Methyl 5-bromo-2-fluoronicotinate
- Product Name
- Methyl 5-bromo-2-fluoronicotinate
- CAS No.
- 931105-37-2
- Chemical Name
- Methyl 5-bromo-2-fluoronicotinate
- Synonyms
- Methyl 5-bromo-2-fluoronicotinate;5-Bromo-2-fluoro-nicotinic acid methyl ester;Methyl 5-broMo-2-fluoropyridine-3-carboxylate;5-Bromo-2-fluoro-3-pyridinecarboxylic acid methyl ester;3-Pyridinecarboxylic acid, 5-bromo-2-fluoro-, methyl ester
- CBNumber
- CB92471193
- Molecular Formula
- C7H5BrFNO2
- Formula Weight
- 234.02
- MOL File
- 931105-37-2.mol
Methyl 5-bromo-2-fluoronicotinate Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- White to off-white Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Y14218
- Product name
- Methyl5-bromo-2-fluoronicotinate
- Purity
- 98%
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 054271
- Product name
- Methyl 5-bromo-2-fluoronicotinate
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $51
- Updated
- 2021/12/16
- Product number
- 054271
- Product name
- Methyl 5-bromo-2-fluoronicotinate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $79
- Updated
- 2021/12/16
- Product number
- Y14218
- Product name
- Methyl5-bromo-2-fluoronicotinate
- Purity
- 98%
- Packaging
- 5g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- PC200226
- Product name
- Methyl5-bromo-2-fluoronicotinate
- Packaging
- 1g
- Price
- $195
- Updated
- 2021/12/16
Methyl 5-bromo-2-fluoronicotinate Chemical Properties,Usage,Production
Synthesis
29241-66-5
74-88-4
931105-37-2
General procedure for the synthesis of methyl 2-fluoro-5-bromonicotinate from 2-fluoro-5-bromonicotinic acid and iodomethane: 0.75 mL (12 mmol) of iodomethane and 2.5 g (18 mmol) of potassium carbonate were added to a solution of 2.0 g (9.1 mmol) of 5-bromo-2-fluoronicotinic acid in DMF (8 mL). The reaction mixture was stirred at room temperature for 20 hours. After the reaction was completed, water was added to the reaction mixture and then extracted with ethyl acetate. The organic layer was washed with water and dried with anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure and purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate) to afford methyl 2-fluoro-5-bromonicotinate 1.7 g (7.3 mmol, 80% yield) as a white solid. Mass spectra (CI, m/z): 234, 236 [M + 1]+. 1H-NMR spectrum (400 MHz, DMSO-d6) δ: 8.66 (dd, J = 1.3, 2.6 Hz, 1H), 8.56 (dd, J = 2.6, 8.2 Hz, 1H), 3.89 (s, 3H).
References
[1] Patent: EP3333163, 2018, A1. Location in patent: Paragraph 1387; 1388
Methyl 5-bromo-2-fluoronicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 5-bromo-2-fluoronicotinate Suppliers
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