ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE
- Product Name
- ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE
- CAS No.
- 37033-95-7
- Chemical Name
- ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE
- Synonyms
- ETHYL 5-(BENZYLOXY)-1H-INDOLE-2-CARBOXYLATE;NSC 30931;5-BzlO-ICA-OEt;BUTTPARK 97\57-93;5-BENZYLOXY-2-CARBETHOXYINDOLE;ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE;5-BENZYLOXYINDOLE ETHYL-2-CARBOXYLATE;5-BENZYLOXYINDOLE ETHYL-2-CARBOXYLATE 97%;5-(Benzyloxy)-2-(ethoxycarbonyl)-1H-indole;BENZYLOXY INDOLECARBOXYLIC ACID ETHYL ESTER
- CBNumber
- CB1394423
- Molecular Formula
- C18H17NO3
- Formula Weight
- 295.33
- MOL File
- 37033-95-7.mol
ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE Property
- Melting point:
- 163 °C
- Boiling point:
- 481.4±30.0 °C(Predicted)
- Density
- 1.225±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- form
- powder
- pka
- 14+-.0.30(Predicted)
- Appearance
- Off-white to light brown Solid
- BRN
- 281129
- InChI
- InChI=1S/C18H17NO3/c1-2-21-18(20)17-11-14-10-15(8-9-16(14)19-17)22-12-13-6-4-3-5-7-13/h3-11,19H,2,12H2,1H3
- InChIKey
- DCIFXYFKVKDOLL-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(OCC3=CC=CC=C3)C=C2)C=C1C(OCC)=O
- CAS DataBase Reference
- 37033-95-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B125013
- Product name
- Ethyl5-(Benzyloxy)-1H-indole-2-carboxylate
- Packaging
- 2.5g
- Price
- $265
- Updated
- 2021/12/16
- Product number
- CHM0029757
- Product name
- ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $630
- Updated
- 2021/12/16
- Product number
- CHM0029757
- Product name
- ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1050
- Updated
- 2021/12/16
- Product number
- CHM0029757
- Product name
- ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 12G
- Price
- $1104.08
- Updated
- 2021/12/16
- Product number
- W5816
- Product name
- Ethyl5-(benzyloxy)-1H-indole-2-carboxylate
- Packaging
- 5g
- Price
- $258
- Updated
- 2021/12/16
ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE Chemical Properties,Usage,Production
Uses
Reactant for preparation of indolyl ethanones as indoleamine 2,3-dioxygenase inhibitors 1 Reactant for preparation of histamine H3 receptor inverse agonists 2 Reactant for preparation of PPAR-γ binding agents with potential application to the treatment of osteoporosis 3 Reactant for preparation of Nonpeptide glycoprotein IIB/IIIA inhibitors 4
Synthesis
1.1) 80 ml of sulfuric acid was dissolved in 450 mL of ethanol and cooled to 0C;
1.2) 359 mmol (90 g) of 4-benzyloxyphenylhydrazine hydrochloride was added to the mixture of 1.1) to form a suspension;
1.3) 43.9 mL of ethyl pyruvate was added to 90 mL of anhydrous ethanol;
1.4) the suspension of step 1.2) was added to step 1.3), magnetically stirred for 2h, warmed up to 45C, and held to react for 16h;
1.5) the solution of step 1.4) was cooled to room temperature, 200mL of ethanol was added, filtered, and the solids were washed with ethanol, cyclohexane, and water in turn, dried, and yielded compound 3, i.e., 5-benzyloxyindole-2-carboxylic acid ethyl ester, in 72% yield ( 76.3g).
ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE manufacturers
- Product
- ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE 37033-95-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 97%+
- Supply Ability
- as request
- Release date
- 2018-12-24