5-Chloroindole-3-carboxylic acid
- Product Name
- 5-Chloroindole-3-carboxylic acid
- CAS No.
- 10406-05-0
- Chemical Name
- 5-Chloroindole-3-carboxylic acid
- Synonyms
- RARECHEM AL BE 0763;5-chloro-3-indole acid;5-chloro-3-Indolecarboxylicacid;5-CHLOROINDOLE-3-CARBOXYLIC ACID;5-Chloro-1H-indol-3-carboxylic acid;5-CHLORO-1H-INDOLE-3-CARBOXYLIC ACID;1H-Indole-3-carboxylic acid, 5-chloro-;5-Chloro-1H-indole-3-carboxylic acid, CAS 10406-05-0
- CBNumber
- CB8415732
- Molecular Formula
- C9H6ClNO2
- Formula Weight
- 195.6
- MOL File
- 10406-05-0.mol
5-Chloroindole-3-carboxylic acid Property
- Melting point:
- 234-235 °C
- Boiling point:
- 449.7±25.0 °C(Predicted)
- Density
- 1.548±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.69±0.30(Predicted)
- Appearance
- Off-white to brown Solid
- InChI
- InChI=1S/C9H6ClNO2/c10-5-1-2-8-6(3-5)7(4-11-8)9(12)13/h1-4,11H,(H,12,13)
- InChIKey
- XUDITEOFEQOSAK-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(Cl)C=C2)C(C(O)=O)=C1
- CAS DataBase Reference
- 10406-05-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C380783
- Product name
- 5-Chloroindole-3-carboxylicacid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- C380783
- Product name
- 5-Chloroindole-3-carboxylicacid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- X8690
- Product name
- 5-Chloroindole-3-carboxylicacid
- Packaging
- 5g
- Price
- $232
- Updated
- 2021/12/16
- Product number
- FC56780
- Product name
- 5-Chloroindole-3-Carboxylic Acid
- Packaging
- 2g
- Price
- $237.9
- Updated
- 2021/12/16
- Product number
- FC56780
- Product name
- 5-Chloroindole-3-Carboxylic Acid
- Packaging
- 1g
- Price
- $148.7
- Updated
- 2021/12/16
5-Chloroindole-3-carboxylic acid Chemical Properties,Usage,Production
Uses
5-Chloroindole-3-carboxylic acid is a pharmaceutical intermediate compound that can be used in the preparation of compounds and compositions for the treatment of disorders associated with sting activity.
Synthesis
17422-32-1
407-25-0
10406-05-0
5.0 g (33.0 mmol) of commercially available 5-chloro-1H-indole was dissolved in 50 mL of anhydrous N,N-dimethylformamide (DMF) and the reaction system was kept at 0°C. Slowly 7.35 g (35.0 mmol) of trifluoroacetic anhydride was added dropwise to the above solution. After the dropwise addition, the reaction mixture was stirred at room temperature for 3 hours. After completion of the reaction, the mixture was slowly poured into 200 mL of ice water and the precipitate was collected by filtration. The resulting precipitate was suspended in 200 mL of 20% sodium hydroxide (NaOH) aqueous solution and heated at reflux overnight. After cooling, the aqueous phase was extracted twice with dichloromethane (100 mL each time). The organic phases were combined and the aqueous phase was acidified to pH 2-3 with concentrated hydrochloric acid to precipitate a solid. The crystalline product was collected by filtration and washed with a small amount of cold water. Finally, the product was dried in a vacuum drying oven to give 6.0 g of 5-chloroindole-3-carboxylic acid in 93% yield.
References
[1] Patent: US2004/9976, 2004, A1. Location in patent: Page/Page column 52
[2] Patent: EP1266897, 2002, A2. Location in patent: Page 74
[3] Patent: US6410562, 2002, B1
5-Chloroindole-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Chloroindole-3-carboxylic acid manufacturers
- Product
- 5-Chloroindole-3-carboxylic acid 10406-05-0
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08