2-BROMOMETHYL-4-CHLORO-BENZOIC ACID METHYL ESTER
- Product Name
- 2-BROMOMETHYL-4-CHLORO-BENZOIC ACID METHYL ESTER
- CAS No.
- 145908-29-8
- Chemical Name
- 2-BROMOMETHYL-4-CHLORO-BENZOIC ACID METHYL ESTER
- Synonyms
- Methyl 2-(broMoMethyl)-4-chlorobenzoate;2-BROMOMETHYL-4-CHLORO-BENZOIC ACID METHYL ESTER;Benzoic acid, 2-(broMoMethyl)-4-chloro-, Methyl ester
- CBNumber
- CB92457629
- Molecular Formula
- C9H8BrClO2
- Formula Weight
- 263.52
- MOL File
- 145908-29-8.mol
2-BROMOMETHYL-4-CHLORO-BENZOIC ACID METHYL ESTER Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
Safety
- RIDADR
- 3261
- HazardClass
- 8
- PackingGroup
- Ⅱ
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M296178
- Product name
- Methyl2-(bromomethyl)-4-chlorobenzoate
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- W3187
- Product name
- Methyl2-(bromomethyl)-4-chlorobenzoate
- Packaging
- 1g
- Price
- $58
- Updated
- 2021/12/16
- Product number
- FB153931
- Product name
- 2-(Bromomethyl)-4-chloro-benzoic acid methyl ester
- Packaging
- 2g
- Price
- $151
- Updated
- 2021/12/16
- Product number
- 075674
- Product name
- Methyl 2-bromomethyl-4-chlorobenzoate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $297
- Updated
- 2021/12/16
- Product number
- FB153931
- Product name
- 2-(Bromomethyl)-4-chloro-benzoic acid methyl ester
- Packaging
- 5G
- Price
- $302
- Updated
- 2021/12/16
2-BROMOMETHYL-4-CHLORO-BENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production
Synthesis
99585-12-3
145908-29-8
Methyl 4-chloro-2-methylbenzoate (10.86 g, 58.8 mmol, 1.0 eq.) was used as the starting material and dissolved in carbon tetrachloride (100 mL). N-bromosuccinimide (15.7 g, 88.2 mmol, 1.5 eq.) and benzoyl peroxide (0.05 g) were added sequentially. The reaction mixture was heated to reflux overnight. After completion of the reaction, the reaction mixture was filtered and the solids were washed with dichloromethane. The organic filtrates were combined, concentrated and dried to afford the target product methyl 2-bromomethyl-4-chlorobenzoate (7.1 g, 45.8% yield). The structure of the product was confirmed by 1H NMR.
References
[1] Patent: US2005/143348, 2005, A1. Location in patent: Page/Page column 45; 49; 55
[2] Patent: US2005/239838, 2005, A1. Location in patent: Page/Page column 41
[3] Patent: WO2005/54176, 2005, A1. Location in patent: Page/Page column 136
[4] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 5, p. 1628 - 1631
[5] Patent: US2009/270393, 2009, A1. Location in patent: Page/Page column 43-44
2-BROMOMETHYL-4-CHLORO-BENZOIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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