Description References
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Psoralen

Description References
Product Name
Psoralen
CAS No.
66-97-7
Chemical Name
Psoralen
Synonyms
FICUSIN;Furocoumarin;Psoralene;Psoralea extract;7H-Furo[3,2-g]chromen-7-one;7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE;PSORALEN;Prosuler;Psorline-P;NSC 404562
CBNumber
CB3181900
Molecular Formula
C11H6O3
Formula Weight
186.16
MOL File
66-97-7.mol
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Psoralen Property

Melting point:
160-162 °C
Boiling point:
280.64°C (rough estimate)
Density 
1.2477 (rough estimate)
refractive index 
1.6310 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
color 
White to Off-White
Water Solubility 
65.16mg/L(25 ºC)
λmax
328nm(EtOH)(lit.)
Merck 
14,7928
BRN 
152784
InChIKey
ZCCUUQDIBDJBTK-UHFFFAOYSA-N
LogP
1.670
CAS DataBase Reference
66-97-7(CAS DataBase Reference)
NIST Chemistry Reference
7H-furo[3,2-g][1]benzopyran-7-one(66-97-7)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
RTECS 
LV0944000
8-10
HS Code 
29339900
Hazardous Substances Data
66-97-7(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P8399
Product name
Psoralen
Purity
≥99% (HPLC)
Packaging
10mg
Price
$129
Updated
2024/03/01
Sigma-Aldrich
Product number
73633
Product name
Psoralen
Purity
analytical standard
Packaging
10mg
Price
$508
Updated
2022/05/15
TCI Chemical
Product number
P2077
Product name
Psoralen
Purity
>99.0%(GC)
Packaging
20mg
Price
$70
Updated
2024/03/01
TCI Chemical
Product number
P2077
Product name
Psoralen
Purity
>99.0%(GC)
Packaging
100mg
Price
$209
Updated
2024/03/01
Alfa Aesar
Product number
J60042
Product name
Psoralen, 97%
Packaging
100mg
Price
$241.65
Updated
2024/03/01
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Psoralen Chemical Properties,Usage,Production

Description

Psoralen is a kind of naturally occurring furocoumarin. It is naturally occurred in the seeds of Psoralea corylifolia as well as in the common fig, celery, parsley, West Indian Satinwood and all citrus fruits. It is capable of binding to DNA via single- and double-strand cross-linking upon photoactivation with UV radiation. It can intercalate with DNA, blocking its synthesis and cell division. For this reason, it is an important mutagen and can be used in related molecular biology studies. It also exhibits anti- proliferative, anti-allergenic and anti-histamine functions. It can also be used in PUVA treatment for skin diseases such as psoriasis, eczema and vitiligo. It is also effective tanning activator in sunscreens. Some of its derivatives, e.g. amino-psoralen, amotosalen HCl, can even inactivate pathogens in blood products.

References

https://en.wikipedia.org/wiki/Psoralen
https://pubchem.ncbi.nlm.nih.gov/compound/Psoralen#section=Top

Chemical Properties

Crystalline Solid

Uses

Use as photochemical probe in biological systems

Uses

Psoralens are phytoalexins; they are used by plants in a defensive response to attacks by fungi and insects. They have also shown photosensitizing and phototoxic effects in animals and humans and have been used in photochemotherapy for management of vitiligo, psoriasis, and mycosis fungoides. Used as photochemical probe in biological systems.

Uses

As photochemical probe in biological systems: P.-S. Song, C.-N. Ou, Ann. N.Y. Acad. Sci. 346, 355 (1980).

Definition

ChEBI: The simplest member of the class of psoralens that is 7H-furo[3,2-g]chromene having a keto group at position 7. It has been found in plants like Psoralea corylifolia and Ficus salicifolia.

Synthesis Reference(s)

Journal of the American Chemical Society, 106, p. 6735, 1984 DOI: 10.1021/ja00334a044
Synthetic Communications, 37, p. 63, 2007 DOI: 10.1080/00397910600978093

Biochem/physiol Actions

Psoralen belongs to the linear type furanocoumarins. It intercalates and induces interstrand cross-links in DNA. On UV exposure psoralen is excited leading to irreversible intercalation with DNA by covalent bond formation. This property of psoralen ultraviolet A light (PUVA) is exploited in treating skin diseases and cutaneous T-cell lymphoma. However, usage psoralen also leads to hepatotoxicity and cytotoxicity by the generation of psoralen photoproducts (POPs). It may be useful in treating osteoporosis

Psoralen Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Psoralen manufacturers

Chongqing Zhihe Biopharmaceutical Co., Ltd.
Product
Psoralen 66-97-7
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
≥98%
Supply Ability
20tons
Release date
2024-01-04
PNP Biotech Co. Ltd
Product
Psoralen 66-97-7
Price
US $0.00/kg
Min. Order
25kg
Purity
99%
Supply Ability
Inquiry
Release date
2022-09-29
Hebei Yibangte Import and Export Co. , Ltd.
Product
Psoralen 66-97-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000kg
Release date
2023-12-25

66-97-7, PsoralenRelated Search:


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  • 7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE
  • 7h-furo[3,2-g]benzopyran-7-one
  • FURO[3,2-G]BENZOPYRAN-7-ONE
  • FURO[3,2-G]COUMARIN
  • FICUSIN
  • 2-Propenoic acid, 3-(6-hydroxy-5-benzofuranyl)-, delta-lactone
  • 2-Propenoicacid,3-(6-hydroxy-5-benzofuranyl)-,δ-lactone
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