ChemicalBook > CAS DataBase List > 11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one

11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one

Product Name: 11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
CAS No.: 1012884-46-6
Chemical Name: 11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
Synonyms: Asenapine interMediate;6,7]oxepino[4,5-c]pyrrol-1-one;11-chloro-2,3-dihydro-2-Methyl-1H-dibenz[2,3;11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5...;11-Chloro-2,3-dihydro-2-Methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c];11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one;1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one,11-chloro-2,3-dihydro-2-methyl-;11-chloro-2-Methyl-2,3-dihydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one;11-Chloro-2,3-dihydro-2-Methyl-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one;11-chloro-2,3-dihydro-2-methyl-1H-dibenzo [2,3: 6,7] oxazolo [4,5-c] pyrrole-1-one
CBNumber: CB92485048
Molecular Formula: C17H12ClNO2
Formula Weight: 297.74
MOL File: 1012884-46-6.mol

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11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one Property

Boiling point:: 530.8±50.0 °C(Predicted)
Density: 1.43
storage temp.: Sealed in dry,Store in freezer, under -20°C
pka: -1.29±0.20(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C17H12ClNO2/c1-19-9-13-11-4-2-3-5-14(11)21-15-7-6-10(18)8-12(15)16(13)17(19)20/h2-8H,9H2,1H3
InChIKey: KXKUDCTZEMWVDQ-UHFFFAOYSA-N
SMILES: N1(C)CC2C3=CC=CC=C3OC3=CC=C(Cl)C=C3C=2C1=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C990543
Product name: 11-Chloro-2-methyl-2,3-dihydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
Packaging: 2mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: J52032
Product name: 11-Chloro-2-methyl-2,3-dihydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
Packaging: 1g
Price: $18
Updated: 2021/12/16

AK Scientific

Product number: 0363AA
Product name: 11-Chloro-2-methyl-2,3-dihydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
Packaging: 1g
Price: $25
Updated: 2021/12/16

AK Scientific

Product number: J11227
Product name: 11-Chloro-2-methyl-2,3-dihydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one[Asenapineimpurity]
Packaging: 25mg
Price: $57
Updated: 2021/12/16

AK Scientific

Product number: J11227
Product name: 11-Chloro-2-methyl-2,3-dihydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one[Asenapineimpurity]
Packaging: 100mg
Price: $198
Updated: 2021/12/16

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11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one Chemical Properties,Usage,Production

Synthesis

1162120-35-5

1012884-46-6

Anhydrous aluminum chloride (5 g) was slowly added to a solution of monochlorobenzene (1 mL) containing 3-(5-chloro-2-phenoxyphenyl)-1-methylpyrrolidine-2,4-dione (1 g) at room temperature. The reaction system was warmed to 98 °C with continuous stirring for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature. Subsequently, a mixed solution consisting of water (50 mL) and concentrated hydrochloric acid (5 mL) was slowly added. After continuing to stir for 30 minutes, hexane (50 mL) was added. The mixture was stirred for 1 h. The mixture was filtered and the resulting solid was washed with hexane (15 mL) and dried in air at 30 °C for 15 h to afford 11-chloro-2,3-dihydro-2-methyl-1H-dibenzo[2,3:6,7]oxepino[4,5-C]pyrrol-1-one in 97% yield.

References

[1] Patent: WO2013/11461, 2013, A1. Location in patent: Page/Page column 11-13
[2] Patent: US2015/112083, 2015, A1. Location in patent: Paragraph 0053
[3] Organic Process Research and Development, 2008, vol. 12, # 2, p. 196 - 201

11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

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11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one Suppliers

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View Lastest Price from 11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one manufacturers

Career Henan Chemical Co

Product: 11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one 1012884-46-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-09

1012884-46-6, 11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-oneRelated Search:

1467115-23-6 Asenapine related impurities N-DesMethyl Asenapine-d4 Asenapine-N-beta-D-glucuronide 1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one, 11-chloro-2,3,3a,12b-tetrahydro-2-Methyl-, (3aR,12bS)-rel- 5-Chloro-2-methyl-2,3-dihydrodibenzo[2,3:6,7]oxepino[4,5-c]pyrrole-(2H)-one Asenapine Maleate NA Saphris hydrochloride N-Desmethyl Asenapine Hydrochloride Asenapine N-b-D-glucuronide Asenapine-13C-D3 hydrochloride Asenapine [13C,2H3]-Asenapine maleate,racemic mixture [13C，2H3]-Asenapine N-β-D-Glucuronide Trifluoroacetic Acid Salt N-Desmethylasenapine hydrochloride, racemic mixture [13C,2H3]-Asenapine Maleate NKNYMFHSPDODLJ-YIYRCGFGSA-N

11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one

Asenapine interMediate

11-Chloro-2,3-dihydro-2-Methyl-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one

11-Chloro-2,3-dihydro-2-Methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]

11-chloro-2,3-dihydro-2-Methyl-1H-dibenz[2,3

6,7]oxepino[4,5-c]pyrrol-1-one

11-chloro-2-Methyl-2,3-dihydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one

1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one,11-chloro-2,3-dihydro-2-methyl-

11-chloro-2,3-dihydro-2-methyl-1H-dibenzo [2,3: 6,7] oxazolo [4,5-c] pyrrole-1-one

11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one USP/EP/BP

11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5...

11-chlorine-2,3-dihydrogen-2-methyl-1H-dibenzo[2,3:6,7]Oxazosin[4,5-C]Pyrrole-1-ketone

1012884-46-6