3-BROMO-7-METHOXYQUINOLINE
- Product Name
- 3-BROMO-7-METHOXYQUINOLINE
- CAS No.
- 959121-99-4
- Chemical Name
- 3-BROMO-7-METHOXYQUINOLINE
- Synonyms
- PO-2009050602-P-068;3-BROMO-7-METHOXYQUINOLINE;Quinoline, 3-bromo-7-methoxy-;2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethyl (4-nitrophenyl) carbonate
- CBNumber
- CB92467349
- Molecular Formula
- C10H8BrNO
- Formula Weight
- 238.08
- MOL File
- 959121-99-4.mol
3-BROMO-7-METHOXYQUINOLINE Property
- Boiling point:
- 318.3±22.0 °C(Predicted)
- Density
- 1.516±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 2.85±0.25(Predicted)
- Appearance
- Off-white to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- HCH0364653
- Product name
- 3-BROMO-7-METHOXYQUINOLINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.19
- Updated
- 2021/12/16
- Product number
- 6577AC
- Product name
- 3-Bromo-7-methoxyquinoline
- Packaging
- 1g
- Price
- $978
- Updated
- 2021/12/16
- Product number
- HCH0364653
- Product name
- 3-BROMO-7-METHOXYQUINOLINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1068.9
- Updated
- 2021/12/16
- Product number
- 959121994
- Product name
- 3-Bromo-7-methoxyquinoline
- Packaging
- 100mg
- Price
- $170
- Updated
- 2021/12/16
- Product number
- CD11002891
- Product name
- 3-Bromo-7-methoxyquinoline
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $175
- Updated
- 2021/12/16
3-BROMO-7-METHOXYQUINOLINE Chemical Properties,Usage,Production
Synthesis
2065-75-0
536-90-3
959121-99-4
To synthesize 3-bromo-7-methoxyquinoline, 1.80 g (12.3 mmol, 1.1 eq.) of 2-bromomalonaldehyde was first dissolved in 30 mL of ethanol, followed by the addition of 1.25 mL of m-aminoanisole. The reaction mixture was stirred overnight at room temperature, then 20 mL of acetic acid was added and stirring was continued at 100 °C for 10 days. Upon completion of the reaction, the solvent was removed under vacuum using a rotary evaporator. The residual solid was partitioned between water and ethyl acetate. The aqueous phase was adjusted to alkaline with aqueous ammonia solution and the insoluble solid was filtered out. The filtrate was extracted with ethyl acetate, the organic phases were combined and dried with anhydrous magnesium sulfate. After filtration, the organic solvent was removed by rotary evaporator under vacuum. The crude product was purified by column chromatography using hexane/ethyl acetate (8:2, v/v) as eluent, resulting in 700 mg of the target product in 20% yield. The product characterization data were as follows: molecular formula C10H8BrNO; molecular weight 237/239; 1H-NMR (CDCl3) δ 8.76 (d, J = 2.2 Hz, 1H), 8.15 (d, J = 2.2 Hz, 1H), 7.55 (d, J = 9.1 Hz, 1H), 7.32 (d, J = 2.5 Hz, 1H), 7.15 (dd , J = 2.5 Hz, J = 8.8 Hz, 1H), 3.88 (s, 3H, OMe); 13C-NMR (CDCl3) δ 159.9, 150.4, 147.1, 135.9, 126.9, 123.4, 119.9, 113.6, 106.3, 54.6; IR (cm-1 ): 2961, 1620, 1581, 1491, 1462 1581, 1491, 1462, 1417, 1261, 1027, 796; MS (ESI): m/z 238-240 (M + H)+.
References
[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 7, p. 2158 - 2169
[2] Patent: US2010/204234, 2010, A1. Location in patent: Page/Page column 12
[3] Patent: WO2012/83165, 2012, A1. Location in patent: Page/Page column 98
3-BROMO-7-METHOXYQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-BROMO-7-METHOXYQUINOLINE manufacturers
- Product
- 3-BROMO-7-METHOXYQUINOLINE 959121-99-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-12-18