(6-TERT-BUTOXYCARBONYLAMINO-PYRIDIN-2-YL)-ACETIC ACID ETHYL ESTER
- Product Name
- (6-TERT-BUTOXYCARBONYLAMINO-PYRIDIN-2-YL)-ACETIC ACID ETHYL ESTER
- CAS No.
- 408365-87-7
- Chemical Name
- (6-TERT-BUTOXYCARBONYLAMINO-PYRIDIN-2-YL)-ACETIC ACID ETHYL ESTER
- Synonyms
- Ethyl 2-(6-((tert-butoxycarbonyl);Ethyl 2-[6-(Boc-amino)-2-pyridyl]acetate;tert-Butyl 6-(2-ethoxy-2-oxoethyl)picolinate;ethyl 2-(6-(tert-butoxycarbonyl)pyridin-2-yl)acetate;Ethyl [6-[(tert-butoxycarbonyl)amino]-2-pyridinyl]acetate;(6-TERT-BUTOXYCARBONYLAMINO-PYRIDIN-2-YL)-ACETIC ACID ETHYL ESTER;ethyl 2-[6-[(2-methylpropan-2-yl)oxycarbonylamino]pyridin-2-yl]acetate;ethyl 2-(6-{[(tert-butoxy)carbonyl]amino}pyridin-2-yl)acetate - [E72440];2-PYRIDINEACETIC ACID,6-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-,ETHYL ESTER
- CBNumber
- CB92456778
- Molecular Formula
- C14H20N2O4
- Formula Weight
- 280.32
- MOL File
- 408365-87-7.mol
(6-TERT-BUTOXYCARBONYLAMINO-PYRIDIN-2-YL)-ACETIC ACID ETHYL ESTER Property
- Boiling point:
- 344.6±32.0 °C(Predicted)
- Density
- 1.163±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 12.39±0.70(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CHM0094483
- Product name
- 2-PYRIDINEACETIC ACID,6-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-,ETHYL ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.83
- Updated
- 2021/12/16
- Product number
- CD11127648
- Product name
- Ethyl2-(6-((tert-butoxycarbonyl)amino)pyridin-2-yl)acetate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $713
- Updated
- 2021/12/16
- Product number
- 408365877
- Product name
- Ethyl2-(6-((tert-butoxycarbonyl)amino)pyridin-2-yl)acetate
- Packaging
- 10g
- Price
- $748.8
- Updated
- 2021/12/16
- Product number
- SC-22905
- Product name
- ethyl2-(6-(tert-butoxycarbonylamino)pyridin-2-yl)acetate
- Purity
- 95
- Packaging
- 1g
- Price
- $899
- Updated
- 2021/12/16
- Product number
- A244406
- Product name
- Ethyl2-(6-((tert-butoxycarbonyl)amino)pyridin-2-yl)acetate
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $40
- Updated
- 2021/12/16
(6-TERT-BUTOXYCARBONYLAMINO-PYRIDIN-2-YL)-ACETIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Synthesis
90101-22-7
105-58-8
408365-87-7
The general procedure for the synthesis of ethyl [6-[(tert-butoxycarbonyl)amino]-2-pyridinyl]acetate from tert-butyl (6-methylpyridin-2-yl)carbamate and diethyl carbonate was as follows: to an anhydrous THF solution of tert-butyl (6-methylpyridin-2-yl)carbamate (0.97 g, 4.66 mmol) was slowly added, at -78 °C, LDA (1.8 M heptane solution, 4 equiv, 18.6 mmol) and the reaction mixture was stirred for 30 min. Subsequently, diethyl carbonate (2 eq., 9.32 mmol) was added and stirring was continued at -78 °C for 10 min. The reaction mixture was slowly warmed to 0 °C and stirring was continued at this temperature for 2 hours. Upon completion of the reaction, the reaction was quenched with saturated NH4Cl solution followed by extraction of the reaction mixture with ethyl acetate. The organic phases were combined, dried with anhydrous MgSO4 and concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography with heptane/ethyl acetate as eluent (gradient from 98:2 to 95:5) to afford the target product [6-[(tert-butoxycarbonyl)amino]-2-pyridinyl]ethyl acetate (1.36 g in >100% yield, probably due to incomplete removal of trace solvent).
References
[1] Patent: WO2006/50908, 2006, A1. Location in patent: Page/Page column 32; 39-40
[2] Patent: WO2014/182829, 2014, A1. Location in patent: Page/Page column 62; 63
[3] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 11, p. 2771 - 2775
(6-TERT-BUTOXYCARBONYLAMINO-PYRIDIN-2-YL)-ACETIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
(6-TERT-BUTOXYCARBONYLAMINO-PYRIDIN-2-YL)-ACETIC ACID ETHYL ESTER Suppliers
- Tel
- 0535-6385396
- Fax
- +86 (535) 638-9971
- info@carbottpharm.com
- Country
- China
- ProdList
- 957
- Advantage
- 56
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10263
- Advantage
- 55
- Tel
- 13564638271
- Fax
- 021-68948280
- shhjiang1977@163.com
- Country
- China
- ProdList
- 2987
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 13764058804
- 3438424070@qq.com
- Country
- China
- ProdList
- 376
- Advantage
- 58
- Tel
- 025-66061636 18013972705
- Fax
- (3)02557626880
- qqyang@aikonchem.com
- Country
- China
- ProdList
- 15814
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- +862156762820 +86-13564624040
- sales@myuchem.com
- Country
- China
- ProdList
- 8460
- Advantage
- 58
- Tel
- +86-0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25356
- Advantage
- 58