XANTHOTOXOL
- Product Name
- XANTHOTOXOL
- CAS No.
- 2009-24-7
- Chemical Name
- XANTHOTOXOL
- Synonyms
- 9-hydroxy-;NSC 401269;XANTHOTOXOL;AKOS 210-08;Xanthotoxol?, BR;8-HYDROXYPSORALEN;Xanthotoxol (6CI);8-hydroxypsoralene;XANTHOTOXOL IMpurity;XANTHOTOXOL(RG)(CALL)
- CBNumber
- CB9438695
- Molecular Formula
- C11H6O4
- Formula Weight
- 202.16
- MOL File
- 2009-24-7.mol
XANTHOTOXOL Property
- Melting point:
- 250°C
- Boiling point:
- 428.1±45.0 °C(Predicted)
- Density
- 1.526±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 5.74±0.20(Predicted)
- color
- Light Beige to Dark Brown
- LogP
- 1.405 (est)
Safety
- Risk Statements
- 25
- Safety Statements
- 20-45-24/25
- RIDADR
- 2810
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 27801
- Product name
- Xanthotoxol
- Packaging
- 5mg
- Price
- $76
- Updated
- 2024/03/01
- Product number
- 27801
- Product name
- Xanthotoxol
- Packaging
- 25mg
- Price
- $315
- Updated
- 2024/03/01
- Product number
- 27801
- Product name
- Xanthotoxol
- Packaging
- 10mg
- Price
- $135
- Updated
- 2024/03/01
- Product number
- X742500
- Product name
- Xanthotoxol
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 292055
- Product name
- Xanthotoxol
- Packaging
- 1g
- Price
- $319
- Updated
- 2021/12/16
XANTHOTOXOL Chemical Properties,Usage,Production
Description
Xanthotoxol is a coumarin and a major component in C. monnieri that has diverse biological activities. It inhibits proliferation of HeLa and HepG2 cells in vitro (IC50s = 23.59 and 15.57 μM, respectively). Xanthotoxol increases histamine release from mast cells and decreases secretion of TNF-α, IL-4, and IL-1β from RBL-2H3 cells induced by DNP-human serum albumin (DNP-HSA). It is nematocidal against M. incognita (IC50 = 68 mg/L). In vivo, xanthotoxol inhibits predatory mouse and rat killing behavior in dogs and cats when administered at doses ranging from 3 to 100 mg/kg and 5 to 20 mg/kg, respectively. It reduces amphetamine-induced hypermobility in mice and hamsters. Xanthotoxol (5 and 10 mg/kg) reduces brain edema, neutrophil infiltration, blood-brain barrier disruption, production of IL-1β, TNF-α, IL-8, and nitric oxide (NO), and levels of intercellular adhesion molecule-1 (ICAM-1) and E-selectin in a rat model of focal cerebral ischemia.
Chemical Properties
Dark Brown Solid
Uses
A hydroxylated psoralen that inhibits neutrophil infiltration and brain edema induced by focal cerebral ischemia-reperfusion injury in rats. A potentially useful antiarrhythmic agent. It has been shown to be effective in the prevention of ventricular fibrillation of mice induced by chloroform, of rats induced by calcium chloride, and in treatment of rat arrhythmia induced by aconitine. Recent studies show that it may also have antioxidant and anticancer activities.
Uses
Xanthotoxol is a hydroxylated psoralen that inhibits neutrophil infiltration and brain edema induced by focal cerebral ischemia-reperfusion injury in rats. A potentially useful antiarrhythmic agent. It has been show n to be effective in the prevention of ventricular fibrillation of mice induced by chloroform, of rats induced by calcium chloride, and in treatment of rat arrhythmia induced by aconitine. Recent stud ies show that it may also have antioxidant and anticancer activities.
Definition
ChEBI: Xanthotoxol is an 8-hydroxyfurocoumarin.
Synthesis Reference(s)
Synthetic Communications, 37, p. 361, 2007 DOI: 10.1080/00397910601038616
XANTHOTOXOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from XANTHOTOXOL manufacturers
- Product
- Xanthotoxol 2009-24-7
- Price
- US $0.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-03-10
- Product
- XANTHOTOXOL 2009-24-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-29
- Product
- Xanthotoxol 2009-24-7
- Price
- US $0.01-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50 tons
- Release date
- 2020-04-27