XANTHOTOXOL

ChemicalBook > CAS DataBase List > XANTHOTOXOL

Product Name: XANTHOTOXOL
CAS No.: 2009-24-7
Chemical Name: XANTHOTOXOL
Synonyms: 9-hydroxy-;NSC 401269;XANTHOTOXOL;AKOS 210-08;Xanthotoxol-RM;Xanthotoxol(AS);Xanthotoxol?, BR;8-HYDROXYPSORALEN;Xanthotoxol (6CI);8-hydroxypsoralene
CBNumber: CB9438695
Molecular Formula: C11H6O4
Formula Weight: 202.16
MOL File: 2009-24-7.mol

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XANTHOTOXOL Property

Melting point:: 250°C
Boiling point:: 428.1±45.0 °C(Predicted)
Density: 1.526±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 5.74±0.20(Predicted)
color: Light Beige to Dark Brown
LogP: 1.405 (est)

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Safety

Risk Statements: 25
Safety Statements: 20-45-24/25
RIDADR: 2810
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27801
Product name: Xanthotoxol
Packaging: 5mg
Price: $76
Updated: 2024/03/01

Cayman Chemical

Product number: 27801
Product name: Xanthotoxol
Packaging: 25mg
Price: $315
Updated: 2024/03/01

Cayman Chemical

Product number: 27801
Product name: Xanthotoxol
Packaging: 10mg
Price: $135
Updated: 2024/03/01

TRC

Product number: X742500
Product name: Xanthotoxol
Packaging: 1g
Price: $60
Updated: 2021/12/16

TRC

Product number: X742500
Product name: Xanthotoxol
Packaging: 5g
Price: $165
Updated: 2021/12/16

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XANTHOTOXOL Chemical Properties,Usage,Production

Description

Xanthotoxol is a coumarin and a major component in C. monnieri that has diverse biological activities. It inhibits proliferation of HeLa and HepG2 cells in vitro (IC₅₀s = 23.59 and 15.57 μM, respectively). Xanthotoxol increases histamine release from mast cells and decreases secretion of TNF-α, IL-4, and IL-1β from RBL-2H3 cells induced by DNP-human serum albumin (DNP-HSA). It is nematocidal against M. incognita (IC₅₀ = 68 mg/L). In vivo, xanthotoxol inhibits predatory mouse and rat killing behavior in dogs and cats when administered at doses ranging from 3 to 100 mg/kg and 5 to 20 mg/kg, respectively. It reduces amphetamine-induced hypermobility in mice and hamsters. Xanthotoxol (5 and 10 mg/kg) reduces brain edema, neutrophil infiltration, blood-brain barrier disruption, production of IL-1β, TNF-α, IL-8, and nitric oxide (NO), and levels of intercellular adhesion molecule-1 (ICAM-1) and E-selectin in a rat model of focal cerebral ischemia.

Chemical Properties

Dark Brown Solid

Uses

A hydroxylated psoralen that inhibits neutrophil infiltration and brain edema induced by focal cerebral ischemia-reperfusion injury in rats. A potentially useful antiarrhythmic agent. It has been shown to be effective in the prevention of ventricular fibrillation of mice induced by chloroform, of rats induced by calcium chloride, and in treatment of rat arrhythmia induced by aconitine. Recent studies show that it may also have antioxidant and anticancer activities.

Uses

Xanthotoxol is a hydroxylated psoralen that inhibits neutrophil infiltration and brain edema induced by focal cerebral ischemia-reperfusion injury in rats. A potentially useful antiarrhythmic agent. It has been show n to be effective in the prevention of ventricular fibrillation of mice induced by chloroform, of rats induced by calcium chloride, and in treatment of rat arrhythmia induced by aconitine. Recent stud ies show that it may also have antioxidant and anticancer activities.

Definition

ChEBI: Xanthotoxol is an 8-hydroxyfurocoumarin.

Synthesis Reference(s)

Synthetic Communications, 37, p. 361, 2007 DOI: 10.1080/00397910601038616

XANTHOTOXOL Preparation Products And Raw materials

Raw materials

Osmium tetroxide 7-Hydroxycoumarin Acetic anhydride Acetone Phosphoric acid Hydrogen peroxide Sodium sulfate Potassium carbonate 1,4-Dioxane Aluminum chloride Ethyl acetate Potassium periodate Allyl bromide Methanol Sodium hydroxide Pyridine N,N-Diethylaniline

Preparation Products

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XANTHOTOXOL Suppliers

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View Lastest Price from XANTHOTOXOL manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Xanthotoxol 2009-24-7
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-03-10

Dideu Industries Group Limited

Product: XANTHOTOXOL 2009-24-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-29

Career Henan Chemical Co

Product: XANTHOTOXOL 2009-24-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-07-09

2009-24-7, XANTHOTOXOLRelated Search:

8-Methoxypsoralen XANTHORRHIZOL Xanthiazone 2'-HYDROXY-4',6'-DIMETHOXYACETOPHENONE XANTHOSINE Xanthiside Xanthohumol xanthatin Imperatorin XANTHOTOXOL ISOPIMPINELLIN BYAKANGELICIN heraclenin XANTHOTOXOL(RG) phellopterin BYAKANGELICIN NEOBYAKANGELICOL BYAKANGELICOL

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6,7-dihydroxy-5-benzofuranacrylicacigamma-lactone

8-hydroxypsoralene

9-hydroxy-7h-furo(3,2-g)(1)benzopyran-7-one

9-hydroxyfuro[3,2-g]chromen-7-one

9-hydroxy-

Xanthotoxol, froM CnidiuM Monnieri

XANTHOTOXOL

8-HYDROXYPSORALEN

AKOS 210-08

7H-Furo[3,2-g][1]benzopyran-7-one, 9-hydroxy-

3-(6,7-Dihydroxy-5-benzofuranyl)-2-propenoic Acid δ-Lactone

6,7-Dihydroxy-5-benzofuranacrylic Acid δ-Lactone

NSC 401269

XANTHOTOL; XANTHOTOXOL

XANTHOTOXOL(RG)(CALL)

9-hydroxy-7H-furo[3,2-g]chromen-7-one

Xanthotoxol, 98%, from Cnidium monnieri

Xanthotoxol?, BR

8-Hydroxyfuranocoumarin

XANTHOTOXOL ISO 9001：2015 REACH

Xanthotoxol (6CI)

XANTHOTOXOL IMpurity

Xanthotoxol(AS)

Xanthotoxol-RM

2009-24-7

C11H6O4

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Coumarins

API intermediates