Methyl 2-pyrrolecarboxylate
- Product Name
- Methyl 2-pyrrolecarboxylate
- CAS No.
- 1193-62-0
- Chemical Name
- Methyl 2-pyrrolecarboxylate
- Synonyms
- METHYL 1H-PYRROLE-2-CARBOXYLATE;RARECHEM AL BF 0174;2 - pyrrole Methyl forMate;METHYL 2-PYRROLECARBOXYLATE;MethylPyrrole-2-carboxylate>Methyl 1H-pyrrol-2-carboxylate;Methyl 2-pyrrolecarboxylate 97%;Pyrrole-2-carboxylic Acid Methyl Ester;1H-Pyrrole-2-carboxylic acid,methyl ester
- CBNumber
- CB5485404
- Molecular Formula
- C6H7NO2
- Formula Weight
- 125.13
- MOL File
- 1193-62-0.mol
Methyl 2-pyrrolecarboxylate Property
- Melting point:
- 74-78 °C(lit.)
- Boiling point:
- 104-105 °C(Press: 9 Torr)
- Density
- 1.184±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly)
- form
- Solid
- pka
- 15.16±0.50(Predicted)
- color
- Light Beige
- Water Solubility
- Soluble in water.
- InChI
- InChI=1S/C6H7NO2/c1-9-6(8)5-3-2-4-7-5/h2-4,7H,1H3
- InChIKey
- VONGYFFEWFJHNP-UHFFFAOYSA-N
- SMILES
- N1C=CC=C1C(OC)=O
- LogP
- 1.170
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 640425
- Product name
- Methyl 2-pyrrolecarboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $78.4
- Updated
- 2025/07/31
- Product number
- 640425
- Product name
- Methyl 2-pyrrolecarboxylate
- Purity
- 97%
- Packaging
- 25g
- Price
- $80.5
- Updated
- 2025/07/31
- Product number
- M2160
- Product name
- Methyl Pyrrole-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $42
- Updated
- 2025/07/31
- Product number
- M2160
- Product name
- Methyl Pyrrole-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $147
- Updated
- 2025/07/31
- Product number
- M329105
- Product name
- Methyl1H-Pyrrole-2-carboxylate
- Packaging
- 10g
- Price
- $95
- Updated
- 2021/12/16
Methyl 2-pyrrolecarboxylate Chemical Properties,Usage,Production
Description
Methyl 2-pyrrolecarboxylate is a crystalline or powder,It can be used as an organic reagent and can be obtained by the reaction of pyrrole with dimethyl carbonate.
Uses
Methyl 1H-Pyrrole-2-carboxylate is an intermediate used to prepare pyrrolyl aryl sulfones with activity against HIV-1. It is also used in the synthesis of diaryl pyrrolecarboxylates as combretastatin A-4/lamellarin T hybrids with anti-mitotic and cytotoxic activity.
Definition
ChEBI: Methyl 1H-pyrrole-2-carboxylate is a member of pyrroles.
Synthesis
67-56-1
634-97-9
1193-62-0
50 mL of SOCl2 was slowly added dropwise to a solution of pyrrole-2-carboxylic acid (1) (16.65 g, 0.15 mol) dissolved in 10 mL of MeOH at 0 °C for a controlled time of 30 min. Subsequently, the reaction mixture was warmed up to 35 °C with continuous stirring for 24 hours. Upon completion of the reaction, the solvent was removed by vacuum evaporation, and the resulting residue was purified by column chromatography with the eluent being a mixed solvent of ethyl acetate/petroleum ether, which ultimately afforded Intermediate 2 as a white solid in 85% yield with a melting point of 72-73 °C.
References
[1] Canadian Journal of Chemistry, 2002, vol. 80, # 12, p. 1662 - 1667
[2] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 22, p. 7091 - 7100
[3] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 20, p. 2997 - 3003
[4] Patent: EP1386913, 2004, A1. Location in patent: Page 88
[5] Patent: EP986382, 2008, B1. Location in patent: Page/Page column 23
Methyl 2-pyrrolecarboxylate Preparation Products And Raw materials
Raw materials
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View Lastest Price from Methyl 2-pyrrolecarboxylate manufacturers
- Product
- Methyl 2-pyrrolecarboxylate 1193-62-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 2000KGS
- Release date
- 2025-10-22
- Product
- Methyl 2-pyrrolecarboxylate 1193-62-0
- Price
- US $12.00-200.00/g
- Min. Order
- 5g
- Purity
- 99%
- Supply Ability
- 50
- Release date
- 2024-07-12
- Product
- METHYL 1H-PYRROLE-2-CARBOXYLATE 1193-62-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10