3,5-Bis(2-cyanoprop-2-yl)benzyl bromide

Product Name: 3,5-Bis(2-cyanoprop-2-yl)benzyl bromide
CAS No.: 120511-84-4
Chemical Name: 3,5-Bis(2-cyanoprop-2-yl)benzyl bromide
Synonyms: forAnastrozole;Methylpropiononitrile);Anastrozol EP impurity C;Anastrozole EP Impurity C;Anastrozole EP Impuriyt C;α'-TetraMethyl-5-broMoMethyl-1;Anastrozole Monobromo Impurity;Anastrozole USP Related Compound D;Bromobenzyl-bis-dimethylacetonitrile;Anastrozole Impurity 8（EP Impurity C）
CBNumber: CB6213413
Molecular Formula: C15H17BrN2
Formula Weight: 305.21
MOL File: 120511-84-4.mol

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3,5-Bis(2-cyanoprop-2-yl)benzyl bromide Property

Melting point:: 98-100°C
Boiling point:: 380.0±37.0 °C(Predicted)
Density: 1.276±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
InChI: InChI=1S/C15H17BrN2/c1-14(2,9-17)12-5-11(8-16)6-13(7-12)15(3,4)10-18/h5-7H,8H2,1-4H3
InChIKey: IHXHGCDOJLOZML-UHFFFAOYSA-N
SMILES: C1(C(C)(C)C#N)=CC(CBr)=CC(C(C)(C)C#N)=C1
CAS DataBase Reference: 120511-84-4(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

TRC

Product number: T291490
Product name: α,α,α’,α’-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile
Packaging: 50mg
Price: $95
Updated: 2021/12/16

TRC

Product number: T291490
Product name: α,α,α’,α’-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile
Packaging: 500mg
Price: $700
Updated: 2021/12/16

TRC

Product number: T291490
Product name: α,α,α’,α’-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile
Packaging: 1g
Price: $1165
Updated: 2021/12/16

Biosynth Carbosynth

Product number: IT28173
Product name: a,a,a',a'-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile
Packaging: 50mg
Price: $180
Updated: 2021/12/16

Matrix Scientific

Product number: 084327
Product name: 2-[3-(Bromomethyl)-5-(1-cyano-1-methylethyl)-phenyl]-2-methylpropanenitrile
Purity: 97%
Packaging: 1g
Price: $230
Updated: 2021/12/16

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3,5-Bis(2-cyanoprop-2-yl)benzyl bromide Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

α,α,α’,α’-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile (Anastrozole EP Impurity C) is an impurity of Anastrozole (A637425) (impurity D).

Synthesis

120511-72-0

120511-84-4

Using 5,α,α,α',α'-pentamethyl-1,3-benzenediacetonitrile as raw material, 3,5-bis(1-cyano-1-methylethyl)toluene (600 g, 2.65 mol) was obtained after step III. The product was mixed with N-bromosuccinimide (519 g, 2.916 mol) and benzoyl peroxide (17 g, 0.053 mol) in carbon tetrachloride (4.5 L) and the reaction was carried out at reflux for 2 to 2.5 hours. After completion of the reaction, the reaction mixture was cooled and filtered. The filtrate was concentrated to dryness at 40°C to 45°C. The resulting solid was dissolved in 2-propanol (2L) at 75°C to 80°C, followed by slow cooling to 10°C to 15°C and stirring at this temperature for 1 hour. The reaction mixture was further cooled to -5 °C to 0 °C and stirring was continued for 2 h, after which it was filtered and the filter cake was washed with pre-cooled 2-propanol (200 ml). The filter cake was subsequently washed with hexane and blotted dry. Finally, the filter cake was dried under vacuum at 40 °C to 45 °C to afford the target product 3,5-bis(1-cyano-1-methylethyl)benzyl bromide (700.2 g, 87.0% yield).

References

[1] Patent: US2006/189670, 2006, A1. Location in patent: Page/Page column 5; 7
[2] Patent: US2006/35950, 2006, A1. Location in patent: Page/Page column 3; 11
[3] Patent: CN103554041, 2016, B. Location in patent: Paragraph 0014-0016
[4] Patent: US2009/221837, 2009, A1. Location in patent: Page/Page column 4
[5] Patent: WO2007/39913, 2007, A1. Location in patent: Page/Page column 14

3,5-Bis(2-cyanoprop-2-yl)benzyl bromide Preparation Products And Raw materials

Raw materials

Preparation Products

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3,5-Bis(2-cyanoprop-2-yl)benzyl bromide Suppliers

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View Lastest Price from 3,5-Bis(2-cyanoprop-2-yl)benzyl bromide manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3,5-Bis(2-cyanoprop-2-yl)benzyl bromide 120511-84-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-07

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 3,5-Bis(2-cyanoprop-2-yl)benzyl bromide 120511-84-4
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 90%min
Supply Ability: 500kg
Release date: 2021-09-17

Henan Aochuang Chemical Co.,Ltd.

Product: 3,5-Bis(2-cyanoprop-2-yl)benzyl bromide 120511-84-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-28

120511-84-4, 3,5-Bis(2-cyanoprop-2-yl)benzyl bromideRelated Search:

Benzyl alcohol Sodium bromate 3'-(Trifluoromethyl)acetophenone Ethidium bromide Benzyl isocyanate Methyl 4-(bromomethyl)benzoate 4-BROMO-2,2-DIPHENYLBUTYRONITRILE BROMOPENTAMETHYLBENZENE Benzyl chloride Benzyl bromide Allyl bromide 2'-Methylacetophenone 4'-Bromoacetophenone Benzyl nicotinate Benzyl benzoate p-Nitrophenylacetonitrile 2-Bromoacetophenone Diphenylacetonitrile

5-(BROMOMETHYL)-A,A,A,A-TETRAMETHYL-1,3-BENZENEDIACETONITRILE

5-BROMOMETHYL-A,A,A',A'-TETRAMETHYL-1,3-BENZENEDIACETONITRILE

5-(BROMOMETHYL)-ALPHA,ALPHA,ALPHA,ALPHA-TETRAMETHYL-1,3-BENZENEDIACETONITRILE

1,3-Benzenediacetonitrile, 5-(bromomethyl)-α,α,α',α'-tetramethyl-

Anastrozole EP Impurity C

2-2'-[5-(Bromomethyl)benzene-1,3- diyl]bis(2-methylpropanenitrile)

3,5-Bis(1-cyano-1-methylethyl)benzyl Bromide

Anastrozole USP Related Compound D

Anastrozole EP Impuriyt C

α'-TetraMethyl-5-broMoMethyl-1

1,3-Benzenediacetonitrile,5-(bromomethyl)-a,a,a',a'-tetramethyl-

Anastrozole Impurity 8（EP Impurity C）

a,a,a',a'-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile

5-BROMOMETHYLTETRAMETHYL-1,3-BENZENEDIACETONITRILE

3,5-Bis(2-cyanoprop-2-yl)benzyl bromide

2,2-(5-BROMOMETHYL-1,3-PHENYLENE) DI(2-METHYLPROPIONONITRILE)

2,2'-(5-BROMOMETHYL-1,3-PHENYLENE)-DI-(2-METHYLPROPIONITRILE)

5-BROMOMETHYL-A,A,A',A'-TETRAMETHYL-1,3-BENZENEDIACETONITRIL

3,5-Bis(1-Cyano-1-Methylethyl)BromomethylBenezene(ForAnastrozole)

3,5-Bis(1-cyano-1-methylethyl)bromomethylbenezene

forAnastrozole

5-(BROMOMETHYI)-A,A,A'',A''-TETRAMETHYI-1,3-BENZENEDIACETONITRILE

2-[3-(Cyanodimethylmethyl)-5-bromomethylphenyl]-2-methylpropionitrile

2-[3-(Bromomethyl)-5-(1-cyano-1-methylethyl)phenyl]-2-methylpropanenitrile

5-Bromomethyl-α,α,α',α'-tetramethyl-1,3-benzenediacetonitril

α,α,α’,α’-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile

2,2'-(5-(broMoMethyl)-1,3-phenylene)bis(2-Methylpropanenitrile)

5-(bromomethyl)-α,α,α',α'-tetramethyl-

5-(BroMoMethyl)-α1,α1,α3,α3-tetraMethyl-

1,3-Benzenediacetonitrile,5-(broMoMethyl)-a1,a1,a3,a3-tetraMethyl-

Methylpropiononitrile)

2,2'(5-BroMoMethyl -1,3-phenylene)-di-(2-Methylpronitrile)

1,3-Benzenediacetonitrile, 5-(broMoMethyl)-α1,α1,α3,α3-tetraMethyl-

Anastrozole Impurity 8（Anastrozole EP Impurity C）

Anastrozole Monobromo Impurity

3,5-Bis(2-cyanoprop-2-yl)benzyl bromide(For export only)

Bromobenzyl-bis-dimethylacetonitrile

5-(bromomethyl)-a,a,a',a'-tetramethyl- (9CI)

2,2'-(5-(Bromomethyl)-1,3-phenylene)bis(2-methylpropanenitrile) (Anastrozole Impurity)

Anastrozole EP Impurity CQ: What is Anastrozole EP Impurity C Q: What is the CAS Number of Anastrozole EP Impurity C Q: What is the storage condition of Anastrozole EP Impurity C Q: What are the applications of Anastrozole EP Impurity C

b . (2RS)-2,3-b i s[3-(1-c ya no-1-me th yle th yl)-5-(1h -1,2,4-tri a zol-1-ylme th yl)ph e nyl]-2-me th ylpropa ne ni tri le ,

5-(Bromomethyl)-α1,α1,α3,α3-tetramethyl-1,3-benzenediacetonitrile

α,α,a’,a’-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile

α,α,α',α'-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile

Anastrozol EP impurity C

2,2'-(5-BROMOMETHYL-1,3-PHENYLENE)-DI-(2-METHYLPROPIONITRILE...

2,2'-[5-(Bromomethyl)benzene-1,3-diyl]bis(2-methylpropanenitrile)

alpha,alpha,alpha’,alpha’-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile

2,2'-(5-(Bromomethyl)-1,3-phenylene)bis(2-methylpropanenitrile) - [B72422]

5-Bromomethyl-alpha1,alpha1,alpha3,alpha3-tetramethyl-1,3-benzenediacetonitrile

120511-84-4

C15H17BrN2

Methyl Halides

Phenyls & Phenyl-Het

Anastrazole

Aromatics

Impurities

Intermediates & Fine Chemicals