ChemicalBook > CAS DataBase List > Methyl 5-bromo-2-fluoronicotinate
Methyl 5-bromo-2-fluoronicotinate
- Product Name
- Methyl 5-bromo-2-fluoronicotinate
- CAS No.
- 931105-37-2
- Chemical Name
- Methyl 5-bromo-2-fluoronicotinate
- Synonyms
- Methyl 5-bromo-2-fluoronicotinate;5-Bromo-2-fluoro-nicotinic acid methyl ester;Methyl 5-broMo-2-fluoropyridine-3-carboxylate;5-Bromo-2-fluoro-3-pyridinecarboxylic acid methyl ester;3-Pyridinecarboxylic acid, 5-bromo-2-fluoro-, methyl ester
- CBNumber
- CB92471193
- Molecular Formula
- C7H5BrFNO2
- Formula Weight
- 234.02
- MOL File
- 931105-37-2.mol
More
Less
Methyl 5-bromo-2-fluoronicotinate Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- White to off-white Solid
More
Less
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
Frontier Specialty Chemicals
- Product number
- Y14218
- Product name
- Methyl5-bromo-2-fluoronicotinate
- Purity
- 98%
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 054271
- Product name
- Methyl 5-bromo-2-fluoronicotinate
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $51
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 054271
- Product name
- Methyl 5-bromo-2-fluoronicotinate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $79
- Updated
- 2021/12/16
Frontier Specialty Chemicals
- Product number
- Y14218
- Product name
- Methyl5-bromo-2-fluoronicotinate
- Purity
- 98%
- Packaging
- 5g
- Price
- $150
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC200226
- Product name
- Methyl5-bromo-2-fluoronicotinate
- Packaging
- 1g
- Price
- $195
- Updated
- 2021/12/16
More
Less
Methyl 5-bromo-2-fluoronicotinate Chemical Properties,Usage,Production
Synthesis
29241-66-5
74-88-4
931105-37-2
General procedure for the synthesis of methyl 2-fluoro-5-bromonicotinate from 2-fluoro-5-bromonicotinic acid and iodomethane: 0.75 mL (12 mmol) of iodomethane and 2.5 g (18 mmol) of potassium carbonate were added to a solution of 2.0 g (9.1 mmol) of 5-bromo-2-fluoronicotinic acid in DMF (8 mL). The reaction mixture was stirred at room temperature for 20 hours. After the reaction was completed, water was added to the reaction mixture and then extracted with ethyl acetate. The organic layer was washed with water and dried with anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure and purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate) to afford methyl 2-fluoro-5-bromonicotinate 1.7 g (7.3 mmol, 80% yield) as a white solid. Mass spectra (CI, m/z): 234, 236 [M + 1]+. 1H-NMR spectrum (400 MHz, DMSO-d6) δ: 8.66 (dd, J = 1.3, 2.6 Hz, 1H), 8.56 (dd, J = 2.6, 8.2 Hz, 1H), 3.89 (s, 3H).
References
[1] Patent: EP3333163, 2018, A1. Location in patent: Paragraph 1387; 1388
Methyl 5-bromo-2-fluoronicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
Methyl 5-bromo-2-fluoronicotinate Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 025-86918202 4000255188
- Fax
- 86-025-86918232
- sales@pharmablock.com
- Country
- China
- ProdList
- 5000
- Advantage
- 55
- Tel
- 0531-81313138 13066006660
- Fax
- QQ: 3366077777
- chibapharm@foxmail.com
- Country
- China
- ProdList
- 3991
- Advantage
- 55
- Tel
- 0319-5801333-8008 15630992918
- sales@summedchem.com
- Country
- China
- ProdList
- 965
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 02161555100
- Fax
- -
- Country
- China
- ProdList
- 820
- Advantage
- 58
- Tel
- 86-021-61559134 15921386130
- Fax
- 021-55068248
- 3423497944@qq.com
- Country
- China
- ProdList
- 8144
- Advantage
- 55
- Tel
- 025-57018978 18251899859
- Fax
- 025-57018008
- sales@chalf-pharm.com
- Country
- China
- ProdList
- 5674
- Advantage
- 50
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-87782433 18021532344
- Fax
- 025-87782433
- 1345332203@qq.com
- Country
- China
- ProdList
- 4134
- Advantage
- 58
- Tel
- 400-711-5280 86-571-81025280
- Fax
- 86-571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 9967
- Advantage
- 58
- Tel
- 021-021-021-31663258 13795219287
- Fax
- 021-31663258
- donghuanwen@126.com
- Country
- China
- ProdList
- 8816
- Advantage
- 58
- Tel
- 028-65791793 18140026355
- Fax
- QQ568470422
- 568470422@qq.com
- Country
- China
- ProdList
- 9997
- Advantage
- 58
- Tel
- 029-86115547 17791676824
- Fax
- 021-51602123
- sales@cochemical.com
- Country
- China
- ProdList
- 4006
- Advantage
- 58
- Tel
- +86-（0）57185586718; +8613336195806
- Fax
- +86-571-85864795
- sales@capot.com
- Country
- China
- ProdList
- 29735
- Advantage
- 60
- Tel
- 025-66061636 18013972705
- Fax
- (3)02557626880
- qqyang@aikonchem.com
- Country
- China
- ProdList
- 15814
- Advantage
- 58
- Tel
- 15026866316
- 180642609@qq.com
- Country
- China
- ProdList
- 4967
- Advantage
- 58
- Tel
- 0319-6931777 13930968617
- Fax
- +86-319-6931577
- 630669494@qq.com
- Country
- China
- ProdList
- 1021
- Advantage
- 58
- Tel
- 13651987816
- Fax
- -
- hongminpharm@163.com
- Country
- China
- ProdList
- 2326
- Advantage
- 58
- Tel
- 400-668-9898
- Fax
- 010-51582189
- service@3achem.com
- Country
- China
- ProdList
- 20557
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 021-58581007 18019463053
- Fax
- 021-50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12878
- Advantage
- 58
- Tel
- 027-69573188 18221423799
- 1503407886@qq.com
- Country
- China
- ProdList
- 1439
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58
- Tel
- +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- +86-0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25356
- Advantage
- 58
- Tel
- +8615986615575
- Fax
- 0086-13651442114
- info@codchem.com
- Country
- China
- ProdList
- 20342
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30229
- Advantage
- 58
- Tel
- +86-0086-577-64498589 +86-15355981851
- Fax
- 0086-577-56994596
- sales@win-winchemical.com
- Country
- China
- ProdList
- 14359
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- +8613580539051
- joe@yuhengpharm.com
- Country
- CHINA
- ProdList
- 21142
- Advantage
- 58
- Tel
- +86-0519-85551759 +8613506123987
- Fax
- +0086-519-85557389
- marketing1@neostarunited.com
- Country
- China
- ProdList
- 8830
- Advantage
- 58
- Tel
- 025-025-85560043 17301488900
- Fax
- 025-85563444
- info@synzest.com
- Country
- China
- ProdList
- 9286
- Advantage
- 58
- Tel
- 021-51816796-820 13611835272
- Fax
- 021-5161 3951
- sales2@sunwaypharm.com
- Country
- China
- ProdList
- 44119
- Advantage
- 58
- Tel
- 15662379806
- 845423637@qq.com
- Country
- China
- ProdList
- 1633
- Advantage
- 58
- Tel
- 0371-0371-55153829 18003835034
- 2853979819@qq.com
- Country
- China
- ProdList
- 9998
- Advantage
- 58
- Tel
- 183-0212-4410 18302124410
- Djt18302124410@163.com
- Country
- China
- ProdList
- 3000
- Advantage
- 58
- Tel
- 2383948258 19172820304
- 2383948258@qq.com
- Country
- China
- ProdList
- 12987
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29757
- Advantage
- 58
- Tel
- 13775267187
- 391097727@qq.com
- Country
- China
- ProdList
- 996
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- 0531-88924771 15614660963
- elsa.hang@strongerscience.com
- Country
- China
- ProdList
- 10623
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39653
- Advantage
- 58
- Tel
- 13230698506 18698089028
- 1725517238@qq.com
- Country
- China
- ProdList
- 5009
- Advantage
- 58
- Tel
- 0371-55695890 15637198702
- 1677336983@qq.com
- Country
- China
- ProdList
- 13191
- Advantage
- 58
- Tel
- 18621169109
- market03@meryer.com
- Country
- China
- ProdList
- 27987
- Advantage
- 58
- Tel
- 13356901049
- mark@sklnchem.cn
- Country
- China
- ProdList
- 7997
- Advantage
- 58
- Tel
- 17316103847
- sales@deleepharma.com
- Country
- China
- ProdList
- 230
- Advantage
- 58
- Tel
- 18455579438
- Country
- China
- ProdList
- 16684
- Advantage
- 58