6-Chloro-5-fluoro-nicotinic acid
- Product Name
- 6-Chloro-5-fluoro-nicotinic acid
- CAS No.
- 38186-86-6
- Chemical Name
- 6-Chloro-5-fluoro-nicotinic acid
- Synonyms
- 5-fluoro-6-chloronicotinic acid;6-Chloro-5-fluoro-nicotinic acid;6-Chloro-5-fluoropyridine-3-carboxylic acid;6-Chloro-5-fluoro-3-pyridinecarboxylic acid;2-Chloro-3-fluoropyridine-5-carboxylic acid;6-Chloro-5-fluoropyridine-3-carboyxlic acid;3-PYRIDINECARBOXYLIC ACID, 6-CHLORO-5-FLUORO-;6-chloro-5-fluoro-pyridine-3-carboxylic acid - [C86634];6-Chloro-5-fluoropyridine-3-carboxylic acid, 5-Carboxy-2-chloro-3-fluoropyridine;6-Chloro-5-fluoropyridine-3-carboxylic acid, 3-Carboxy-6-chloro-5-fluoropyridine
- CBNumber
- CB92473733
- Molecular Formula
- C6H3ClFNO2
- Formula Weight
- 175.54
- MOL File
- 38186-86-6.mol
6-Chloro-5-fluoro-nicotinic acid Property
- Boiling point:
- 314.2±37.0 °C(Predicted)
- Density
- 1.576±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.90±0.10(Predicted)
- form
- powder
- color
- Off-white
- InChI
- InChI=1S/C6H3ClFNO2/c7-5-4(8)1-3(2-9-5)6(10)11/h1-2H,(H,10,11)
- InChIKey
- YICIHICLGVXCGP-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=C(F)C=C1C(O)=O
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PC10650
- Product name
- 6-Chloro-5-fluoronicotinicacid
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 4H21-7-04
- Product name
- 6-Chloro-5-fluoronicotinic acid
- Packaging
- 250mg
- Price
- $88
- Updated
- 2021/12/16
- Product number
- C12734
- Product name
- 6-Chloro-5-fluoropyridine-3-carboxylicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 102789
- Product name
- 6-Chloro-5-fluoronicotinic acid
- Purity
- 98%
- Packaging
- 500mg
- Price
- $116
- Updated
- 2021/12/16
- Product number
- PC10650
- Product name
- 6-Chloro-5-fluoronicotinicacid
- Packaging
- 1g
- Price
- $203
- Updated
- 2021/12/16
6-Chloro-5-fluoro-nicotinic acid Chemical Properties,Usage,Production
Synthesis
34552-15-3
38186-86-6
2-Chloro-3-fluoro-5-methylpyridine (512 mg, 3.5 mmol) was used as starting material and dissolved in a solvent mixture of pyridine (2.5 mL) and water (2.5 mL). Potassium permanganate (1.1 g, 6.9 mmol) was added to this solution in batches and after the first addition, the reaction mixture was heated to 100 °C and stirred for 1 hour. Subsequently, additional potassium permanganate (totaling 3.3 g, 20.7 mmol) was added in two batches over a period of 2 hours. During the reaction, if solids accumulate in the condenser, it can be washed with water and pyridine. After continued stirring at 100 °C for 1 h, the reaction mixture was cooled to room temperature. The reaction was quenched with saturated aqueous Na2S2O3 and stirred for 30 minutes. The reaction mixture was filtered and the filtrate was acidified to pH 2 with 1.5 M HCl. The aqueous phase was extracted with EtOAc (3×), the organic phases were combined and washed with brine (1×), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by rapid chromatography on silica gel, using a gradient elution of 90% to 70% petroleum ether-EtOAc to afford 5-fluoro-6-chloronicotinic acid as a white solid (300 mg, 49% yield).
References
[1] Patent: WO2018/154118, 2018, A2. Location in patent: Page/Page column 106; 107
[2] Patent: WO2010/132016, 2010, A1. Location in patent: Page/Page column 91
6-Chloro-5-fluoro-nicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Chloro-5-fluoro-nicotinic acid manufacturers
- Product
- 6-Chloro-5-fluoro-nicotinic acid 38186-86-6
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99% min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
- Product
- 6-Chloro-5-fluoro-nicotinic acid 38186-86-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2019-12-31