ChemicalBook > CAS DataBase List > 5-(Hydroxymethyl)-alpha,alpha,alpha',alpha'-tetramethyl-1,3-benzenediacetonitrile

5-(Hydroxymethyl)-alpha,alpha,alpha',alpha'-tetramethyl-1,3-benzenediacetonitrile

Product Name
5-(Hydroxymethyl)-alpha,alpha,alpha',alpha'-tetramethyl-1,3-benzenediacetonitrile
CAS No.
120511-88-8
Chemical Name
5-(Hydroxymethyl)-alpha,alpha,alpha',alpha'-tetramethyl-1,3-benzenediacetonitrile
Synonyms
Anastrozole EP Impurity E;3,5-Bis(2-cyanoisopropyl) benzalcohol;Anastrozole Impurity 10（EP Impurity E）;Anastrozole Impurity 10（Anastrozole EP Impurity E）;2-[3-(1-Cyano-1-Methylethyl)-5-(hydroxyMethyl)phenyl]-2-;1,3-Benzenediacetonitrile, 5-(hydroxymethyl)-a1,a1,a3,a3-tet...;2,2'-[5-(Hydroxymethyl)-1,3-phenylene]bis(2-methylpropanenitrile);2,2'-[5-(hydroxymethyl)benzene-1,3- diyl]bis(2-methylpropanenitrile);1,3-Benzenediacetonitrile, 5-(hydroxymethyl)-a1,a1,a3,a3-tetramethyl-;1,3-Benzenediacetonitrile, 5-(hydroxyMethyl)-α1,α1,α3,α3-tetraMethyl-
CBNumber
CB92484788
Molecular Formula
C15H18N2O
Formula Weight
242.32
MOL File
120511-88-8.mol
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5-(Hydroxymethyl)-alpha,alpha,alpha',alpha'-tetramethyl-1,3-benzenediacetonitrile Property

Melting point:
150-160℃
Boiling point:
382.3±37.0 °C(Predicted)
Density 
1.084
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
14.34±0.10(Predicted)
color 
White to Off-White
InChI
InChI=1S/C15H18N2O/c1-14(2,9-16)12-5-11(8-18)6-13(7-12)15(3,4)10-17/h5-7,18H,8H2,1-4H3
InChIKey
PLEAQICJSGOGID-UHFFFAOYSA-N
SMILES
C1(C(C)(C)C#N)=CC(CO)=CC(C(C)(C)C#N)=C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
A637428
Product name
AnastrozoleEPImpurityE(2-[3-(Cyanodimethylmethyl)-5-hydroxymethylphenyl]-2-methylpropionitrile)
Packaging
10mg
Price
$205
Updated
2021/12/16
TRC
Product number
A637428
Product name
AnastrozoleEPImpurityE(2-[3-(Cyanodimethylmethyl)-5-hydroxymethylphenyl]-2-methylpropionitrile)
Packaging
100mg
Price
$1620
Updated
2021/12/16
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5-(Hydroxymethyl)-alpha,alpha,alpha',alpha'-tetramethyl-1,3-benzenediacetonitrile Chemical Properties,Usage,Production

Uses

2-[3-(Cyanodimethylmethyl)-5-hydroxymethylphenyl]-2-methylpropionitrile (Anastrozole EP Impurity E ) is an impurity of Anastrozole (A637425), an aromatase inhibitor which functions as an antineoplastic (1,2). Anastrozole is used in post-menopausal women with advanced breast cancer.

Definition

ChEBI: 2-[3-(2-cyanopropan-2-yl)-5-(hydroxymethyl)phenyl]-2-methylpropanenitrile is an alkylbenzene.

5-(Hydroxymethyl)-alpha,alpha,alpha',alpha'-tetramethyl-1,3-benzenediacetonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(Hydroxymethyl)-alpha,alpha,alpha',alpha'-tetramethyl-1,3-benzenediacetonitrile Suppliers

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View Lastest Price from 5-(Hydroxymethyl)-alpha,alpha,alpha',alpha'-tetramethyl-1,3-benzenediacetonitrile manufacturers

Henan Fengda Chemical Co., Ltd
Product
5-(Hydroxymethyl)-alpha,alpha,alpha',alpha'-tetramethyl-1,3-benzenediacetonitrile 120511-88-8
Price
US $80.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-27

120511-88-8, 5-(Hydroxymethyl)-alpha,alpha,alpha',alpha'-tetramethyl-1,3-benzenediacetonitrileRelated Search:

Anastrozole IMpurity (3-(1-Cyano-1-Methylethyl)-alfa,alfa-diMethyl-5-(1H-,1,2,4-triazole-1-ylMethyl)-benzeneacetaMide) p-Toluenesulfonic acid monohydrate Anastrozole Anastrozole IMpurity (3-(1-Cyano-1-Methylethyl)-alfa,alfa-diMethyl-5-(1H-,1,2,4-triazole-1-ylMethyl)-benzeneacetic acid) 5-Methyl-1,3-benzenediacetonitrile Anastrozole IMpurity (alfa1 , alfa1, alfa3, alfa3-TetraMethyl-5-(1H-1,2,4-triazol-1-ylMethyl)-1,3-BenzenediacetaMide) α,α,α’,α’-Tetramethyl-5-(dibromomethyl)-1,3-benzenediacetonitrile 3,5-Bis(2-cyanoprop-2-yl)toluene Di-Destriazole Anastrozole DiMer IMpurity 3,5-Bis(bromomethyl)toluene Anastrozole Impurity 11 2-[3-CHLOROMETHYL-5-(CYANO-DIMETHYL-METHYL)-PHENYL]-2-METHYL-PROPIONITRILE 2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-4-ylmethyl)phenyl]-2-methyl-propaneni Anastrozole N-glucuronide Anastrozole iMpurity Anastrozole IMpurity (alfa1 , alfa1, alfa3, alfa3-TetraMethyl-5-(1H-1,2,4-triazol-1-ylMethyl)-1,3-Benzenediacetic acid) α-Desmethyl Anastrozole 3,5-Bis(2-cyanoprop-2-yl)benzyl bromide

  • 2-[3-(1-Cyano-1-methylethyl)-5-(hydroxymethyl)phenyl]-2-methylpropanenitrile
  • 5-(Hydroxymethyl)-alpha,alpha,alpha',alpha'-tetramethyl-1,3-benzenediacetonitrile
  • 2-[3-(1-Cyano-1-Methylethyl)-5-(hydroxyMethyl)phenyl]-2-
  • 1,3-Benzenediacetonitrile, 5-(hydroxyMethyl)-α1,α1,α3,α3-tetraMethyl-
  • Anastrozole EP Impurity E
  • 2,2'-[5-(Hydroxymethyl)-1,3-phenylene]bis(2-methylpropanenitrile)
  • 2,2'-[5-(hydroxymethyl)benzene-1,3- diyl]bis(2-methylpropanenitrile)
  • Anastrozole Impurity 10（EP Impurity E）
  • 1,3-Benzenediacetonitrile, 5-(hydroxymethyl)-a1,a1,a3,a3-tetramethyl-
  • Anastrozole Impurity 10（Anastrozole EP Impurity E）
  • 2,2'-(5-(Hydroxymethyl)-1,3-phenylene)bis(2-methylpropanenitrile) (Anastrozole Impurity)
  • 1,3-Benzenediacetonitrile, 5-(hydroxymethyl)-a1,a1,a3,a3-tet...
  • 3,5-Bis(2-cyanoisopropyl) benzalcohol
  • 2-[3-(cyano-dimethyl-methyl)-5-hydroxymethyl-phenyl]-2-methyl-propionitrile
  • d . 2,2′-[5-(d i b romome th yl)b e nze ne -1,3-d i yl]b i s(2-me th ylpropa ne ni tri le ),
  • 2,2'-(5-(Hydroxymethyl)-1,3-phenylene)bis(2-methylpropanenitrile) (Anastrozole Impurity)
  • 5-(Hydroxymethyl)-alpha,alpha,alpha',alpha'-tetramethyl-1,3-benzenediacetonitrile
  • 120511-88-8