ChemicalBook > CAS DataBase List > Ethyl 5-chloro-2-indolecarboxylate
Ethyl 5-chloro-2-indolecarboxylate
- Product Name
- Ethyl 5-chloro-2-indolecarboxylate
- CAS No.
- 4792-67-0
- Chemical Name
- Ethyl 5-chloro-2-indolecarboxylate
- Synonyms
- 5-Cl-ICA-OEt;TIMTEC-BB SBB003329;2-CARBETHOXY-5-CHLOROINDOLE;5-CHLORO-2-INDOLECARBOXYLIC;Ethyl-5-chloro Anthranilate;5-CHLORO-INDOLE-2-ETHYL FORMATE;2-(ethoxycarbonyl)-5-chloro-indole;ETHYL 5-CHLORO-2-INDOLECARBOXYLATE;ETHYL 5-CHLOROINDOLE-2-CARBOXYLATE;ethyl 4-chloro-2-indolecarboxylate
- CBNumber
- CB5126082
- Molecular Formula
- C11H10ClNO2
- Formula Weight
- 223.66
- MOL File
- 4792-67-0.mol
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Ethyl 5-chloro-2-indolecarboxylate Property
- Melting point:
- 166-168 °C (lit.)
- Boiling point:
- 375.0±22.0 °C(Predicted)
- Density
- 1.2405 (rough estimate)
- refractive index
- 1.5500 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- form
- Powder or Crystals
- pka
- 14.10±0.30(Predicted)
- color
- Yellow to orange to tan or light brown
- BRN
- 170255
- InChI
- InChI=1S/C11H10ClNO2/c1-2-15-11(14)10-6-7-5-8(12)3-4-9(7)13-10/h3-6,13H,2H2,1H3
- InChIKey
- LWKIFKYHCJAIAB-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(Cl)C=C2)C=C1C(OCC)=O
- CAS DataBase Reference
- 4792-67-0(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 24/25-37-26
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29339900
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 138096
- Product name
- Ethyl 5-chloro-2-indolecarboxylate
- Purity
- 97%
- Packaging
- 10g
- Price
- $187
- Updated
- 2025/07/31
TCI Chemical
- Product number
- E0696
- Product name
- Ethyl 5-Chloroindole-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $86
- Updated
- 2025/07/31
TCI Chemical
- Product number
- E0696
- Product name
- Ethyl 5-Chloroindole-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $296
- Updated
- 2025/07/31
TRC
- Product number
- C367030
- Product name
- 5-Chloroindole-2-carboxylicAcidEthylEster
- Packaging
- 100g
- Price
- $965
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0024813
- Product name
- 5-CHLOROINDOLE-2-CARBOXYLIC ACID ETHYL ESTER
- Purity
- 95.00%
- Packaging
- 25G
- Price
- $1432.43
- Updated
- 2021/12/16
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Ethyl 5-chloro-2-indolecarboxylate Chemical Properties,Usage,Production
Chemical Properties
yellowish to light brown crystalline powder
Uses
Ethyl 5-chloro-2-indolecarboxylate was used in the synthesis of anti-allergic agents.
Uses
5-Chloroindole-2-carboxylic acid ethyl ester is a used in the synthetic preparation of a potent anticonvulsant Ethyl 4-methylamino-5,7-dichloro-2-quinolinecarboxylate.
Synthesis
5296-86-6
4792-67-0
General procedure for the synthesis of ethyl 5-chloroindole-2-carboxylate from ethyl 2-[(4-chlorophenyl)hydrazinylidene]propionate: 500 g of polyphosphoric acid was mixed with 250 g of phosphoric acid and heated to 70 °C under stirring. 70 g of raw material 4-chlorophenylhydrazine pyruvic acid phenylhydrazone was added in batches, and the reaction temperature was controlled in the range of 70-90 °C. After 1 hour of reaction, it was confirmed that the feedstock was completely consumed. The reaction temperature was continued to be maintained for 40 minutes to ensure complete reaction. After completion of the reaction, the reaction mixture was poured into 1500 g of ice-water mixture and cooled to room temperature. The precipitate was collected by filtration and dried to give a light yellow solid product. Upon further drying, 58 g of ethyl 5-chloroindole-2-carboxylate was obtained in 90% yield.
References
[1] Patent: CN104402795, 2017, B. Location in patent: Paragraph 0045; 0047
[2] Journal of the Chemical Society, 1955, p. 3499,3502
[3] Journal of Medicinal Chemistry, 1988, vol. 31, # 5, p. 944 - 948
[4] Archiv der Pharmazie, 2008, vol. 341, # 5, p. 294 - 300
[5] Tetrahedron, 2016, vol. 72, # 22, p. 3014 - 3021
Ethyl 5-chloro-2-indolecarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 5-chloro-2-indolecarboxylate manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- Ethyl 5-chloro-2-indolecarboxylate 4792-67-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-19
Shaanxi Dideu Medichem Co. Ltd
- Product
- Ethyl 5-chloro-2-indolecarboxylate 4792-67-0
- Price
- US $1.00-22.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000KG
- Release date
- 2024-07-22
Chemwill Asia Co.,Ltd.
- Product
- Ethyl 5-chloro-2-indolecarboxylate in stock Factory 4792-67-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- TOP 3 Factory in China
- Supply Ability
- Top 3 largest production capacity Factory
- Release date
- 2019-04-03
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