ZD 7155

Product Name: ZD 7155
CAS No.: 151801-76-2
Chemical Name: ZD 7155
Synonyms: ZD 7155
CBNumber: CB92473849
Molecular Formula: C26H26N6O
Formula Weight: 438.52424
MOL File: 151801-76-2.mol

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Hazard and Precautionary Statements (GHS)

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ZD 7155 Chemical Properties,Usage,Production

Description

ZD 7155 hydrochloride is a potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. ZD 7155 hydrochloride displaces [125I]-angiotensin II binding with an IC50 value of 3.8 nM in guinea pig adrenal gland membranes.

Uses

ZD 7155 is an AT1R selective antagonist with renal function modulating activity. The effects of ZD 7155 on glomeruli and tubules were measured in 1- (N = 9) and 6-week-old (N = 13) lambs. Pretreatment with ZD 7155 after L-NAME infusion did not alter glomerular function in 1- or 6-week-old lambs. During postnatal development, Ang II modulates the effects of NO on electrolyte handling via AT1R and AT2R. In 6-week-old lambs, selective inhibition of AT1R and AT2R increased the excretion of Na+, K+, and Cl-. In 6-week-old lambs, pretreatment with ZD 7155 and PD 123319 followed by the addition of L-NAME increased urine flow rate by 200%, free water clearance by 50%, and decreased urine osmolality by 40%. The same trends of changes in these variables were also observed when L-NAME was added to ZD 7155 or PD 123319, although to a lesser extent.

References

[1] Glomerular and tubular effects of nitric oxide (NO) are regulated by angiotensin II (Ang II) in an age-dependent manner through activation of both angiotensin receptors (AT1Rs and AT2Rs) in conscious lambs DOI:10.1007/s00424-017-2053-4

ZD 7155 Preparation Products And Raw materials

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ZD 7155 Suppliers

China 2 United States 3 Global 5

InvivoChem

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InvivoChem

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TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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151801-76-2, ZD 7155Related Search:

5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE ICI D7114

ZD 7155

151801-76-2

C26H26N6O