ChemicalBook > CAS DataBase List > 11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
- Product Name
- 11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
- CAS No.
- 1012884-46-6
- Chemical Name
- 11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
- Synonyms
- Asenapine interMediate;6,7]oxepino[4,5-c]pyrrol-1-one;11-chloro-2,3-dihydro-2-Methyl-1H-dibenz[2,3;11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5...;11-Chloro-2,3-dihydro-2-Methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c];11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one;1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one,11-chloro-2,3-dihydro-2-methyl-;11-chloro-2-Methyl-2,3-dihydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one;11-Chloro-2,3-dihydro-2-Methyl-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one;11-chloro-2,3-dihydro-2-methyl-1H-dibenzo [2,3: 6,7] oxazolo [4,5-c] pyrrole-1-one
- CBNumber
- CB92485048
- Molecular Formula
- C17H12ClNO2
- Formula Weight
- 297.74
- MOL File
- 1012884-46-6.mol
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11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one Property
- Boiling point:
- 530.8±50.0 °C(Predicted)
- Density
- 1.43
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- pka
- -1.29±0.20(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C17H12ClNO2/c1-19-9-13-11-4-2-3-5-14(11)21-15-7-6-10(18)8-12(15)16(13)17(19)20/h2-8H,9H2,1H3
- InChIKey
- KXKUDCTZEMWVDQ-UHFFFAOYSA-N
- SMILES
- N1(C)CC2C3=CC=CC=C3OC3=CC=C(Cl)C=C3C=2C1=O
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N-Bromosuccinimide Price
TRC
- Product number
- C990543
- Product name
- 11-Chloro-2-methyl-2,3-dihydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
- Packaging
- 2mg
- Price
- $60
- Updated
- 2021/12/16
AK Scientific
- Product number
- J11227
- Product name
- 11-Chloro-2-methyl-2,3-dihydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one[Asenapineimpurity]
- Packaging
- 100mg
- Price
- $198
- Updated
- 2021/12/16
AK Scientific
- Product number
- J52032
- Product name
- 11-Chloro-2-methyl-2,3-dihydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
- Packaging
- 1g
- Price
- $18
- Updated
- 2021/12/16
AK Scientific
- Product number
- 0363AA
- Product name
- 11-Chloro-2-methyl-2,3-dihydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
AK Scientific
- Product number
- J11227
- Product name
- 11-Chloro-2-methyl-2,3-dihydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one[Asenapineimpurity]
- Packaging
- 25mg
- Price
- $57
- Updated
- 2021/12/16
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11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one Chemical Properties,Usage,Production
Synthesis
1162120-35-5
1012884-46-6
Anhydrous aluminum chloride (5 g) was slowly added to a solution of monochlorobenzene (1 mL) containing 3-(5-chloro-2-phenoxyphenyl)-1-methylpyrrolidine-2,4-dione (1 g) at room temperature. The reaction system was warmed to 98 °C with continuous stirring for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature. Subsequently, a mixed solution consisting of water (50 mL) and concentrated hydrochloric acid (5 mL) was slowly added. After continuing to stir for 30 minutes, hexane (50 mL) was added. The mixture was stirred for 1 h. The mixture was filtered and the resulting solid was washed with hexane (15 mL) and dried in air at 30 °C for 15 h to afford 11-chloro-2,3-dihydro-2-methyl-1H-dibenzo[2,3:6,7]oxepino[4,5-C]pyrrol-1-one in 97% yield.
References
[1] Patent: WO2013/11461, 2013, A1. Location in patent: Page/Page column 11-13
[2] Patent: US2015/112083, 2015, A1. Location in patent: Paragraph 0053
[3] Organic Process Research and Development, 2008, vol. 12, # 2, p. 196 - 201
11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
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11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one Suppliers
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View Lastest Price from 11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one manufacturers
Career Henan Chemical Co
- Product
- 11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one 1012884-46-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-09
1012884-46-6, 11-Chloro-2,3-dihydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-oneRelated Search:
1467115-23-6
Asenapine related impurities
N-DesMethyl Asenapine-d4
Asenapine-N-beta-D-glucuronide
1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one, 11-chloro-2,3,3a,12b-tetrahydro-2-Methyl-, (3aR,12bS)-rel-
5-Chloro-2-methyl-2,3-dihydrodibenzo[2,3:6,7]oxepino[4,5-c]pyrrole-(2H)-one
Asenapine Maleate
NA
Saphris hydrochloride
N-Desmethyl Asenapine Hydrochloride
Asenapine N-b-D-glucuronide
Asenapine-13C-D3 hydrochloride
Asenapine
[13C,2H3]-Asenapine maleate,racemic mixture
[13C，2H3]-Asenapine N-β-D-Glucuronide Trifluoroacetic Acid Salt
N-Desmethylasenapine hydrochloride, racemic mixture
[13C,2H3]-Asenapine Maleate
NKNYMFHSPDODLJ-YIYRCGFGSA-N