HDH-PHARMA 26173
- Product Name
- HDH-PHARMA 26173
- CAS No.
- 871836-51-0
- Chemical Name
- HDH-PHARMA 26173
- Synonyms
- 4-CHLORO-1H-PYRAZOLO[4,3-C]PYRIDINE;1H-Pyrazolo[4,3-c]pyridine,4-chloro-;100182;EOS-61542;HDH-PHARMA 26173;4-chloro-1H-pyrazolo[4;4-Chloro-1H-pyrazolo[4,3-...;4-chloro-1H-pyrazolo[4,4-c]pyridine;4-Chloro-1H-pyrazolo[4,3-c]pyridine 98%;4-chloro-1H-pyrazolo[4,3-c]pyridin-6-aMine
- CBNumber
- CB92465688
- Molecular Formula
- C6H4ClN3
- Formula Weight
- 153.57
- MOL File
- 871836-51-0.mol
HDH-PHARMA 26173 Property
- Boiling point:
- 357.5±22.0 °C(Predicted)
- Density
- 1.531
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- pka
- 10.46±0.40(Predicted)
- Appearance
- White to light yellow Solid
- InChI
- InChI=1S/C6H4ClN3/c7-6-4-3-9-10-5(4)1-2-8-6/h1-3H,(H,9,10)
- InChIKey
- FUXZQGSDRGDYGX-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC2NN=CC1=2
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BLN00015
- Product name
- 4-Chloro-1H-pyrazolo[4,3-c]pyridine
- Packaging
- 1g
- Price
- $1090
- Updated
- 2025/07/31
- Product number
- C379330
- Product name
- 4-Chloro-1H-pyrazolo[4,3-c]pyridine
- Packaging
- 1g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 067147
- Product name
- 4-Chloro-1H-pyrazolo[4,3-c]pyridine
- Packaging
- 1g
- Price
- $30
- Updated
- 2021/12/16
- Product number
- 3H32-5-41
- Product name
- 4-Chloro-1H-pyrazolo[4,3-c]pyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- W8946
- Product name
- 4-Chloro-1H-pyrazolo[4,3-c]pyridine
- Packaging
- 1g
- Price
- $82
- Updated
- 2021/12/16
HDH-PHARMA 26173 Chemical Properties,Usage,Production
Uses
4-Chloro-1H-pyrazolo[4,3-c]pyridine is used to prepare gp120-?CD4 inhibitors.
Synthesis
134031-24-6
871836-51-0
General procedure for the synthesis of 4-chloro-1H-pyrazolo[4,3-c]pyridine using 2,4-dichloronicotinaldehyde as starting material: intermediate 1 (1.7 g, 9.7 mmol) was dissolved in dimethoxyethane (12 ml) at room temperature, followed by addition of hydrazine monohydrate (1.2 ml, 38.6 mmol). The reaction mixture was stirred at 75°C overnight. Upon completion of the reaction, the mixture was concentrated to dryness and the resulting crude product was purified by fast chromatography using 20% to 100% ethyl acetate/petroleum ether gradient elution to afford the target product, 4-chloro-1H-pyrazolo[4,3-c]pyridine, as a white solid (0.82 g, 56% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 7.60 (d, J = 6.9 Hz, 1H), 8.14 (d, J = 6.0 Hz, 1H), 8.32 (s, 1H); mass spectra (ES + APCI)+: m/z 154 [M + H]+.
References
[1] Patent: WO2012/38743, 2012, A1. Location in patent: Page/Page column 82
[2] Patent: WO2010/106333, 2010, A1. Location in patent: Page/Page column 78-79
[3] Patent: WO2016/37578, 2016, A1. Location in patent: Page/Page column 118
[4] Patent: EP2857400, 2015, A1. Location in patent: Paragraph 1032
[5] Patent: WO2015/58084, 2015, A1. Location in patent: Paragraph 0403
HDH-PHARMA 26173 Preparation Products And Raw materials
Raw materials
Preparation Products
HDH-PHARMA 26173 Suppliers
- Tel
- --
- Fax
- --
- Country
- India
- ProdList
- 206
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from HDH-PHARMA 26173 manufacturers
- Product
- HDH-PHARMA 26173 871836-51-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-21