Acetyl-trans-resveratrol
- Product Name
- Acetyl-trans-resveratrol
- CAS No.
- 42206-94-0
- Chemical Name
- Acetyl-trans-resveratrol
- Synonyms
- Acethyl Resveratrol;Resveratrol triacetate;Resveratrol, Triacetyl;trans-Resveratrol Triacetate;Resveratrol 3,5,4'-triacetate;Triacetylresveratrol, ≥ 98.0%;3,5,4'-Tri-O-acetylresveratrol;Resveratrol Triacetate Impurity;3,4',5-Triacetoxy-trans-stilbene;ACETYL TRANS-RESVERATROL 42206-94-0
- CBNumber
- CB92469297
- Molecular Formula
- C20H18O6
- Formula Weight
- 354.35
- MOL File
- 42206-94-0.mol
Acetyl-trans-resveratrol Property
- Melting point:
- 117.0 to 121.0 °C
- Boiling point:
- 504.8±50.0 °C(Predicted)
- Density
- 1.241±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: ≥18mg/mL
- form
- White powder
- color
- white to tan
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Safety
- Hazard Codes
- Xi,N
- Risk Statements
- 37/38-41-43-50/53
- Safety Statements
- 26-36/37/39-60-61
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
- HS Code
- 2914390090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H335May cause respiratory irritation
H400Very toxic to aquatic life
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 554328
- Product name
- Resveratrol, Triacetyl
- Packaging
- 25mg
- Price
- $196
- Updated
- 2024/03/01
- Product number
- SML0032
- Product name
- Triacetyl resveratrol
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $103
- Updated
- 2023/06/20
- Product number
- T3232
- Product name
- Triacetyl resveratrol
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $17
- Updated
- 2024/03/01
- Product number
- T3232
- Product name
- Triacetyl resveratrol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $51
- Updated
- 2024/03/01
- Product number
- 26379
- Product name
- Acetyl Resveratrol
- Packaging
- 1g
- Price
- $89
- Updated
- 2024/03/01
Acetyl-trans-resveratrol Chemical Properties,Usage,Production
Description
Triacetyl resveratrol (CAS 42206-94-0) is a resveratrol prodrug. One method for increasing the half-life of resveratrol?in vivo?is acetylation of the phenolic OH groups. Deacetylation takes place?in vivo?or in intact cells via the action of intracellular esterases releasing active resveratrol.
Chemical Properties
White crystal or white crystal
Uses
trans-Resveratrol Triacetate is the acetylated analogue of Resveratrol (R150000) that is a natural antioxidant and a potential radioprotective agent. trans-Resveratrol Triacetate induces p53 activity and inhibits proliferation in breast and prostate tumor cell lines.
Definition
ChEBI: Acetic acid [4-[2-(3,5-diacetyloxyphenyl)ethenyl]phenyl] ester is a stilbenoid.
General Description
A cell-permeable triacetate resveratrol prodrug that is easily converted to resveratrol by esterase activity and exhibits similar bioactivity as resveratrol in cell cultures. Cremophor EL is reported to protect the prodrug from fast hydrolysis and resveratrol conversion in mouse serum at 37°C (100% conversion within 20 sec vs. >300 min or T1/2 of 48 min delivered with DMSO or 1:1:8 (v/v/v) EtOH/Cremophor EL/H2O, respectively; [prodrug]t=0 = 100 μM), although the active drug resveratrol is stable for more than 27 h under the same condition without Cremophor EL. When dosed at 10 mg/kg and delivered with 1:1:8 (v/v/v) EtOH/Cremophor EL/H2O intraperitoneally before, but not after, exposure to lethal γ-irradiation (9.75 Gy), the prodrug, but not resveratrol, is shown to greatly prevent irradiation-induced death in mice in vivo (survival rate = 77.4% with 10 mg/kg prodrug vs. ≤28.3% with 10 mg/kg resveratrol, vehicle alone, or no pretreatment at all).
Biochem/physiol Actions
Triacetyl resveratrol displays superior bioavailability to the parent compound, resveratrol. The compound induces p53 activity and inhibits proliferation in breast and prostate tumor cell lines.
Mechanism of action
After acetylated resveratrol enters the body, it is converted into resveratrol in the body to exert its biological activity. Acetylated Resveratrol Compared to Regular Resveratrol:
1) The stability is enhanced. Since the three active phenolic hydroxyl groups are acetylated, the stability of acetylated resveratrol is significantly improved;
2) The bioavailability is improved, due to prolonging the residence time in the body and increasing the half-life, the bioavailability is better. Acetylated resveratrol can be widely used in food, beverage and health care products.
in vitro
Triacetylresveratrol significantly down-regulates anti-apoptotic Bcl-2 family protein Mcl-1 and up-regulates pro-apoptotic Bcl-2 family proteins Bim and Puma. Triacetylresveratrol inhibits cell viability, and induces apoptosis of pancreatic cancer cells in a concentration and incubation time-dependent manner.
References
1) Hsieh?et al.?(2011),?Control of prostate cell growth, DNA damage and repair and gene expression by resveratrol analogues, in vitro; Carcinogenesis,?32?93 2) Hsieh?et al.?(2011),?Regulation of p53 and cell proliferation by resveratrol and it’s derivatives in breast cancer cells: an in silico and biochemical approach to targeting integrin αvβ3; Int. J. Cancer,?129?2732
Acetyl-trans-resveratrol Preparation Products And Raw materials
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View Lastest Price from Acetyl-trans-resveratrol manufacturers
- Product
- Acetyl Resveratrol 42206-94-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000 kg
- Release date
- 2024-04-21
- Product
- Acetyl Resveratrol 42206-94-0
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2022-10-25
- Product
- Acetyl-trans-resveratrol 42206-94-0
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-11-27