Ethyl 5-hydroxyindole-2-carboxylate

Product Name: Ethyl 5-hydroxyindole-2-carboxylate
CAS No.: 24985-85-1
Chemical Name: Ethyl 5-hydroxyindole-2-carboxylate
Synonyms: 5-HO-ICA-OEt;2-CARBETHOXY-5-HYDROXYINDOLE;ETHYL 5-HYDROXYINDOLE-2-CARBOXYLATE;Ethyl 5-hydroxy-1H-indole-2-carboxylate;Ethyl 5-hydroxyindole-2-carboxylate, 98+%;5-HYDOXYINDOLE-2-CARBOXYLIC ACID, ETHYL ESTER;5-Hydroxy-2-indolecarboxylic acid ethyl ester;5-HYDROXYINDOLE-2-CARBOXYLIC ACID ETHYL ESTER;5-HYDROXY-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER;1H-Indole-2-carboxylic acid, 5-hydroxy-, ethyl ester
CBNumber: CB9425479
Molecular Formula: C11H11NO3
Formula Weight: 205.21
MOL File: 24985-85-1.mol

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Ethyl 5-hydroxyindole-2-carboxylate Property

Melting point:: 150-151°C
Boiling point:: 410.4±25.0 °C(Predicted)
Density: 1.326±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 9.59±0.40(Predicted)
Appearance: Off-white to yellow Solid
Water Solubility: Insoluble in water.
BRN: 476925
CAS DataBase Reference: 24985-85-1(CAS DataBase Reference)
NIST Chemistry Reference: Ethyl 5-hydroxyindole-2-carboxylate(24985-85-1)

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Safety

Safety Statements: 22-24/25

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: H943360
Product name: 5-Hydroxy-1H-indole-2-carboxylicAcidEthylEster
Packaging: 100mg
Price: $95
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0027175
Product name: 5-HYDROXY-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER
Purity: 95.00%
Packaging: 1G
Price: $620.39
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0027175
Product name: 5-HYDROXY-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER
Purity: 95.00%
Packaging: 5G
Price: $832.63
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0027175
Product name: 5-HYDROXY-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER
Purity: 95.00%
Packaging: 10G
Price: $1166.13
Updated: 2021/12/16

Matrix Scientific

Product number: 131894
Product name: Ethyl5-hydroxy-1H-indole-2-carboxylate
Purity: 97%
Packaging: 10g
Price: $1890
Updated: 2021/12/16

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Ethyl 5-hydroxyindole-2-carboxylate Chemical Properties,Usage,Production

Uses

Ethyl 5-hydroxyindole-2-carboxylate is used as an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs.

Synthesis

37033-95-7

24985-85-1

General procedure for the synthesis of ethyl 5-hydroxyindole-2-carboxylate from ethyl 5-benzyloxyindole-2-carboxylate: ethyl 5-benzyloxyindole-2-carboxylate (10 g, 34 mmol) was dissolved in ethanol (250 mL), 10% Pd/C catalyst was added, and the hydrogenation reaction was carried out for 20 h at atmospheric pressure (using a double-walled balloon). Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate and filtered through diatomaceous earth to remove the catalyst. The filtrate was concentrated in vacuum to give ethyl 5-hydroxyindole-2-carboxylate (7 g, 99% yield) in brown solid form. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.86 (broad peak, 1H), 7.29 (d, J = 8.80 Hz, 1H), 7.11 (s, 1H), 7.06 (s, 1H), 6.94 (d, J = 8.70 Hz, 1H), 4.83 (broad peak, 1H), 4.42 (q, J = 7.09 Hz, 2H ), 1.41 (t, J = 7.08Hz, 3H).

References

[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 1, p. 5 - 8
[2] Patent: US6670388, 2003, B1. Location in patent: Page column 6
[3] Patent: US6469046, 2002, B1
[4] Patent: US6608059, 2003, B1
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 24, p. 10455 - 10463

Ethyl 5-hydroxyindole-2-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 5-hydroxyindole-2-carboxylate Suppliers

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View Lastest Price from Ethyl 5-hydroxyindole-2-carboxylate manufacturers

Career Henan Chemical Co

Product: Ethyl 5-hydroxyindole-2-carboxylate 24985-85-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2018-08-13

24985-85-1, Ethyl 5-hydroxyindole-2-carboxylateRelated Search:

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1H-Indole-2-carboxylic acid, 5-hydroxy-, ethyl ester

Ethyl 5-hydroxy-1H-indole-2-carboxylate

5-HYDROXY-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER

5-HYDROXYINDOLE-2-CARBOXYLIC ACID ETHYL ESTER

ETHYL 5-HYDROXYINDOLE-2-CARBOXYLATE

5-Hydroxy-2-indolecarboxylic acid ethyl ester

5-HYDOXYINDOLE-2-CARBOXYLIC ACID, ETHYL ESTER

2-CARBETHOXY-5-HYDROXYINDOLE

5-HO-ICA-OEt

Ethyl 5-hydroxyindole-2-carboxylate, 98+%

5-HYDROXYINDOLE-2-CARBOXYLIC ACID ETHYL ESTER(5OHI2CAEt)

5-Hydroxy-1H-indole-2-carboxylic acid ethyl ester, CAS 24985-85-1

24985-85-1

Indoles and derivatives