OTAVA-BB BB7118560909
- Product Name
- OTAVA-BB BB7118560909
- CAS No.
- 3284-47-7
- Chemical Name
- OTAVA-BB BB7118560909
- Synonyms
- ethyl 3-methyl-1H-pyrrole-2-carboxylate;AKOS A0602-0540;OTAVA-BB BB7118560909;Ethyl 3-Methyl-1H-pyrrole...;Ethyl 3-Methylpyrrole-2-carboxylate;1H-PYRROLE-2-CARBOXYLIC ACID, 3-METHYL-;Ethyl 3-methyl-1H-pyrrole-2-carboxylate 98%;Pyrrole-2-carboxylic acid, 3-methyl-, ethyl ester;3-Methyl-1H-pyrrole-2-carboxylic acid ethyl ester;1H-PYRROLE-2-CARBOXYLIC ACID, 3-METHYL-, ETHYL ESTER
- CBNumber
- CB92463811
- Molecular Formula
- C8H11NO2
- Formula Weight
- 153.18
- MOL File
- 3284-47-7.mol
OTAVA-BB BB7118560909 Property
- Melting point:
- 56 °C
- Boiling point:
- 270-290 °C
- Density
- 1.106
- storage temp.
- 2-8°C
- pka
- 15.54±0.50(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C8H11NO2/c1-3-11-8(10)7-6(2)4-5-9-7/h4-5,9H,3H2,1-2H3
- InChIKey
- FGILMAYWLMWCQA-UHFFFAOYSA-N
- SMILES
- N1C=CC(C)=C1C(OCC)=O
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E926470
- Product name
- Ethyl3-methyl-1H-pyrrole-2-carboxylate
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- OR313039
- Product name
- Ethyl3-methyl-1H-pyrrole-2-carboxylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $109
- Updated
- 2021/12/16
- Product number
- 074519
- Product name
- Ethyl 3-methyl-1H-pyrrole-2-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- 4H23-1-8B
- Product name
- Ethyl 3-methyl-1H-pyrrole-2-carboxylate
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 074519
- Product name
- Ethyl 3-methyl-1H-pyrrole-2-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $148
- Updated
- 2021/12/16
OTAVA-BB BB7118560909 Chemical Properties,Usage,Production
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 28, p. 1671, 1991 DOI: 10.1002/jhet.5570280705
Tetrahedron Letters, 3, p. 921, 1962
Synthesis
3284-52-4
3284-47-7
The general procedure for the synthesis of ethyl 3-hydroxy-3-methyl-1-tosylpyrrolidine-2-carboxylate from ethyl 3-hydroxy-3-methyl-1-tosylpyrrolidine-2-carboxylate was as follows: 3-alkylpyrrole derivatives were prepared according to the procedure described in Scheme 1. First, ethyl glycinate 5 was treated with p-toluenesulfonyl chloride (Ts-Cl) to give intermediate 6. Subsequently, intermediate 6 was reacted in the presence of 4-diethylaminobutan-2-one and potassium tert-butanolate (t-BuOK) to produce intermediate 7. Next, intermediate 7 was dehydrated with phosphorus oxychloride (POCl3) to give dihydropyrrole derivative 8. In the presence of sodium ethanolate, the dihydropyrrole derivative was synthesized by an elimination reaction the dihydropyrrole derivative 8 was converted to pyrrole derivative 9. Then, the pyrrole nitrogen was deprotonated using sodium hydride (NaH) and an alkylation reaction was carried out to obtain intermediate 10. finally, the ester group was hydrolyzed by potassium hydroxide (KOH) in aqueous solution in methanol (MeOH), followed by the use of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDCI) to convert the corresponding acid 11 into the target amide products (81), (82) and (83).
References
[1] Patent: WO2009/23272, 2009, A1. Location in patent: Page/Page column 36
[2] Journal of Heterocyclic Chemistry, 1991, vol. 28, # 7, p. 1671 - 1676
[3] Patent: EP2612848, 2013, A1
[4] Patent: WO2009/117421, 2009, A2
OTAVA-BB BB7118560909 Preparation Products And Raw materials
Raw materials
Preparation Products
OTAVA-BB BB7118560909 Suppliers
- Tel
- --
- Fax
- --
- contact@ambinter.com
- Country
- France
- ProdList
- 1648
- Advantage
- 60
View Lastest Price from OTAVA-BB BB7118560909 manufacturers
- Product
- OTAVA-BB BB7118560909 3284-47-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-07-11
- Product
- Ethyl 3-methyl-1H-pyrrole-2-carboxylate 3284-47-7
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-08-05