N-(4-Cyanophenyl)guanidine

Product Name: N-(4-Cyanophenyl)guanidine
CAS No.: 5637-42-3
Chemical Name: N-(4-Cyanophenyl)guanidine
Synonyms: Etravirine Impurity 14;4-Guanidinobenzonitrile;4-Cyanophenyl Guanidine;N-(4-Cyanophenyl)guanidine;1-(4-cyanophenyl)guanidine;Guanidine, N-(4-cyanophenyl)-;N-(4-Cyanophenyl)guanidine,97%
CBNumber: CB92484667
Molecular Formula: C8H8N4
Formula Weight: 160.18
MOL File: 5637-42-3.mol

More

Less

N-(4-Cyanophenyl)guanidine Property

Melting point:: 155-162°C
Boiling point:: 316.6±44.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
vapor pressure: 0-0Pa at 20-25℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO, Methanol
form: Solid
pka: 9.91±0.10(Predicted)
color: Off-White
InChI: InChI=1S/C8H8N4/c9-5-6-1-3-7(4-2-6)12-8(10)11/h1-4H,(H4,10,11,12)
InChIKey: BTDGLZSKNFJBER-UHFFFAOYSA-N
SMILES: N(C1=CC=C(C#N)C=C1)C(=N)N
LogP: -2.2-0.4 at 20℃ and pH7.1-11

More

Less

Safety

HS Code: 2926.90.4801

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: C3387
Product name: 1-(4-Cyanophenyl)guanidine
Purity: >99.0%(HPLC)(N)
Packaging: 1g
Price: $27
Updated: 2025/07/31

TCI Chemical

Product number: C3387
Product name: 1-(4-Cyanophenyl)guanidine
Purity: >99.0%(HPLC)(N)
Packaging: 5g
Price: $57
Updated: 2025/07/31

TRC

Product number: C982120
Product name: N-(4-Cyanophenyl)guanidine
Packaging: 1g
Price: $135
Updated: 2021/12/16

TRC

Product number: C982120
Product name: N-(4-Cyanophenyl)guanidine
Packaging: 500mg
Price: $85
Updated: 2021/12/16

TRC

Product number: C982120
Product name: N-(4-Cyanophenyl)guanidine
Packaging: 5g
Price: $545
Updated: 2021/12/16

More

Less

N-(4-Cyanophenyl)guanidine Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

An intermediate in the preparation of Etravirine

Synthesis

420-04-2

873-74-5

5637-42-3

The general procedure for the synthesis of N-(4-cyanophenyl)guanidine from cyanamide and p-aminobenzonitrile is as follows: P-aminobenzonitrile (100 g), ethanol (500 ml), concentrated nitric acid (36 ml), and a 50% aqueous ammoniacal nitrile solution (54 ml) were mixed and heated to reflux. The reflux reaction was maintained for 16 hours. Upon completion of the reaction, the reaction mixture was cooled to 0 °C, followed by the slow addition of methyl tert-butyl ether (500 mL) at 0 to 5 °C. The mixture was continued to be stirred at 0 to 5 °C for 5 h. The precipitated solid was separated by filtration to give 59 g of guanidine nitrate. Guanidine nitrate (59 g) was dissolved in water (590 mL) and 1M sodium hydroxide solution (325 mL) was added. The precipitated solid was separated by filtration again and dried to give 33 g of 1-(4-cyanophenyl)guanidine.

References

[1] European Journal of Medicinal Chemistry, 2010, vol. 45, # 1, p. 244 - 255
[2] Patent: WO2012/1695, 2012, A1. Location in patent: Page/Page column 10
[3] Patent: US2013/96148, 2013, A1. Location in patent: Paragraph 0085; 0086
[4] Patent: US2015/336900, 2015, A1. Location in patent: Paragraph 0027; 0028

N-(4-Cyanophenyl)guanidine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-(4-Cyanophenyl)guanidine Suppliers

Americas 1 Canada 1 China 89 Europe 1 India 3 Japan 1 United Kingdom 1 United States 10 Global 107

Shanghai SynFarm Pharmaceutical Technology Co., Ltd.

Tel: 021-50793966 18917198199
Fax: +86-21-50793967
Email: info@synfarm.com
Country: China
ProdList: 280
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Shijiazhuang Sdyano Fine Chemical Co., Ltd.

Tel: 0311-89250318 031166536426
Fax: 4000311741
Email: master@sjzsdyn.com
Country: China
ProdList: 2809
Advantage: 65

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768836
Email: 1791901229@qq.com
Country: China
ProdList: 6950
Advantage: 52

Beijing Isomersyn Technology CO;LTD

Tel: 010-82954736 13391601435
Email: sales@isomersyn.com
Country: China
ProdList: 3295
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

More

Less

View Lastest Price from N-(4-Cyanophenyl)guanidine manufacturers

Henan Fengda Chemical Co., Ltd

Product: N-(4-Cyanophenyl)guanidine 5637-42-3
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-16

Career Henan Chemical Co

Product: 1-(4-Cyanophenyl)guanidine 5637-42-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-25

5637-42-3, N-(4-Cyanophenyl)guanidineRelated Search:

N-(4-Cyanophenyl)guanidine

4-Cyanophenyl Guanidine

4-Guanidinobenzonitrile

1-(4-cyanophenyl)guanidine

Guanidine, N-(4-cyanophenyl)-

N-(4-Cyanophenyl)guanidine,97%

Etravirine Impurity 14

5637-42-3

Intermediate of Etravirine

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals