-(4-Chloro-6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazin-2-yl)morpholine
Purity: 95%-98%
Packaging: 0.25g
Price: $405
Updated: 2021/12/16

Less

4-(4-CHLORO-6-(2-(DIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-1-YL)-1,3,5-TRIAZIN-2-YL)MORPHOLINE Chemical Properties,Usage,Production

Synthesis

6601-22-5

705-09-9

475111-38-7

The reaction was carried out with 2-(difluoromethyl)-1H-benzo[d]imidazole (67.0 g, 400 mmol) and 2,4-dichloro-6-morpholino-1,3,5-triazine (94.0 g, 400 mmol) as raw materials in the presence of anhydrous potassium carbonate (221.1 g, 1600 mmol), stirred for 4 hours at room temperature in DMF (1.60 L). Upon completion of the reaction, the mixture was poured into water and a white precipitate was precipitated. The precipitate was collected by filtration and washed sequentially with DMF and acetone. Subsequently, the solid was dried under reduced pressure to afford the white crystalline product 4-(4-chloro-6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazin-2-yl)morpholine (131.5 g, 358.6 mmol) in 90% yield. Mass spectral analysis showed m/z: 366 (M+). 1H-NMR (CDCl3) data were as follows: δ 3.80-3.87 (4H, m), 3.94-4.01 (4H, m), 7.38-7.53 (2H, m), 7.58 (1H, t, J=54 Hz), 7.90 (1H, d, J=7 Hz), 8.42 (1H, d J=7Hz).

References

[1] Patent: US2007/244110, 2007, A1. Location in patent: Page/Page column 4
[2] Patent: WO2014/164942, 2014, A1. Location in patent: Paragraph 0206-0207
[3] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 2, p. 206 - 210
[4] Patent: WO2014/5182, 2014, A1. Location in patent: Page/Page column 40
[5] Patent: WO2011/114275, 2011, A1. Location in patent: Page/Page column 74

4-(4-CHLORO-6-(2-(DIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-1-YL)-1,3,5-TRIAZIN-2-YL)MORPHOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

4-(4-CHLORO-6-(2-(DIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-1-YL)-1,3,5-TRIAZIN-2-YL)MORPHOLINE Suppliers

China 48 India 1 United States 4 Global 53

Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Tel: 21-57721279
Fax: QQ：14057904
Email: sales@shydchem.com.cn
Country: China
ProdList: 998
Advantage: 56

Shanghai Paulshine Chemical Co., Ltd.

Tel: +86-021-37788663
Fax: +86-021-37788663
Country: China
ProdList: 186
Advantage: 64

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
Advantage: 55

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Changzhou Tianrui Pharmaceutical Technology Co., Ltd.

Tel: 0519-85386832 13382812559
Fax: 0519-85386832
Email: sales@cztrchem.com
Country: China
ProdList: 1185
Advantage: 56

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

Shanghai XingMo Biotechnology Co., Ltd.

Tel: +86 13524779951; 13524779951
Fax: QQ: 2075692521
Email: 2075692521@qq.com
Country: China
ProdList: 310
Advantage: 55

Shanghai GaoDao Pharmaceutical Co., Ltd.

Tel: 021-15001867143 15001867143
Fax: -
Email: 1095570358@qq.com
Country: China
ProdList: 909
Advantage: 55

Lanzhou Angeli Biochemical Technology Co., Ltd.

Tel: 0931-8235634 13321316780
Fax: +86(931) 4873122
Email: 1455540579@qq.com
Country: China
ProdList: 958
Advantage: 55

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 7218
Advantage: 58

Jinan elephant international trading co., LTD

Tel
Fax: -
Email: 13006575422@163.com
Country: China
ProdList: 6355
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

Biokitchen

Tel: 021-021-021-31663258 13795219287
Fax: 021-31663258
Email: donghuanwen@126.com
Country: China
ProdList: 8816
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: (5)02557626880
Email: dt3@aikonchem.com
Country: China
ProdList: 15493
Advantage: 58

Bejing Famous Pharmaceutical Technology Co., Ltd.

Tel: 13331045123
Fax: 86-10-80339217
Email: 2559355526@qq.com
Country: China
ProdList: 14193
Advantage: 58

Nanjing crow LuNing pharmaceutical technology co., LTD

Tel: 13382066392
Country: CHINA
ProdList: 4877
Advantage: 58

Shanghai zhigan biotechnology co., LTD

Tel
Email: zhiqianbio@126.com
Country: China
ProdList: 19778
Advantage: 58

Allfluoro pharmaceutical co. ltd.

Tel: +86-400-0216110 +86-15958047586
Fax: 0086-21-33275002
Email: sales@allfluoro.com
Country: China
ProdList: 11385
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Henan Weitesi Chemical Technology Co. LTD

Tel: 0371-0371-55135753 18003832934
Fax: QQ：2853979818
Email: 2853979818@qq.com
Country: China
ProdList: 9991
Advantage: 58

Shanghai Dexuan Pharmaceutical Technology Co., Ltd

Tel: 1701086315
Fax: 1701086315@qq.com
Email: dexuanpharma@126.com
Country: China
ProdList: 9475
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Shanghai UCHEM Inc.

Tel: 18939844854
Fax: QQ3004479448
Email: sales6@myuchem.com
Country: China
ProdList: 4997
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Beijing Stronger Science Co., Ltd.

Tel: 0531-88924771 15614660963
Email: elsa.hang@strongerscience.com
Country: China
ProdList: 10623
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

Affinity（Wuhan）Ltd.

Tel: 15841022315
Email: sales@affinitytech.cn
Country: China
ProdList: 3000
Advantage: 58

Jiaxing Zhejia Biotechnology Co., LTD

Tel: 0573-85609002 18367600069;
Email: zhejia01@163.com
Country: China
ProdList: 8886
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9960
Advantage: 58

Shanghai Lingfu Pharmaceutical Research Co. LTD

Tel: +86(21)5895 0110 19945755304
Email: sales@chemany.com
Country: China
ProdList: 9984
Advantage: 58

Hangzhou Hongxi Biomedical Technology Co., LTD

Tel: 18989489206
Email: hoxipharm@163.com
Country: China
ProdList: 4921
Advantage: 58

Suzhou Meishi Biotechnology Co., Ltd.

Tel: 1173954148q
Email: meishipharma@126.com
Country: China
ProdList: 20033
Advantage: 58

Shanghai Jieshikai Biotechnology Co. , Ltd.

Tel: 021-57520305 13795461237
Email: zhuruyan@jskchem.com
Country: China
ProdList: 49234
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29995
Advantage: 58

Shanghai jerryxing Biomedical Technology Co., Ltd

Tel: 17721492509; 17721492509
Email: 643638326@qq.com
Country: China
ProdList: 4970
Advantage: 58

Nantong Hanfang Biotechnology Co. , Ltd.

Tel: hanfangpharma@126.com; 18616537568
Email: hanfangpharma@126.com
Country: China
ProdList: 29965
Advantage: 58

Olix (Shanghai) Pharmaceutical Technology Co., Ltd

Tel: 17316404525 17316404525
Email: 209533805@qq.com
Country: China
ProdList: 9766
Advantage: 58

GIHI CHEMICALS CO.,LIMITED

Tel: +8618058761490
Email: info@gihichemicals.com
Country: China
ProdList: 49941
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Shanghai Paulshinechem Co., Ltd.

Tel: --
Fax: --
Country: China
ProdList: 38
Advantage: 50

Shanghai Biochempartner Co., Ltd.

Tel: --
Fax: --
Country: China
ProdList: 757
Advantage: 50

475111-38-7, 4-(4-CHLORO-6-(2-(DIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-1-YL)-1,3,5-TRIAZIN-2-YL)MORPHOLINERelated Search:

TRIETAZINE-DESETHYL 4-(4-CHLORO-6-(2-(DIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-1-YL)-1,3,5-TRIAZIN-2-YL)MORPHOLINE

1-[4-chloro-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-(difluoromethyl)-1H-Benzimidazole

1-[4-chloro-6-(Morpholin-4-yl)-1,3,5-triazin-2-yl]-2-(difluoroMethyl)-1H-1,3-benzodiazole

1-(4-chloro-6-Morpholino-1,3,5-triazin-2-yl)-2-(difluoroMethyl)-1H-benzo[d]iMidazole

-1,3,5-triazin-2-yl)

-1H-benzo[d]imidazol-1-yl)

4-(4-Chloro-6-(2-(difluoromethyl)

4-(4-CHLORO-6-(2-(DIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-1-YL)-1,3,5-TRIAZIN-2-YL)MORPHOLINE

EOS-60790

1-[4-chloro-6-(Morpholin-4-yl)-1,3,5-triazin-2-yl]-2-(difluoroMethyl)-1H-1,3-be

1H-Benzimidazole, 1-[4-chloro-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-(difluoromethyl)-

Oxazole,2-(chloromethyl)-8-methyl-

Ethanone,2-bromo-1-[7-(trifluoromethyl)phenyl]-

475111-38-7

C15H13ClF2N6O