2-Oxo-(2H)-furo(2,3-h)-1-benzopyran
Synthesis Toxicity- Product Name
- 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran
- CAS No.
- 523-50-2
- Chemical Name
- 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran
- Synonyms
- angecin;ANGELICIN;ANGELICINE;NSC 404563;isopsoralin;ISOPSORALEN;ISOPSORALENE;ISOBERGAPTEN;ANGELICIN(P);Angelicin>
- CBNumber
- CB9249112
- Molecular Formula
- C11H6O3
- Formula Weight
- 186.16
- MOL File
- 523-50-2.mol
2-Oxo-(2H)-furo(2,3-h)-1-benzopyran Property
- Melting point:
- 132-134°C
- Boiling point:
- 104°C/4mmHg(lit.)
- Density
- 1.2477 (rough estimate)
- refractive index
- 1.6310 (estimate)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White
- λmax
- 302nm(EtOH)(lit.)
- BRN
- 153970
- LogP
- 2.080
- CAS DataBase Reference
- 523-50-2(CAS DataBase Reference)
- IARC
- 3 (Vol. 40, Sup 7) 1987
- NIST Chemistry Reference
- 2H-furo[2,3-h]-1-benzopyran-2-one(523-50-2)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38-40
- Safety Statements
- 26-36/37/39-37/39-36
- WGK Germany
- 3
- RTECS
- LV0940000
- HS Code
- 29322090
- Hazardous Substances Data
- 523-50-2(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A0956
- Product name
- Angelicin
- Packaging
- 10mg
- Price
- $159.6
- Updated
- 2024/03/01
- Product number
- A0956
- Product name
- Angelicin
- Packaging
- 25mg
- Price
- $349.8
- Updated
- 2024/03/01
- Product number
- A2573
- Product name
- Angelicin
- Purity
- >98.0%(GC)
- Packaging
- 25mg
- Price
- $411
- Updated
- 2024/03/01
- Product number
- 11683
- Product name
- Angelicin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $98
- Updated
- 2024/03/01
- Product number
- 11683
- Product name
- Angelicin
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $157
- Updated
- 2024/03/01
2-Oxo-(2H)-furo(2,3-h)-1-benzopyran Chemical Properties,Usage,Production
Synthesis
Iodination of commercially available umbelliferone (7-hydroxycoumarin) yields 7-hydroxy-8-iodocoumarin. Acetoxy group can be introduced into hydroxyl of 7-hydroxy-8-iodocoumarin, which is used to create vaginol or vaginidiol with an isopropyl Grignard reagent and commercially available epoxy aldehydes. Subsequent acid-catalysed fragmentation of vaginol with dichloromethane in trifluoroacetic acid yields angelicin.
Toxicity
The LD50 of angelicin is 322 mg/kg which shows acute toxicity if orally administered to rats. The possible consequences are alteration in circadian rhythm and righting reflex, ataxia and analgesia.
Description
Angelicin is a furanocoumarin typically isolated from the seeds of P. corylifolia. Like other furanocoumarins, angelicin has antibacterial activities against a number of Gram (+) and Gram (-) bacteria. It has also been shown to prevent tacrine-
Chemical Properties
White Solid
Uses
Antifungal
Definition
ChEBI: Angelicin is a furanocoumarin.
Synthesis Reference(s)
Tetrahedron, 51, p. 3087, 1995 DOI: 10.1016/0040-4020(95)00070-O
Clinical Use
Angelicin derivatives are used to treat psoriasis and cancer. One way of treating these diseases is by photochemotherapy (PUVA) which combines UV irradiation with photosensitizing chemical. Also, it was shown that it is actively inhibits the synthesis of nucleic acids in tumor cells thereby decreasing their growth.
2-Oxo-(2H)-furo(2,3-h)-1-benzopyran Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran manufacturers
- Product
- 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran 523-50-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- ≥98%
- Supply Ability
- 20tons
- Release date
- 2024-01-04
- Product
- Angelicin 523-50-2
- Price
- US $1050.00/g
- Min. Order
- 1g
- Purity
- 98
- Supply Ability
- 500 Kg
- Release date
- 2024-03-31
- Product
- Isopsoralen 523-50-2
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-10-24