Psoralen

Description References

Product Name: Psoralen
CAS No.: 66-97-7
Chemical Name: Psoralen
Synonyms: FICUSIN;Furocoumarin;Psoralene;Psoralea extract;7H-Furo[3,2-g]chromen-7-one;7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE;PSORALEN;Prosuler;Psorline-P;NSC 404562
CBNumber: CB3181900
Molecular Formula: C11H6O3
Formula Weight: 186.16
MOL File: 66-97-7.mol

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Psoralen Property

Melting point:: 160-162 °C
Boiling point:: 280.64°C (rough estimate)
Density: 1.2477 (rough estimate)
refractive index: 1.6310 (estimate)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
color: White to Off-White
Water Solubility: 65.16mg/L(25 ºC)
λmax: 328nm(EtOH)(lit.)
Merck: 14,7928
BRN: 152784
InChIKey: ZCCUUQDIBDJBTK-UHFFFAOYSA-N
LogP: 1.670
CAS DataBase Reference: 66-97-7(CAS DataBase Reference)
NIST Chemistry Reference: 7H-furo[3,2-g][1]benzopyran-7-one(66-97-7)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 3
RTECS: LV0944000
F: 8-10
HS Code: 29339900
Hazardous Substances Data: 66-97-7(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P8399
Product name: Psoralen
Purity: ≥99% (HPLC)
Packaging: 10mg
Price: $129
Updated: 2024/03/01

Sigma-Aldrich

Product number: 73633
Product name: Psoralen
Purity: analytical standard
Packaging: 10mg
Price: $508
Updated: 2022/05/15

TCI Chemical

Product number: P2077
Product name: Psoralen
Purity: >99.0%(GC)
Packaging: 20mg
Price: $70
Updated: 2024/03/01

TCI Chemical

Product number: P2077
Product name: Psoralen
Purity: >99.0%(GC)
Packaging: 100mg
Price: $209
Updated: 2024/03/01

Alfa Aesar

Product number: J60042
Product name: Psoralen, 97%
Packaging: 100mg
Price: $241.65
Updated: 2024/03/01

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Psoralen Chemical Properties,Usage,Production

Description

Psoralen is a kind of naturally occurring furocoumarin. It is naturally occurred in the seeds of Psoralea corylifolia as well as in the common fig, celery, parsley, West Indian Satinwood and all citrus fruits. It is capable of binding to DNA via single- and double-strand cross-linking upon photoactivation with UV radiation. It can intercalate with DNA, blocking its synthesis and cell division. For this reason, it is an important mutagen and can be used in related molecular biology studies. It also exhibits anti- proliferative, anti-allergenic and anti-histamine functions. It can also be used in PUVA treatment for skin diseases such as psoriasis, eczema and vitiligo. It is also effective tanning activator in sunscreens. Some of its derivatives, e.g. amino-psoralen, amotosalen HCl, can even inactivate pathogens in blood products.

References

https://en.wikipedia.org/wiki/Psoralen
https://pubchem.ncbi.nlm.nih.gov/compound/Psoralen#section=Top

Chemical Properties

Crystalline Solid

Uses

Use as photochemical probe in biological systems

Uses

Psoralens are phytoalexins; they are used by plants in a defensive response to attacks by fungi and insects. They have also shown photosensitizing and phototoxic effects in animals and humans and have been used in photochemotherapy for management of vitiligo, psoriasis, and mycosis fungoides. Used as photochemical probe in biological systems.

Uses

As photochemical probe in biological systems: P.-S. Song, C.-N. Ou, Ann. N.Y. Acad. Sci. 346, 355 (1980).

Definition

ChEBI: The simplest member of the class of psoralens that is 7H-furo[3,2-g]chromene having a keto group at position 7. It has been found in plants like Psoralea corylifolia and Ficus salicifolia.

Synthesis Reference(s)

Journal of the American Chemical Society, 106, p. 6735, 1984 DOI: 10.1021/ja00334a044
Synthetic Communications, 37, p. 63, 2007 DOI: 10.1080/00397910600978093

Biochem/physiol Actions

Psoralen belongs to the linear type furanocoumarins. It intercalates and induces interstrand cross-links in DNA. On UV exposure psoralen is excited leading to irreversible intercalation with DNA by covalent bond formation. This property of psoralen ultraviolet A light (PUVA) is exploited in treating skin diseases and cutaneous T-cell lymphoma. However, usage psoralen also leads to hepatotoxicity and cytotoxicity by the generation of psoralen photoproducts (POPs). It may be useful in treating osteoporosis

Psoralen Preparation Products And Raw materials

Raw materials

Preparation Products

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Psoralen Suppliers

Canada 2 China 272 Czech Republic 1 Europe 1 France 3 Germany 4 India 12 Japan 1 Switzerland 2 Ukraine 1 United Kingdom 10 United States 43 USA 1 Global 353

Nanjing Spring & Autumn Biological Engineering Co., Ltd.

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J & K SCIENTIFIC LTD.

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Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
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Chembest Research Laboratories Limited

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Email: sales@BioChemBest.com
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
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JinYan Chemicals(ShangHai) Co.,Ltd.

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Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9984
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Chemsky（shanghai）International Co.,Ltd.

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Email: shchemsky@sina.com
Country: China
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Shandong Xiya Chemical Co., Ltd

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BEST-REAGENT

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China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
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Aktin Chemicals, Inc.

Tel: 86-28-85159085
Fax: 86-28-85152372
Email: info@aktinchem.com
Country: China
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View Lastest Price from Psoralen manufacturers

Chongqing Zhihe Biopharmaceutical Co., Ltd.

Product: Psoralen 66-97-7
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: ≥98%
Supply Ability: 20tons
Release date: 2024-01-04

BINBO BIOLOGICAL CO.,LTD

Product: Psoralen 66-97-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 1000 kg
Release date: 2024-04-16

Shaanxi Dideu Medichem Co. Ltd

Product: Psoralen 66-97-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

66-97-7, PsoralenRelated Search:

Coumarin 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran Psoralen-mop BAVACHIN Bergapten BERGAPTOL psoralen,4,5’,8-trimethyl Imperatorin Bergamotine OXYPEUCEDANIN ISOPIMPINELLIN 3-(HYDROXYMETHYL)-2,5,9-TRIMETHYL-7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE ALLOISOIMPERATORIN XANTHOTOXOL Isoimperatorin BYAKANGELICIN 3-(alpha,alpha-dimethylallyl)psoralen 7H-Furo3,2-g1benzopyran-7-one, 3-methoxy-2-(1-methylethyl)-

PSORALEN

Fructus Psoraleae extract

Psoralen, >=99%

TGRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRY MJJNNNNNNN

Psoralea corylifolia Linn. Extract

furo(2’,3’,7,6)coumarin

furo(2’,3’:7’,6)coumarin

Furo(4',5',6,7)coumarin

furo(4’,5’,6,7)coumarin

furo(4’,5’:6,7)coumarin

Furo[2',3':7,6]coumarin

Furo[2'.3':7.6]coumarin

Furo[2’,3’:7,6]coumarin

furo[3,2-g]chromen-2-one

Furo[3,2-g]chromen-7-one

Psoralen, froM Psoralea corylifolia L.

Psoralen, 99%, from Psoralea corylifolia L.

PSORALEN, FOR FLUORESCENCE

6-Hydroxy-5-benzofuranacrylic acid γ-lactone

PSORALEN90%

PSORALEN(SH)

PSORALEN hplc

PSORALEN WITH HPLC

7H-Furo[3,2-γ],[1]benzopyran-7-one

Furo[3,2-γ],coumarin

7H-Furo[3,2-g]benzopyran-7-one, Furo[3,2-g]coumarin

7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE

7h-furo[3,2-g]benzopyran-7-one

FURO[3,2-G]BENZOPYRAN-7-ONE

FURO[3,2-G]COUMARIN

FICUSIN

2-Propenoic acid, 3-(6-hydroxy-5-benzofuranyl)-, delta-lactone

2-Propenoicacid,3-(6-hydroxy-5-benzofuranyl)-,δ-lactone

3-(6-hydroxy-5-benzofuranyl)-2-propenoicacidelta-lactone

5-Benzofuranacrylic acid, 6-hydroxy-, delta-lactone

6,7-Furanocoumarin

6-hydroxy-5-benzofuranacrylicacidbeta-lactone

6-hydroxy-5-benzofuranacrylicacidelta-lactone

7H-Furo[3,2-g]chromen-7-one

Furo(2',3',7,6)coumarin

Furo[4',5':6,7]coumarin

Furo[4’,5’:6,7]coumarin

Furocoumarin

Psoralene

Psorline-P

Psoralen,7H-Furo[3,2-g]benzopyran-7-one, Furo[3,2-g]coumarin

Psoralen (Ficusin)

3-(6-Hydroxy-5-benzofuranyl)-2-propenoic Acid δ-Lactone

NSC 404562

Prosuler

Psoralea extract

7-furo[3,2-g][1]benzopyranone

Extract psoralen extract

in stock Psoralen 66-97-7

PSORALEAE FRUCTUS

Psoralen&gt

Psoralen USP/EP/BP

Psoralen (psoralene, Ficusin, Furocoumarin)