5-Chloroindole-2-carboxylic acid

Product Name: 5-Chloroindole-2-carboxylic acid
CAS No.: 10517-21-2
Chemical Name: 5-Chloroindole-2-carboxylic acid
Synonyms: 5-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID;5-Cl-ICA;AKOS JY2083234;TIMTEC-BB SBB003591;5-CHLORO-2-INDOLECARBOXYLATE;5-chloroindole-2-carboxylate;5-CHLORO-2-INDOLECARBOXYLIC ACID;5-CHLOROINDOLE-2-CARBOXYLIC ACID;5-Chloroindole-2-CarboxylicAcid99%;5-chloro-1h-indole-2-carboxylicaci
CBNumber: CB5149913
Molecular Formula: C9H6ClNO2
Formula Weight: 195.6
MOL File: 10517-21-2.mol

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5-Chloroindole-2-carboxylic acid Property

Melting point:: 287 °C (dec.) (lit.)
Boiling point:: 449.7±25.0 °C(Predicted)
Density: 1.3228 (rough estimate)
refractive index: 1.5790 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 4.26±0.30(Predicted)
color: Beige
BRN: 153229
InChI: InChI=1S/C9H6ClNO2/c10-6-1-2-7-5(3-6)4-8(11-7)9(12)13/h1-4,11H,(H,12,13)
InChIKey: FUQOTYRCMBZFOL-UHFFFAOYSA-N
SMILES: N1C2=C(C=C(Cl)C=C2)C=C1C(O)=O
CAS DataBase Reference: 10517-21-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
RTECS: NL5998400
HazardClass: IRRITANT
HS Code: 29339990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C47809
Product name: 5-Chloroindole-2-carboxylic acid
Purity: 98%
Packaging: 1g
Price: $70.6
Updated: 2025/07/31

TCI Chemical

Product number: C1868
Product name: 5-Chloroindole-2-carboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $95
Updated: 2025/07/31

TCI Chemical

Product number: C1868
Product name: 5-Chloroindole-2-carboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $326
Updated: 2025/07/31

TRC

Product number: C377710
Product name: 5-Chloroindole-2-carboxylic acid
Packaging: 5g
Price: $150
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H21-5-68
Product name: 5-Chloroindole-2-carboxylic acid
Packaging: 5G
Price: $160
Updated: 2021/12/16

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5-Chloroindole-2-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

light pink to beige or light brown fine

Uses

NMDA receptor antagonist (gly)

Uses

5-Chloroindole-2-carboxylic Acid is used in the synthesis of 4-(3-aminomethylphenyl)piperidine-1-carboxamides as potent, selective, and orally bioavailable inhibitors of βII tryptase. It is also a reagent used to prepare indole amides with possible antihistaminic activities.

Definition

ChEBI: 5-chloro-1H-indole-2-carboxylic acid is an indolyl carboxylic acid.

Synthesis

4792-67-0

10517-21-2

The general procedure for the synthesis of 5-chloroindole-2-carboxylic acid from ethyl 5-chloroindole-2-carboxylate was as follows: 111.5 g of ethyl 5-chloroindole-2-carboxylate was dissolved in a mixture of 31.25 g of 96% sodium hydroxide, 183 ml of methanol, and 183 ml of water, and was heated and refluxed for 1 hour. After the reaction was completed, the reaction solution was cooled to 40 °C, and 10% hydrochloric acid was slowly added dropwise to adjust the pH to 3-4. After the reaction solution was completely cooled, the precipitate was collected by filtration to obtain 90.1 g of off-white 5-chloroindole-2-carboxylic acid in 92.5% yield, and the purity of the product was ≥96% by high performance liquid chromatography (HPLC).

References

[1] Chemical Biology and Drug Design, 2017, vol. 90, # 1, p. 64 - 82
[2] Patent: CN104402795, 2017, B. Location in patent: Paragraph 0045; 0048
[3] European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 3149 - 3157
[4] Advanced Synthesis and Catalysis, 2016, vol. 358, # 24, p. 3938 - 3942
[5] Journal of the Chemical Society, 1955, p. 3499,3502

5-Chloroindole-2-carboxylic acid Preparation Products And Raw materials

Raw materials

4-Chlorophenylhydrazine hydrochloride Ethanol Ethyl pyruvate Lithium hydroxide Polyphosphoric acid

Preparation Products

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5-Chloroindole-2-carboxylic acid Suppliers

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View Lastest Price from 5-Chloroindole-2-carboxylic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Chloroindole-2-carboxylic acid 10517-21-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

Chemwill Asia Co.,Ltd.

Product: 5-Chloroindole-2-carboxylic acid in stock Factory 10517-21-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: TOP 3 Factory in China
Supply Ability: Top 3 largest production capacity Factory
Release date: 2019-04-03

Career Henan Chemical Co

Product: 5-Chloroindole-2-carboxylic acid 10517-21-2
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-15

10517-21-2, 5-Chloroindole-2-carboxylic acidRelated Search:

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10517-21-2

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