TETRABENAZINE
- Product Name
- TETRABENAZINE
- CAS No.
- 718635-93-9
- Chemical Name
- TETRABENAZINE
- Synonyms
- Dolalgial;TETRABENAZINE（b）;rac-Tetrabenazine;Ro 1-9569 Racemate;Cis Trans Tetrabenazine;Tetrabenazine (Racemate);Tetrabenazine Impurity 10;Tetrabenazine Impurity 46;Tetrabenazine Racemate, >98%;TETRABENAZINE RACEMATE;RO 1-9569 RACEMATE
- CBNumber
- CB92457043
- Molecular Formula
- C19H27NO3
- Formula Weight
- 317.42
- MOL File
- 718635-93-9.mol
TETRABENAZINE Property
- Melting point:
- 125 °C
- Boiling point:
- 448.9±45.0 °C(Predicted)
- Density
- 1.12±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥ 3.2 mg/mL (10.08 mM)
- form
- Solid
- pka
- 6.46±0.40(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- T889552
- Product name
- Tetrabenazine
- Packaging
- 5mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-5700
- Product name
- Tetrabenazine(Racemate)
- Purity
- >98.0%
- Packaging
- 25mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-5700
- Product name
- Tetrabenazine(Racemate)
- Purity
- >98.0%
- Packaging
- 50mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-5700
- Product name
- Tetrabenazine(Racemate)
- Purity
- >98.0%
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- CD11067653
- Product name
- TetrabenazineRacemate
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $247
- Updated
- 2021/12/16
TETRABENAZINE Chemical Properties,Usage,Production
Uses
Tetrabenazine is a dopamine depleting medication for the treatment of chorea in Huntington’s disease.
Definition
ChEBI: 9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one is a benzoquinolizine that is 1,2,3,4,4a,9,10,10a-octahydrophenanthrene in which the carbon at position 10a is replaced by a nitrogen and which is substituted by an isobutyl group at position 2, an oxo group at position 3, and methoxy groups at positions 6 and 7. It is a benzoquinolizine, a cyclic ketone and a tertiary amino compound.
Synthesis
91342-74-4
20232-39-7
718635-93-9
6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride (118.2 kg) was dissolved in water (3 volumes). A solution of 3-((dimethylamino)methyl)-5-methylhexan-2-one (99.1 kg) in n-heptane (1.5 vol) was added, and the reaction mixture was stirred vigorously at 35 °C for at least 48 hours until the amount of 6,7-dimethoxy-3,4-dihydroisoquinoline was reduced to less than 10% of the initial amount (as detected by a standard solution). After completion of the reaction, the solid product was collected by filtration, washed sequentially with water and n-heptane, and then dried under vacuum to afford 3-isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one (141.1 kg, 85.6% yield).
References
[1] Patent: US2017/183346, 2017, A1. Location in patent: Paragraph 0165
[2] Patent: US2017/183346, 2017, A1. Location in patent: Paragraph 0162; 0164
[3] Patent: CN107698582, 2018, A. Location in patent: Paragraph 0019
[4] Journal of Labelled Compounds and Radiopharmaceuticals, 2011, vol. 54, # 7, p. 367 - 370
TETRABENAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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