2-(1'-(TERT-BUTOXYCARBONYL)SPIRO[CHROMAN-2,4'-PIPERIDINE]-4-YL)ACETIC ACID

Product Name: 2-(1'-(TERT-BUTOXYCARBONYL)SPIRO[CHROMAN-2,4'-PIPERIDINE]-4-YL)ACETIC ACID
CAS No.: 952681-82-2
Chemical Name: 2-(1'-(TERT-BUTOXYCARBONYL)SPIRO[CHROMAN-2,4'-PIPERIDINE]-4-YL)ACETIC ACID
Synonyms: Reaxys ID: 15583751;spiro[chroman-2,4'-piperidine]-4-yl);2-(1'-tert-butoxycarbonylspiro[chromane-2,4'-piperidine]-4-yl)acetic acid;2-(1'-(tert-Butoxycarbonyl)spiro[chroman-2,4'-piperidine]-4-yl)acetic acid;2-(1'-(tert-Butoxycarbonyl)spiro[chroman-2,4'-piperidine]-4-yl)acetic acid;2-[1'-[(2-Methylpropan-2-yl)oxycarbonyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-4-yl]acetic acid;Spiro[2H-1-benzopyran-2,4'-piperidine]-4-acetic acid, 1'-[(1,1-diMethylethoxy)carbonyl]-3,4-dihydro-
CBNumber: CB92468821
Molecular Formula: C20H27NO5
Formula Weight: 361.43
MOL File: 952681-82-2.mol

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2-(1'-(TERT-BUTOXYCARBONYL)SPIRO[CHROMAN-2,4'-PIPERIDINE]-4-YL)ACETIC ACID Property

Boiling point:: 516.4±50.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 4.54±0.10(Predicted)

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 074548
Product name: 2-(1'-(tert-Butoxycarbonyl)spiro[chroman-2,4'-piperidine]-4-yl)acetic acid
Purity: 95+%
Packaging: 250mg
Price: $693
Updated: 2021/12/16

AK Scientific

Product number: W9732
Product name: 2-(1'-(tert-Butoxycarbonyl)spiro[chroman-2,4'-piperidine]-4-yl)aceticacid
Packaging: 1g
Price: $709
Updated: 2021/12/16

Matrix Scientific

Product number: 074548
Product name: 2-(1'-(tert-Butoxycarbonyl)spiro[chroman-2,4'-piperidine]-4-yl)acetic acid
Purity: 95+%
Packaging: 1g
Price: $1498
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0125163
Product name: 2-(1'-(TERT-BUTOXYCARBONYL)SPIRO(CHROMAN-2,4'-PIPERIDINE)-4-YL)ACETIC ACID
Purity: 95.00%
Packaging: 1G
Price: $1566.18
Updated: 2021/12/16

AK Scientific

Product number: W9732
Product name: 2-(1'-(tert-Butoxycarbonyl)spiro[chroman-2,4'-piperidine]-4-yl)aceticacid
Packaging: 100mg
Price: $215
Updated: 2021/12/16

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2-(1'-(TERT-BUTOXYCARBONYL)SPIRO[CHROMAN-2,4'-PIPERIDINE]-4-YL)ACETIC ACID Chemical Properties,Usage,Production

Synthesis

952681-81-1

952681-82-2

Preparation of 5.7: Tert-butyl 4-(2-ethoxy-2-oxoethyl)spiro[chromane-2,4'-piperidine]-1'-carboxylate (5.6, 2.0 g, 5.1 mmol) was dissolved in a solvent mixture of methanol (30 mL), tetrahydrofuran (30 mL) and water (30 mL). To this solution was added lithium hydroxide monohydrate (1.35 g, 32 mmol). The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the mixture was concentrated under vacuum to remove the organic solvent. The aqueous phase was washed with ether to remove non-polar impurities. Subsequently, the aqueous layer was acidified with 1N HCl to pH about 4 and extracted with dichloromethane. The organic extracts were combined, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to afford the target product 2-(1'-(tert-butoxycarbonyl)spiro[chroman-2,4'-piperidin]-4-yl)acetic acid (5.7). Yield: 100%. 1H NMR (400 MHz, DMSO-d6) δ: 7.26 (m, 1H), 7.10 (m, 1H), 6.86 (m, 1H), 6.90 (m, 1H), 3.75 (m, 1H), 3.63 (m, 1H), 3.22 (m, 2H), 2.93 (m, 2H), 2.32 (dd, 1H) , 2.0 (m, 1H), 2.68-2.52 (m, 4H), 1.40 (s + m, 10H).

References

[1] Patent: WO2007/118151, 2007, A2. Location in patent: Page/Page column 60; 89; 90

2-(1'-(TERT-BUTOXYCARBONYL)SPIRO[CHROMAN-2,4'-PIPERIDINE]-4-YL)ACETIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(1'-(TERT-BUTOXYCARBONYL)SPIRO[CHROMAN-2,4'-PIPERIDINE]-4-YL)ACETIC ACID Suppliers

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952681-82-2, 2-(1'-(TERT-BUTOXYCARBONYL)SPIRO[CHROMAN-2,4'-PIPERIDINE]-4-YL)ACETIC ACIDRelated Search:

spiro[chroman-2,4'-piperidine]-4-yl)

Spiro[2H-1-benzopyran-2,4'-piperidine]-4-acetic acid, 1'-[(1,1-diMethylethoxy)carbonyl]-3,4-dihydro-

Reaxys ID: 15583751

2-(1'-tert-butoxycarbonylspiro[chromane-2,4'-piperidine]-4-yl)acetic acid

2-[1'-[(2-Methylpropan-2-yl)oxycarbonyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-4-yl]acetic acid

2-(1'-(tert-Butoxycarbonyl)spiro[chroman-2,4'-piperidine]-4-yl)acetic acid

952681-82-2