ChemicalBook > CAS DataBase List > ONO-AE3-208

ONO-AE3-208

Product Name
ONO-AE3-208
CAS No.
402473-54-5
Chemical Name
ONO-AE3-208
Synonyms
AE 3-208;ONO-AE3-208;AE 3-208;ONO AE3 208;ONO-AE3-208;AE 3-208;ONO AE3 208;4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propanamido)phenyl)butanoic acid;4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]Benzenebutanoic acid;4-{4-Cyano-2-[2-(4-fluoro-naphthalen-1-yl)-propionylamino]-phenyl}-butyric acid;Benzenebutanoic acid, 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]-
CBNumber
CB92473788
Molecular Formula
C24H21FN2O3
Formula Weight
404.43
MOL File
402473-54-5.mol
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ONO-AE3-208 Property

Boiling point:
662.4±55.0 °C(Predicted)
Density 
1.30
storage temp. 
-20°C
solubility 
≥40.4 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥8.1 mg/mL in EtOH with gentle warming and ultrasonic
pka
4.69±0.10(Predicted)
form 
powder
color 
white to beige
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2076
Product name
ONO-AE3-208
Purity
≥98% (HPLC)
Packaging
5mg
Price
$131
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2076
Product name
ONO-AE3-208
Purity
≥98% (HPLC)
Packaging
25mg
Price
$530
Updated
2024/03/01
Cayman Chemical
Product number
14522
Product name
ONO-AE3-208
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
14522
Product name
ONO-AE3-208
Purity
≥98%
Packaging
5mg
Price
$130
Updated
2024/03/01
Cayman Chemical
Product number
14522
Product name
ONO-AE3-208
Purity
≥98%
Packaging
10mg
Price
$214
Updated
2024/03/01
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ONO-AE3-208 Chemical Properties,Usage,Production

Uses

ONO AE3 208 is a prostaglandin E receptor EP4 antagonist, which inhibits breast cancer metastasis.

Biological Activity

ono-ae3-208 is an antagonist of ep4 [1].ep4 is one of the prostaglandin e2 receptors and is associated with inflammatory disease and cancer such as prostate cancer. as an antagonist of ep4, ono-ae3-208 is expected to be a potential therapy for prostate cancer. in vitro assays show that ono-ae3-208 can suppress the migration and invasion of prostate cancer cells. 10μm of ono-ae3-208 decreases wound healing proportion of pc3 and lncap cell lines in wound-healing assay. and in transwell invasion assay, ono-ae3-208 inhibits cell invasion even at concentration of 0.1μm. ono-ae3-208 is also reported to suppress bone metastasis in vivo [1].since activation of e2 can increase the expression of matrix metalloproteinase (mmp) and release inflammatory cytokines, and then exacerbates abdominal aortic aneurism (aaa) formation, ono-ae3-208 is also used in the studies of aaa formation. it has been proved that ono-ae3-208 can cause the elastic fiber degradation and inhibit aaa formation in vivo in a dose-dependent manner [2].

storage

Store at -20°C

References

[1] song xu, zhengyu zhang, osamu ogawa,takeshi yoshikawa, hiromasa sakamoto, noboru shibasaki, akayuki goto, liming wang, naoki terada. an ep4 antagonist ono-ae3-208 suppresses cell invasion, migration and metastasis of prostate cancer. cell biochem biophys. 2014, april.
[2] utako yokoyama, ryo ishiwata, mei-hua jin, yuko kato, orie suzuki, huiling jin, yasuhiro ichikawa, syun kumagaya, yuzo katayama, takayuki fujita, satoshi okumura, motohiko sato, yukihiko sugimoto, hiroki aoki, shinichi suzuki, munetaka masuda, susumu minamisawa, yoshihiro ishikawa. inhibition of ep4 signaling attenuates aortic aneurysm formation. plos one. 2012, may. 7, 5, e36724.

ONO-AE3-208 Preparation Products And Raw materials

Raw materials

Preparation Products

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ONO-AE3-208 Suppliers

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402473-54-5, ONO-AE3-208Related Search:

Sulfanilic acid Sodium cyanoborohydride ETHYL 2-CYANOACRYLATE CJ 033466 CJ-21058 GW 627368X CJ-42794 L-161,982 Grapiprant

  • 4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]Benzenebutanoic acid
  • ONO-AE3-208
  • AE 3-208
  • AE 3-208;ONO AE3 208
  • ONO-AE3-208;AE 3-208;ONO AE3 208
  • Benzenebutanoic acid, 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]-
  • 4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propanamido)phenyl)butanoic acid
  • 4-{4-Cyano-2-[2-(4-fluoro-naphthalen-1-yl)-propionylamino]-phenyl}-butyric acid
  • 402473-54-5