ChemicalBook > CAS DataBase List > 5-Chloroindole-2-carboxylic acid
5-Chloroindole-2-carboxylic acid
- Product Name
- 5-Chloroindole-2-carboxylic acid
- CAS No.
- 10517-21-2
- Chemical Name
- 5-Chloroindole-2-carboxylic acid
- Synonyms
- 5-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID;5-Cl-ICA;AKOS JY2083234;TIMTEC-BB SBB003591;5-CHLORO-2-INDOLECARBOXYLATE;5-chloroindole-2-carboxylate;5-CHLORO-2-INDOLECARBOXYLIC ACID;5-CHLOROINDOLE-2-CARBOXYLIC ACID;5-Chloroindole-2-CarboxylicAcid99%;5-chloro-1h-indole-2-carboxylicaci
- CBNumber
- CB5149913
- Molecular Formula
- C9H6ClNO2
- Formula Weight
- 195.6
- MOL File
- 10517-21-2.mol
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5-Chloroindole-2-carboxylic acid Property
- Melting point:
- 287 °C (dec.) (lit.)
- Boiling point:
- 449.7±25.0 °C(Predicted)
- Density
- 1.3228 (rough estimate)
- refractive index
- 1.5790 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.26±0.30(Predicted)
- color
- Beige
- BRN
- 153229
- InChI
- InChI=1S/C9H6ClNO2/c10-6-1-2-7-5(3-6)4-8(11-7)9(12)13/h1-4,11H,(H,12,13)
- InChIKey
- FUQOTYRCMBZFOL-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(Cl)C=C2)C=C1C(O)=O
- CAS DataBase Reference
- 10517-21-2(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- RTECS
- NL5998400
- HazardClass
- IRRITANT
- HS Code
- 29339990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- C47809
- Product name
- 5-Chloroindole-2-carboxylic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $70.6
- Updated
- 2025/07/31
TCI Chemical
- Product number
- C1868
- Product name
- 5-Chloroindole-2-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $95
- Updated
- 2025/07/31
TCI Chemical
- Product number
- C1868
- Product name
- 5-Chloroindole-2-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $326
- Updated
- 2025/07/31
TRC
- Product number
- C377710
- Product name
- 5-Chloroindole-2-carboxylic acid
- Packaging
- 5g
- Price
- $150
- Updated
- 2021/12/16
BroadPharm
- Product number
- BP-11766
- Product name
- 5-chloro-1H-indole-2-carboxylicacid
- Packaging
- 1g
- Price
- $22
- Updated
- 2021/12/16
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5-Chloroindole-2-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
light pink to beige or light brown fine
Uses
NMDA receptor antagonist (gly)
Uses
5-Chloroindole-2-carboxylic Acid is used in the synthesis of 4-(3-aminomethylphenyl)piperidine-1-carboxamides as potent, selective, and orally bioavailable inhibitors of βII tryptase. It is also a reagent used to prepare indole amides with possible antihistaminic activities.
Definition
ChEBI: 5-chloro-1H-indole-2-carboxylic acid is an indolyl carboxylic acid.
Synthesis
4792-67-0
10517-21-2
The general procedure for the synthesis of 5-chloroindole-2-carboxylic acid from ethyl 5-chloroindole-2-carboxylate was as follows: 111.5 g of ethyl 5-chloroindole-2-carboxylate was dissolved in a mixture of 31.25 g of 96% sodium hydroxide, 183 ml of methanol, and 183 ml of water, and was heated and refluxed for 1 hour. After the reaction was completed, the reaction solution was cooled to 40 °C, and 10% hydrochloric acid was slowly added dropwise to adjust the pH to 3-4. After the reaction solution was completely cooled, the precipitate was collected by filtration to obtain 90.1 g of off-white 5-chloroindole-2-carboxylic acid in 92.5% yield, and the purity of the product was ≥96% by high performance liquid chromatography (HPLC).
References
[1] Chemical Biology and Drug Design, 2017, vol. 90, # 1, p. 64 - 82
[2] Patent: CN104402795, 2017, B. Location in patent: Paragraph 0045; 0048
[3] European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 3149 - 3157
[4] Advanced Synthesis and Catalysis, 2016, vol. 358, # 24, p. 3938 - 3942
[5] Journal of the Chemical Society, 1955, p. 3499,3502
5-Chloroindole-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Chloroindole-2-carboxylic acid manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- 5-Chloroindole-2-carboxylic acid 10517-21-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-19
Chemwill Asia Co.,Ltd.
- Product
- 5-Chloroindole-2-carboxylic acid in stock Factory 10517-21-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- TOP 3 Factory in China
- Supply Ability
- Top 3 largest production capacity Factory
- Release date
- 2019-04-03
Career Henan Chemical Co
- Product
- 5-Chloroindole-2-carboxylic acid 10517-21-2
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-15
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