6H-DIBENZ[B,D]AZEPIN-6-ONE, 5,7-DIHYDRO-5-METHYL-
- Product Name
- 6H-DIBENZ[B,D]AZEPIN-6-ONE, 5,7-DIHYDRO-5-METHYL-
- CAS No.
- 209984-30-5
- Chemical Name
- 6H-DIBENZ[B,D]AZEPIN-6-ONE, 5,7-DIHYDRO-5-METHYL-
- Synonyms
- 5-Methyl-5H-dibenzo[b,d]azepin-6(7H);5-methyl-7H-benzo[d][1]benzazepin-6-one;N-methyl-5H-dibenzo[b,d]azepin-6(7H)-one;5,7-Dihydro-5-methyl-6H-dibenz[b,d]azepin-6-one;5-methyl-5,7-dihydro-6H-dibenzo[b,d]azepin-6-one;6H-DIBENZ[B,D]AZEPIN-6-ONE, 5,7-DIHYDRO-5-METHYL-;8-methyl-8-azatricyclo[9.4.0.0^{2,7}]pentadeca-1(15),2(7),3,5,11,13-hexaen-9-one;5-methyl-5H-dibenzo[b,d]azepin-6(7H)-one 5,7-Dihydro-5-methyl-6H-dibenz[b,d]azepin-6-one
- CBNumber
- CB92467884
- Molecular Formula
- C15H13NO
- Formula Weight
- 223.27
- MOL File
- 209984-30-5.mol
6H-DIBENZ[B,D]AZEPIN-6-ONE, 5,7-DIHYDRO-5-METHYL- Property
- Melting point:
- 155-160℃
- Boiling point:
- 474.1±24.0 °C(Predicted)
- Density
- 1.166
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Dichloromethane, Methanol
- form
- Solid
- pka
- 0.49±0.20(Predicted)
- color
- Off-White to Pale Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D449335
- Product name
- 5,7-Dihydro-5-methyl-6H-dibenz[b,d]azepin-6-one
- Packaging
- 50mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- FD22006
- Product name
- 5,7-Dihydro-5-methyl-6H-dibenz[b,d]azepin-6-one
- Packaging
- 10mg
- Price
- $139.8
- Updated
- 2021/12/16
- Product number
- FD22006
- Product name
- 5,7-Dihydro-5-methyl-6H-dibenz[b,d]azepin-6-one
- Packaging
- 50mg
- Price
- $462
- Updated
- 2021/12/16
- Product number
- CHM0292341
- Product name
- 5-METHYL-5H-DIBENZO[B,D]AZEPIN-6(7H)-ONE
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $739.2
- Updated
- 2021/12/16
- Product number
- FD22006
- Product name
- 5,7-Dihydro-5-methyl-6H-dibenz[b,d]azepin-6-one
- Packaging
- 100mg
- Price
- $840
- Updated
- 2021/12/16
6H-DIBENZ[B,D]AZEPIN-6-ONE, 5,7-DIHYDRO-5-METHYL- Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
An intermediate in the production of γ-secretase inhibitors.
Synthesis
20011-90-9
74-88-4
209984-30-5
Step A - Synthesis of 7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one: Sodium hydride (0.295 g, 7.46 mmol) and 9.0 mL of anhydrous DMF were added to a dry round-bottomed flask, and stirred until completely dissolved. Subsequently, 5,7-dihydro-6H-dibenzo[b,d]azepin-6-one (1.3 g, 6.22 mmol) was added, and the reaction mixture was stirred at 60 °C for 1 hour. Then, iodomethane (1.16 mL, 18.6 mmol) was slowly added dropwise and stirring was continued for 17 h under light protection. After completion of the reaction, the mixture was cooled to room temperature, diluted with a mixture of dichloromethane and water, washed sequentially with NaHSO4 solution and water, and the organic phase was dried with anhydrous Na2SO4. After concentration under reduced pressure, it was purified by fast column chromatography (silica gel, chloroform as eluent) to afford 0.885 g (63% yield) of the target compound, 5-methyl-5H-dibenz[b,d]azepin-6(7H)-one, as a colorless solid. Nuclear Magnetic Resonance Hydrogen Spectroscopy (1H-NMR, CDCl3) data: δ= 7.62 (d, 2H), 7.26-7.47 (m, 6H), 3.51 (m, 2H), 3.32 (s, 3H). Elemental analysis: C15H13NO (molecular weight = 223.27); mass spectrum (MH+) 223. calculated values: C, 80.69; H, 5.87; N, 6.27. measured values: C, 80.11; H, 5.95; N, 6.23.
References
[1] Organic Letters, 2008, vol. 10, # 21, p. 4871 - 4874
[2] Journal of Organic Chemistry, 2010, vol. 75, # 17, p. 5984 - 5993
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 22, p. 6392 - 6395
[4] Patent: EP951466, 2009, B1. Location in patent: Page/Page column 72
[5] Patent: US6958330, 2005, B1. Location in patent: Page/Page column 38-39
6H-DIBENZ[B,D]AZEPIN-6-ONE, 5,7-DIHYDRO-5-METHYL- Preparation Products And Raw materials
Raw materials
Preparation Products
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