ChemicalBook > CAS DataBase List > HDH-PHARMA 26173

HDH-PHARMA 26173

Product Name
HDH-PHARMA 26173
CAS No.
871836-51-0
Chemical Name
HDH-PHARMA 26173
Synonyms
4-CHLORO-1H-PYRAZOLO[4,3-C]PYRIDINE;1H-Pyrazolo[4,3-c]pyridine,4-chloro-;100182;EOS-61542;HDH-PHARMA 26173;4-chloro-1H-pyrazolo[4;4-Chloro-1H-pyrazolo[4,3-...;4-chloro-1H-pyrazolo[4,4-c]pyridine;4-Chloro-1H-pyrazolo[4,3-c]pyridine 98%;4-chloro-1H-pyrazolo[4,3-c]pyridin-6-aMine
CBNumber
CB92465688
Molecular Formula
C6H4ClN3
Formula Weight
153.57
MOL File
871836-51-0.mol
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HDH-PHARMA 26173 Property

Boiling point:
357.5±22.0 °C(Predicted)
Density 
1.531
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
solid
pka
10.46±0.40(Predicted)
Appearance
White to light yellow Solid
InChI
InChI=1S/C6H4ClN3/c7-6-4-3-9-10-5(4)1-2-8-6/h1-3H,(H,9,10)
InChIKey
FUXZQGSDRGDYGX-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC2NN=CC1=2
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BLN00015
Product name
4-Chloro-1H-pyrazolo[4,3-c]pyridine
Packaging
1g
Price
$1090
Updated
2025/07/31
TRC
Product number
C379330
Product name
4-Chloro-1H-pyrazolo[4,3-c]pyridine
Packaging
1g
Price
$165
Updated
2021/12/16
Matrix Scientific
Product number
067147
Product name
4-Chloro-1H-pyrazolo[4,3-c]pyridine
Packaging
1g
Price
$30
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-5-41
Product name
4-Chloro-1H-pyrazolo[4,3-c]pyridine
Purity
95%
Packaging
1g
Price
$75
Updated
2021/12/16
AK Scientific
Product number
W8946
Product name
4-Chloro-1H-pyrazolo[4,3-c]pyridine
Packaging
1g
Price
$82
Updated
2021/12/16
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HDH-PHARMA 26173 Chemical Properties,Usage,Production

Uses

4-Chloro-1H-pyrazolo[4,3-c]pyridine is used to prepare gp120-?CD4 inhibitors.

Synthesis

134031-24-6

871836-51-0

General procedure for the synthesis of 4-chloro-1H-pyrazolo[4,3-c]pyridine using 2,4-dichloronicotinaldehyde as starting material: intermediate 1 (1.7 g, 9.7 mmol) was dissolved in dimethoxyethane (12 ml) at room temperature, followed by addition of hydrazine monohydrate (1.2 ml, 38.6 mmol). The reaction mixture was stirred at 75°C overnight. Upon completion of the reaction, the mixture was concentrated to dryness and the resulting crude product was purified by fast chromatography using 20% to 100% ethyl acetate/petroleum ether gradient elution to afford the target product, 4-chloro-1H-pyrazolo[4,3-c]pyridine, as a white solid (0.82 g, 56% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 7.60 (d, J = 6.9 Hz, 1H), 8.14 (d, J = 6.0 Hz, 1H), 8.32 (s, 1H); mass spectra (ES + APCI)+: m/z 154 [M + H]+.

References

[1] Patent: WO2012/38743, 2012, A1. Location in patent: Page/Page column 82
[2] Patent: WO2010/106333, 2010, A1. Location in patent: Page/Page column 78-79
[3] Patent: WO2016/37578, 2016, A1. Location in patent: Page/Page column 118
[4] Patent: EP2857400, 2015, A1. Location in patent: Paragraph 1032
[5] Patent: WO2015/58084, 2015, A1. Location in patent: Paragraph 0403

HDH-PHARMA 26173 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from HDH-PHARMA 26173 manufacturers

Career Henan Chemical Co
Product
HDH-PHARMA 26173 871836-51-0
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200kg
Release date
2018-12-21

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