ChemicalBook > CAS DataBase List > XANTHOTOXOL

XANTHOTOXOL

Product Name
XANTHOTOXOL
CAS No.
2009-24-7
Chemical Name
XANTHOTOXOL
Synonyms
9-hydroxy-;NSC 401269;XANTHOTOXOL;AKOS 210-08;Xanthotoxol-RM;Xanthotoxol(AS);Xanthotoxol?, BR;8-HYDROXYPSORALEN;Xanthotoxol (6CI);8-hydroxypsoralene
CBNumber
CB9438695
Molecular Formula
C11H6O4
Formula Weight
202.16
MOL File
2009-24-7.mol
More
Less

XANTHOTOXOL Property

Melting point:
250°C
Boiling point:
428.1±45.0 °C(Predicted)
Density 
1.526±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
5.74±0.20(Predicted)
color 
Light Beige to Dark Brown
LogP
1.405 (est)
More
Less

Safety

Risk Statements 
25
Safety Statements 
20-45-24/25
RIDADR 
2810
HS Code 
29329990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
27801
Product name
Xanthotoxol
Packaging
5mg
Price
$76
Updated
2024/03/01
Cayman Chemical
Product number
27801
Product name
Xanthotoxol
Packaging
25mg
Price
$315
Updated
2024/03/01
Cayman Chemical
Product number
27801
Product name
Xanthotoxol
Packaging
10mg
Price
$135
Updated
2024/03/01
TRC
Product number
X742500
Product name
Xanthotoxol
Packaging
1g
Price
$60
Updated
2021/12/16
Usbiological
Product number
292055
Product name
Xanthotoxol
Packaging
1g
Price
$319
Updated
2021/12/16
More
Less

XANTHOTOXOL Chemical Properties,Usage,Production

Description

Xanthotoxol is a coumarin and a major component in C. monnieri that has diverse biological activities. It inhibits proliferation of HeLa and HepG2 cells in vitro (IC50s = 23.59 and 15.57 μM, respectively). Xanthotoxol increases histamine release from mast cells and decreases secretion of TNF-α, IL-4, and IL-1β from RBL-2H3 cells induced by DNP-human serum albumin (DNP-HSA). It is nematocidal against M. incognita (IC50 = 68 mg/L). In vivo, xanthotoxol inhibits predatory mouse and rat killing behavior in dogs and cats when administered at doses ranging from 3 to 100 mg/kg and 5 to 20 mg/kg, respectively. It reduces amphetamine-induced hypermobility in mice and hamsters. Xanthotoxol (5 and 10 mg/kg) reduces brain edema, neutrophil infiltration, blood-brain barrier disruption, production of IL-1β, TNF-α, IL-8, and nitric oxide (NO), and levels of intercellular adhesion molecule-1 (ICAM-1) and E-selectin in a rat model of focal cerebral ischemia.

Chemical Properties

Dark Brown Solid

Uses

A hydroxylated psoralen that inhibits neutrophil infiltration and brain edema induced by focal cerebral ischemia-reperfusion injury in rats. A potentially useful antiarrhythmic agent. It has been shown to be effective in the prevention of ventricular fibrillation of mice induced by chloroform, of rats induced by calcium chloride, and in treatment of rat arrhythmia induced by aconitine. Recent studies show that it may also have antioxidant and anticancer activities.

Uses

Xanthotoxol is a hydroxylated psoralen that inhibits neutrophil infiltration and brain edema induced by focal cerebral ischemia-reperfusion injury in rats. A potentially useful antiarrhythmic agent. It has been show n to be effective in the prevention of ventricular fibrillation of mice induced by chloroform, of rats induced by calcium chloride, and in treatment of rat arrhythmia induced by aconitine. Recent stud ies show that it may also have antioxidant and anticancer activities.

Definition

ChEBI: Xanthotoxol is an 8-hydroxyfurocoumarin.

Synthesis Reference(s)

Synthetic Communications, 37, p. 361, 2007 DOI: 10.1080/00397910601038616

More
Less

XANTHOTOXOL Suppliers

Changzhou Pumelo Co.,Ltd.
Tel
0519-81698808 13809072999
Fax
0519-81698098
Email
pml@pmlchem.com
Country
China
ProdList
59
Advantage
55
Shanghai Yihe Biological Technology Co., Ltd.
Tel
17721395025
Fax
021-68882955
Email
2423903095@qq.com
Country
China
ProdList
3683
Advantage
58
ChengDu YiRui Bio-Technology CO., LTD
Tel
182-24028459 18224018291
Fax
QQ137193152
Email
3004072879@qq.com
Country
China
ProdList
1195
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Shanghai Harvest Chemical Industrial Co., Ltd.
Tel
21-31038972 15721252604
Fax
+86-21-51385350
Email
ammyzuo@harvest-chem.com
Country
China
ProdList
2540
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
More
Less

View Lastest Price from XANTHOTOXOL manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Xanthotoxol 2009-24-7
Price
US $0.00/mg
Min. Order
20mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-03-10
Dideu Industries Group Limited
Product
XANTHOTOXOL 2009-24-7
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-29
Career Henan Chemical Co
Product
XANTHOTOXOL 2009-24-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-07-09

2009-24-7, XANTHOTOXOLRelated Search:


  • 2-g)(1)benzopyran-7-one,9-hydroxy-7h-furo(
  • 6,7-dihydroxy-5-benzofuranacrylicacigamma-lactone
  • 8-hydroxypsoralene
  • 9-hydroxy-7h-furo(3,2-g)(1)benzopyran-7-one
  • 9-hydroxyfuro[3,2-g]chromen-7-one
  • 9-hydroxy-
  • Xanthotoxol, froM CnidiuM Monnieri
  • XANTHOTOXOL
  • 8-HYDROXYPSORALEN
  • AKOS 210-08
  • 7H-Furo[3,2-g][1]benzopyran-7-one, 9-hydroxy-
  • 3-(6,7-Dihydroxy-5-benzofuranyl)-2-propenoic Acid δ-Lactone
  • 6,7-Dihydroxy-5-benzofuranacrylic Acid δ-Lactone
  • NSC 401269
  • XANTHOTOL; XANTHOTOXOL
  • XANTHOTOXOL(RG)(CALL)
  • 9-hydroxy-7H-furo[3,2-g]chromen-7-one
  • Xanthotoxol, 98%, from Cnidium monnieri
  • Xanthotoxol?, BR
  • 8-Hydroxyfuranocoumarin
  • XANTHOTOXOL ISO 9001:2015 REACH
  • Xanthotoxol (6CI)
  • XANTHOTOXOL IMpurity
  • Xanthotoxol(AS)
  • Xanthotoxol-RM
  • 2009-24-7
  • C11H6O4
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Coumarins
  • API intermediates