2-chloro-Thiazolo[4,5-b]pyridine
- Product Name
- 2-chloro-Thiazolo[4,5-b]pyridine
- CAS No.
- 152170-30-4
- Chemical Name
- 2-chloro-Thiazolo[4,5-b]pyridine
- Synonyms
- 2-chlorothiazolo[4;2-Chlorthiazolo[4,5-b]pyridine;2-chloro-Thiazolo[4,5-b]pyridine;Thiazolo[4,5-b]pyridine, 2-chloro-
- CBNumber
- CB92473344
- Molecular Formula
- C6H3ClN2S
- Formula Weight
- 170.62
- MOL File
- 152170-30-4.mol
2-chloro-Thiazolo[4,5-b]pyridine Property
- Boiling point:
- 263.5±13.0 °C(Predicted)
- Density
- 1.531±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.95±0.50(Predicted)
- Appearance
- Light brown to brown Solid
- InChI
- InChI=1S/C6H3ClN2S/c7-6-9-5-4(10-6)2-1-3-8-5/h1-3H
- InChIKey
- RSDZXVRUWGEPQG-UHFFFAOYSA-N
- SMILES
- C12N=C(Cl)SC1=CC=CN=2
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C380648
- Product name
- 2-Chlorothiazolo[4,5-b]pyridine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 073760
- Product name
- 2-Chlorothiazolo[4,5-b]pyridine hydrochloride
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- OR903587
- Product name
- 2-Chlorothiazolo[4,5-b]pyridine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $218
- Updated
- 2021/12/16
- Product number
- 7H70-5-2C
- Product name
- 2-Chlorothiazolo[4,5-b]pyridine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 073760
- Product name
- 2-Chlorothiazolo[4,5-b]pyridine hydrochloride
- Purity
- 95+%
- Packaging
- 1g
- Price
- $363
- Updated
- 2021/12/16
2-chloro-Thiazolo[4,5-b]pyridine Chemical Properties,Usage,Production
Synthesis
99158-61-9
152170-30-4
The general procedure for the synthesis of 2-chlorothiazolo[4,5-b]pyridine from thiazolo[4,5-b]pyridine-2(3H)-thione was as follows: sulfuryl chloride (3.32 mL, 40.8 mmol) was slowly added to a dichloromethane (0.5 mL) suspension of thiazolo[4,5-b]pyridine-2-thiol (343 mg, 2.039 mmol). The reaction mixture was stirred at 50 °C for 2 h, followed by continued stirring at room temperature overnight. Upon completion of the reaction, ice water was added to the yellow suspension and stirred at room temperature for 15 minutes to quench the excess sulfuryl chloride. Subsequently, the pH was adjusted to 10-12 by adding ethyl acetate (EtOAc) and 4.0 N sodium hydroxide (NaOH) solution.The organic layer was separated, washed with saturated brine and dried over anhydrous sodium sulfate. After concentration under reduced pressure to remove the solvent, the crude product was dissolved in a small amount of chloroform and purified by column chromatography on silica gel (12 g silica gel), eluting first with 5% eluent for 3 min and then using a 12% gradient elution (5% to 60%). The fractions containing the target product were combined and concentrated under reduced pressure to give Intermediate 9A (265 mg, 1.553 mmol, 76% yield) as a white solid. The structure of the product was confirmed by 1H NMR (500 MHz, chloroform-d): δ 8.76 (dd, J = 5.0, 1.7 Hz, 1H), 8.19 (dd, J = 8.0, 1.7 Hz, 1H), 7.39 (dd, J = 8.0, 4.7 Hz, 1H); LC-MS analysis (Method A): retention time (RT) = 1.22 min, mass spectrum (ESI) m/z: 171 and 173 ([M + H]+).
References
[1] Patent: WO2018/13774, 2018, A1. Location in patent: Page/Page column 307
[2] Patent: WO2007/146066, 2007, A2. Location in patent: Page/Page column 92
2-chloro-Thiazolo[4,5-b]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-chloro-Thiazolo[4,5-b]pyridine manufacturers
- Product
- 2-chloro-Thiazolo[4,5-b]pyridine 152170-30-4
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02