3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester

Product Name: 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester
CAS No.: 1083057-14-0
Chemical Name: 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester
Synonyms: tert-Butyl 3-(6-aMino-3-Methylpyridin-2-yl)benzoate;EOS-61004;VX-809 intermediate;tert-butyl 3-(6-amino-3-methylpyridin-2-yl)benzoat;3-(6-amino-3-methylpyridine-2-yl) tert-butyl benzoate;3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester;3-(6-Amino-3-methyl-pyridin-2-yl)-benzoic acid tert-butyl es...;Tert-butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate(For export only);Benzoic acid, 3-(6-aMino-3-Methyl-2-pyridinyl)-, 1,1-diMethylethyl ester
CBNumber: CB92489657
Molecular Formula: C17H20N2O2
Formula Weight: 284.35
MOL File: 1083057-14-0.mol

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3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester Property

Boiling point:: 439.7±45.0 °C(Predicted)
Density: 1.119±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka: 5.95±0.34(Predicted)
Appearance: Light yellow to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: Z3873
Product name: tert-Butyl3-(6-amino-3-methylpyridin-2-yl)benzoate
Packaging: 100mg
Price: $127
Updated: 2021/12/16

ChemScene

Product number: CS-M2542
Product name: Benzoicacid,3-(6-amino-3-methyl-2-pyridinyl)-,1,1-dimethylethylester
Purity: 98.13%
Packaging: 1g
Price: $208
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0394020
Product name: TERT-BUTYL-3-(6-AMINO-3-METHYLPYRIDIN-2-YL)BENZOATE
Purity: 95.00%
Packaging: 5MG
Price: $496.21
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 35111
Product name: tert-Butyl3-(6-amino-3-methylpyridin-2-yl)benzoate
Purity: 95+%
Packaging: 100mg
Price: $720
Updated: 2021/12/16

ChemScene

Product number: CS-M2542
Product name: Benzoicacid,3-(6-amino-3-methyl-2-pyridinyl)-,1,1-dimethylethylester
Purity: 98.13%
Packaging: 250mg
Price: $77
Updated: 2021/12/16

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3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester Chemical Properties,Usage,Production

Synthesis

1083057-13-9

1083057-14-0

The general procedure for the synthesis of tert-butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate from 2-(3-(tert-butoxycarbonyl)phenyl)-3-methylpyridine-1-oxide is as follows: a mixture of 2-(3-(tert-butoxycarbonyl)phenyl)-3-methylpyridine-1-oxide (1 eq.) and pyridine (4 eq.) in acetonitrile (8 vol.) was heated to 70 °C. A solution of methylsulfonic anhydride (1.5 eq.) in acetonitrile (2 vol.) was slowly added through the addition funnel over 50 min, and the reaction temperature was controlled below 75 °C. After the addition was completed, stirring of the reaction mixture was continued for 0.5 hours. The reaction mixture was then cooled to room temperature. Ethanolamine (10 equivalents) was added through the addition funnel and after stirring the reaction for 2 hours, water (6 volumes) was added and the mixture was cooled to 10°C. After continued stirring for not less than 3 hours, the solid product was collected by filtration. The solid was washed sequentially with water (3 volumes), a 2:1 acetonitrile/water mixture (3 volumes) and acetonitrile (2 x 1.5 volumes). The solid was dried in a vacuum oven at 50 °C to constant weight (less than 1% change in weight) and kept under a slight stream of nitrogen to give tert-butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate as a reddish yellow solid in 53% yield.

References

[1] Patent: WO2009/76142, 2009, A2. Location in patent: Page/Page column 54
[2] Patent: WO2009/73757, 2009, A1. Location in patent: Page/Page column 23
[3] Patent: WO2010/37066, 2010, A2. Location in patent: Page/Page column 12; 28-29
[4] Patent: US2013/186801, 2013, A1. Location in patent: Paragraph 0371; 0372
[5] Patent: WO2013/185112, 2013, A1. Location in patent: Paragraph 00569

3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester Suppliers

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Shanghai Boyle Chemical Co., Ltd.

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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

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China Shenyang Tyschem CO. ,LTD

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ShangHai Onsyn-Chemical Technology Co., Ltd.

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View Lastest Price from 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester 183057-14-0
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-08-07

Career Henan Chemical Co

Product: 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester 1083057-14-0
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g； 1kg; 25kg
Release date: 2020-01-10

Career Henan Chemical Co

Product: 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester 1083057-14-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-17

1083057-14-0, 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylesterRelated Search:

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3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester

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Benzoic acid, 3-(6-aMino-3-Methyl-2-pyridinyl)-, 1,1-diMethylethyl ester

EOS-61004

VX-809 intermediate

tert-butyl 3-(6-amino-3-methylpyridin-2-yl)benzoat

Tert-butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate(For export only)

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1083057-14-0

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