Ethyl 5-chloro-2-indolecarboxylate

Product Name: Ethyl 5-chloro-2-indolecarboxylate
CAS No.: 4792-67-0
Chemical Name: Ethyl 5-chloro-2-indolecarboxylate
Synonyms: 5-Cl-ICA-OEt;TIMTEC-BB SBB003329;2-CARBETHOXY-5-CHLOROINDOLE;5-CHLORO-2-INDOLECARBOXYLIC;Ethyl-5-chloro Anthranilate;5-CHLORO-INDOLE-2-ETHYL FORMATE;2-(ethoxycarbonyl)-5-chloro-indole;ETHYL 5-CHLORO-2-INDOLECARBOXYLATE;ETHYL 5-CHLOROINDOLE-2-CARBOXYLATE;ethyl 4-chloro-2-indolecarboxylate
CBNumber: CB5126082
Molecular Formula: C11H10ClNO2
Formula Weight: 223.66
MOL File: 4792-67-0.mol

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Ethyl 5-chloro-2-indolecarboxylate Property

Melting point:: 166-168 °C (lit.)
Boiling point:: 375.0±22.0 °C(Predicted)
Density: 1.2405 (rough estimate)
refractive index: 1.5500 (estimate)
storage temp.: Sealed in dry,Room Temperature
form: Powder or Crystals
pka: 14.10±0.30(Predicted)
color: Yellow to orange to tan or light brown
BRN: 170255
InChI: InChI=1S/C11H10ClNO2/c1-2-15-11(14)10-6-7-5-8(12)3-4-9(7)13-10/h3-6,13H,2H2,1H3
InChIKey: LWKIFKYHCJAIAB-UHFFFAOYSA-N
SMILES: N1C2=C(C=C(Cl)C=C2)C=C1C(OCC)=O
CAS DataBase Reference: 4792-67-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-37-26
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 138096
Product name: Ethyl 5-chloro-2-indolecarboxylate
Purity: 97%
Packaging: 10g
Price: $187
Updated: 2025/07/31

TCI Chemical

Product number: E0696
Product name: Ethyl 5-Chloroindole-2-carboxylate
Purity: >98.0%(GC)
Packaging: 5g
Price: $86
Updated: 2025/07/31

TCI Chemical

Product number: E0696
Product name: Ethyl 5-Chloroindole-2-carboxylate
Purity: >98.0%(GC)
Packaging: 25g
Price: $296
Updated: 2025/07/31

TRC

Product number: C367030
Product name: 5-Chloroindole-2-carboxylicAcidEthylEster
Packaging: 100g
Price: $965
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0024813
Product name: 5-CHLOROINDOLE-2-CARBOXYLIC ACID ETHYL ESTER
Purity: 95.00%
Packaging: 25G
Price: $1432.43
Updated: 2021/12/16

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Ethyl 5-chloro-2-indolecarboxylate Chemical Properties,Usage,Production

Chemical Properties

yellowish to light brown crystalline powder

Uses

Ethyl 5-chloro-2-indolecarboxylate was used in the synthesis of anti-allergic agents.

Uses

5-Chloroindole-2-carboxylic acid ethyl ester is a used in the synthetic preparation of a potent anticonvulsant Ethyl 4-methylamino-5,7-dichloro-2-quinolinecarboxylate.

Synthesis

5296-86-6

4792-67-0

General procedure for the synthesis of ethyl 5-chloroindole-2-carboxylate from ethyl 2-[(4-chlorophenyl)hydrazinylidene]propionate: 500 g of polyphosphoric acid was mixed with 250 g of phosphoric acid and heated to 70 °C under stirring. 70 g of raw material 4-chlorophenylhydrazine pyruvic acid phenylhydrazone was added in batches, and the reaction temperature was controlled in the range of 70-90 °C. After 1 hour of reaction, it was confirmed that the feedstock was completely consumed. The reaction temperature was continued to be maintained for 40 minutes to ensure complete reaction. After completion of the reaction, the reaction mixture was poured into 1500 g of ice-water mixture and cooled to room temperature. The precipitate was collected by filtration and dried to give a light yellow solid product. Upon further drying, 58 g of ethyl 5-chloroindole-2-carboxylate was obtained in 90% yield.

References

[1] Patent: CN104402795, 2017, B. Location in patent: Paragraph 0045; 0047
[2] Journal of the Chemical Society, 1955, p. 3499,3502
[3] Journal of Medicinal Chemistry, 1988, vol. 31, # 5, p. 944 - 948
[4] Archiv der Pharmazie, 2008, vol. 341, # 5, p. 294 - 300
[5] Tetrahedron, 2016, vol. 72, # 22, p. 3014 - 3021

Ethyl 5-chloro-2-indolecarboxylate Preparation Products And Raw materials

Raw materials

4-Chlorophenylhydrazine hydrochloride Ethanol Ethyl pyruvate Polyphosphoric acid

Preparation Products

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Ethyl 5-chloro-2-indolecarboxylate Suppliers

Americas 1 Belgium 1 Canada 1 China 193 Europe 3 Germany 4 India 12 Japan 4 Russia 1 Slovakia 1 Switzerland 5 Ukraine 3 United Kingdom 13 United States 42 Global 284

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View Lastest Price from Ethyl 5-chloro-2-indolecarboxylate manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Ethyl 5-chloro-2-indolecarboxylate 4792-67-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

Shaanxi Dideu Medichem Co. Ltd

Product: Ethyl 5-chloro-2-indolecarboxylate 4792-67-0
Price: US $1.00-22.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100000KG
Release date: 2024-07-22

Chemwill Asia Co.,Ltd.

Product: Ethyl 5-chloro-2-indolecarboxylate in stock Factory 4792-67-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: TOP 3 Factory in China
Supply Ability: Top 3 largest production capacity Factory
Release date: 2019-04-03

4792-67-0, Ethyl 5-chloro-2-indolecarboxylateRelated Search:

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Ethyl 5-chloro-2-indolecarboxylate in stock Factory

5-CHLOROINDOLE-2-CARBOXYLIC ACID ETHYL ESTER

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5-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER

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2-(ethoxycarbonyl)-5-chloro-indole

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ETHYL 5-CHLOROINDOLE-2-CARBOXYLATE

5-CHLORO-2-INDOLECARBOXYLIC

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TIMTEC-BB SBB003329

ethyl 4-chloro-2-indolecarboxylate

1H-Indole-2-carboxylic acid, 5-chloro-, ethyl ester

Ethyl 5-chloro-2-indolecarboxylate ,97%

5-Cl-ICA-OEt

Ethyl5-Chloroindole-2-carboxylate&gt

Ethyl-5-chloro Anthranilate

4792-67-0

C11H10NO2Cl

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Building Blocks

C11

Pharmaceutical Intermediates

Halogenated Heterocycles

Heterocyclic Building Blocks

IndolesBuilding Blocks

Indoles

Simple Indoles

blocks

Carboxes

IndolesOxindoles

Aromatic Esters

Indole

Organic acids